The Buffalo Bills have had their highest point differential against a team in the regular season and playoffs on the road all-time against the Panthers, with a 52-point differential.
| OPP | DIFF | GP | W | L | T | TD | PTS | PPG | OPP PTS | OPP PPG | 1DWN | 3DWN% | 4DWN% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 52 | 4 | 3 | 1 | 0 | 10 | 93 | 23.3 | 41 | 10.3 | 60 | 40.0 | 0.0 | |
| 2 | 39 | 8 | 5 | 3 | 0 | 31 | 247 | 30.9 | 208 | 26.0 | 160 | |||
| 3 | 33 | 15 | 8 | 6 | 1 | 49 | 406 | 27.1 | 373 | 24.9 | 274 | 50.0 | ||
| 4 | 20 | 7 | 4 | 3 | 0 | 16 | 141 | 20.1 | 121 | 17.3 | 133 | |||
| 5 | 12 | 10 | 4 | 6 | 0 | 30 | 244 | 24.4 | 232 | 23.2 | 222 | |||
| 6 | 7 | 7 | 4 | 3 | 0 | 20 | 155 | 22.1 | 148 | 21.1 | 130 | 33.3 | ||
| 7 | 7 | 7 | 4 | 3 | 0 | 18 | 165 | 23.6 | 158 | 22.6 | 125 | |||
| 8 | 0 | 10 | 5 | 5 | 0 | 20 | 194 | 19.4 | 194 | 19.4 | 199 | 43.5 | 50.0 | |
| 9 | -15 | 7 | 4 | 3 | 0 | 19 | 165 | 23.6 | 180 | 25.7 | 153 | 100.0 | ||
| 10 | -15 | 31 | 15 | 16 | 0 | 75 | 663 | 21.4 | 678 | 21.9 | 571 | |||
| 11 | -18 | 7 | 2 | 5 | 0 | 13 | 121 | 17.3 | 139 | 19.9 | 128 | |||
| 12 | -19 | 13 | 5 | 8 | 0 | 32 | 254 | 19.5 | 273 | 21.0 | 237 | |||
| 13 | -20 | 9 | 3 | 6 | 0 | 19 | 188 | 20.9 | 208 | 23.1 | 162 | 34.6 | 60.0 | |
| 14 | -23 | 18 | 7 | 11 | 0 | 49 | 423 | 23.5 | 446 | 24.8 | 348 | |||
| 15 | -27 | 6 | 2 | 4 | 0 | 13 | 116 | 19.3 | 143 | 23.8 | 98 | 100.0 | ||
| 16 | -43 | 7 | 2 | 5 | 0 | 16 | 129 | 18.4 | 172 | 24.6 | 108 | |||
| 17 | -46 | 8 | 4 | 4 | 0 | 18 | 157 | 19.6 | 203 | 25.4 | 152 | |||
| 18 | -49 | 7 | 3 | 4 | 0 | 16 | 136 | 19.4 | 185 | 26.4 | 130 | |||
| 19 | -51 | 7 | 2 | 5 | 0 | 15 | 110 | 15.7 | 161 | 23.0 | 135 | 33.3 | ||
| 20 | -54 | 35 | 15 | 19 | 1 | 79 | 699 | 20.0 | 753 | 21.5 | 638 | |||
| 21 | -59 | 66 | 34 | 32 | 0 | 144 | 1,302 | 19.7 | 1,361 | 20.6 | 1,178 | |||
| 22 | -71 | 7 | 2 | 5 | 0 | 11 | 97 | 13.9 | 168 | 24.0 | 95 | |||
| 23 | -78 | 10 | 2 | 8 | 0 | 17 | 150 | 15.0 | 228 | 22.8 | 185 | |||
| 24 | -82 | 7 | 2 | 5 | 0 | 10 | 93 | 13.3 | 175 | 25.0 | 132 | 40.0 | ||
| 25 | -98 | 8 | 2 | 6 | 0 | 10 | 103 | 12.9 | 201 | 25.1 | 126 | 33.6 | 66.7 | |
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More Bills Stats
Team Leaders 
PASS
1,504
Allen
RUSH
627
Cook
REC
315
Kincaid
Team Rankings
PPG
32.8
1st
OPP PPG
28.5
28th
RUSH YDS/G
148.8
5th
PASS YDS/G
250.7
11th
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NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 2 | 1 | .583 | |
2 | 4 | 0 | .333 | |
2 | 4 | 0 | .333 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
4 | 2 | 0 | .667 | |
4 | 2 | 0 | .667 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
3 | 2 | 0 | .600 | |
2 | 4 | 0 | .333 | |
2 | 4 | 0 | .333 | |
1 | 5 | 0 | .167 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 3 | 0 | .500 | |
2 | 4 | 0 | .333 | |
2 | 4 | 0 | .333 |
Bears| AFC East | W | L | T | PCT |
|---|---|---|---|---|
5 | 1 | 0 | .833 | |
4 | 2 | 0 | .667 | |
2 | 4 | 0 | .333 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 2 | 0 | .667 | |
4 | 2 | 0 | .667 | |
4 | 2 | 0 | .667 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 2 | 0 | .667 | |
2 | 4 | 0 | .333 | |
2 | 4 | 0 | .333 | |
1 | 5 | 0 | .167 | |
| AFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
4 | 2 | 0 | .667 | |
3 | 3 | 0 | .500 | |
0 | 6 | 0 | .000 |
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