The Buffalo Bills have a record of 14-25-2 in the regular-season and playoffs versus the Chargers all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 10/2/1960 | 0-1 | vs | L 10-24 | .000 | 1 | 18 | 238 | 159 | ||||
| 2 | | Bills | 11/20/1960 | 1-0 | @ | W 32-3 | 1.000 | 5 | 14 | 248 | 185 | ||||
| 3 | | Bills | 9/30/1961 | 0-1 | vs | L 11-19 | .000 | 1 | 15 | 239 | 302 | ||||
| 4 | | Bills | 12/10/1961 | 0-1 | @ | L 10-28 | .000 | 1 | 18 | 279 | 237 | ||||
| 5 | | Bills | 10/13/1962 | 1-0 | vs | W 35-10 | 1.000 | 5 | 17 | 439 | 115 | ||||
| 6 | | Bills | 11/11/1962 | 1-0 | @ | W 40-20 | 1.000 | 5 | 20 | 335 | 370 | ||||
| 7 | | Bills | 9/8/1963 | 0-1 | @ | L 10-14 | .000 | 1 | 19 | 306 | 370 | ||||
| 8 | | Bills | 11/17/1963 | 0-1 | vs | L 13-23 | .000 | 1 | 22 | 358 | 355 | ||||
| 9 | | Bills | 9/26/1964 | 1-0 | vs | W 30-3 | 1.000 | 4 | 14 | 272 | 248 | ||||
| 10 | | Bills | 11/26/1964 | 1-0 | @ | W 27-24 | 1.000 | 3 | 18 | 273 | 334 | ||||
| 11 | | Bills | 12/26/1964 | 1-0 | vs | W 20-7 | 1.000 | 2 | 21 | 387 | 259 | ||||
| 12 | | Bills | 10/10/1965 | 0-1 | vs | L 3-34 | .000 | 0 | 8 | 150 | 458 | ||||
| 13 | | Bills | 11/25/1965 | 0-0-1 | @ | T 20-20 | .500 | 2 | 13 | 241 | 361 | ||||
| 14 | | Bills | 12/26/1965 | 1-0 | @ | W 23-0 | 1.000 | 2 | 23 | 260 | 223 | ||||
| 15 | | Bills | 9/4/1966 | 0-1 | @ | L 7-27 | .000 | 1 | 15 | 267 | 290 | ||||
| 16 | | Bills | 10/16/1966 | 0-0-1 | vs | T 17-17 | .500 | 2 | 22 | 320 | 219 | ||||
| 17 | | Bills | 10/1/1967 | 0-1 | vs | L 17-37 | .000 | 2 | 12 | 247 | 484 | ||||
| 18 | | Bills | 11/17/1968 | 0-1 | vs | L 6-21 | .000 | 0 | 7 | 151 | 282 | ||||
| 19 | | Bills | 12/14/1969 | 0-1 | @ | L 6-45 | .000 | 1 | 15 | 238 | 537 | ||||
| 20 | | Bills | 10/23/1971 | 0-1 | @ | L 3-20 | .000 | 0 | 11 | 189 | 446 | ||||
| 21 | | Bills | 9/23/1973 | 0-1 | @ | L 7-34 | .000 | 1 | 16 | 287 | 354 | ||||
| 22 | | Bills | 11/21/1976 | 0-1 | vs | L 13-34 | .000 | 1 | 14 | 219 | 382 | ||||
| 23 | | Bills | 9/16/1979 | 0-1 | @ | L 19-27 | .000 | 3 | 14 | 298 | 339 | ||||
| 24 | | Bills | 10/5/1980 | 1-0 | @ | W 26-24 | 1.000 | 3 | 14 | 202 | 300 | ||||
| 25 | | Bills | 1/3/1981 | 0-1 | @ | L 14-20 | .000 | 2 | 17 | 244 | 397 | ||||
| Average | .366 | 2.0 | 17.0 | 290.4 | 330.7 | ||||||||||
| Total | 14-25-2 | .366 | 83 | 699 | 11,908 | 13,557 | |||||||||
More Bills Stats
Team Leaders 
PASS
556
Allen
RUSH
163
Cook
REC
157
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
