Thurman Thomas has scored the most total touchdowns for the Bills in a Week-1 game, with 4 touchdowns versus the Rams on September 6, 1992.
| NAME | TD | DATE | TM | OPP | RUSH TD | REC TD | RET TD | FGM | XPM | XP2 | SFTY | PTS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | T. Thomas | 4 | 9/6/1992 |  BUF | vs |  RAM | 3 | 1 | 0 | 0 | 0 | 0 | 24 | |
| 2 | | T. Henry | 3 | 9/8/2002 | BUF | vs |  NYJ | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 18 |
| 3 | | A. Reed | 3 | 9/5/1993 | BUF | vs |  NE | 0 | 3 | 0 | 0 | 0 | 0 | 18 | |
| 4 |  | J. Allen | 2 | 9/7/2025 | BUF | vs |  BAL | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 12 |
| 5 | | J. Allen | 2 | 9/8/2024 | BUF | vs |  ARI | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 12 |
| 6 | | S. Chandler | 2 | 9/11/2011 | BUF | @ |  KC | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 12 |
| 7 | | T. Henry | 2 | 9/7/2003 | BUF | vs | NE | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 12 |
| 8 | | A. Reed | 2 | 9/6/1998 | BUF | @ |  SD | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 12 |
| 9 | | T. Thomas | 2 | 9/1/1991 | BUF | vs |  MIA | 1 | 1 | 0 | 0 | 0 | 0 | 12 | |
| 10 | | R. Riddick | 2 | 9/13/1987 | BUF | vs |  NYJ | 1 | 1 | 0 | 0 | 0 | 0 | 12 | |
| 11 | | J. Cribbs | 2 | 9/6/1981 | BUF | vs | NYJ | 1 | 1 | 0 | 0 | 0 | 0 | 12 | |
| 12 | | J. Holland | 2 | 9/13/1976 | BUF | vs | MIA | 0 | 2 | 0 | 0 | 0 | 0 | 12 | |
| 13 |  | O.J. Simpson | 2 | 9/21/1975 | BUF | vs | NYJ | 2 | 0 | 0 | 0 | 0 | 0 | 12 | |
| 14 | | A. Rashad | 2 | 9/16/1974 | BUF | vs |  OAK | 0 | 2 | 0 | 0 | 0 | 0 | 12 | |
| 15 | | O.J. Simpson | 2 | 9/16/1973 | BUF | @ | NE | 2 | 0 | 0 | 0 | 0 | 0 | 12 | |
| 16 | | L. Watkins | 2 | 9/16/1973 | BUF | @ | NE | 2 | 0 | 0 | 0 | 0 | 0 | 12 | |
| 17 | | J.D. Hill | 2 | 9/17/1972 | BUF | vs | NYJ | 0 | 2 | 0 | 0 | 0 | 0 | 12 | |
| 18 | | M. Briscoe | 2 | 9/19/1971 | BUF | vs |  DAL | 0 | 2 | 0 | 0 | 0 | 0 | 12 | |
| 19 | | G. Bass | 2 | 9/13/1964 | BUF | vs | KC | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 12 |
| 20 |  | J. Cook III | 1 | 9/7/2025 | BUF | vs | BAL | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 21 |  | D. Kincaid | 1 | 9/7/2025 | BUF | vs | BAL | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
| 22 | | K. Coleman | 1 | 9/7/2025 | BUF | vs | BAL | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
| 23 | | M. Hollins | 1 | 9/8/2024 | BUF | vs | ARI | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
| 24 |  | K. Shakir | 1 | 9/8/2024 | BUF | vs | ARI | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
| 25 |  | S. Diggs | 1 | 9/11/2023 | BUF | @ |  NYJ | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
Results may be incomplete. StatMuse has complete game-level data for touchdowns going back to the 1950 season.
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30.6
3rd
OPP PPG
22.6
18th
RUSH YDS/G
154.4
2nd
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249.8
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 Eagles | 4 | 1 | 0 | .800 |
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