Between the 2010 and 2019 seasons, LeSean McCoy had the most rushing yards for the Bills, with 3,814 yards.
| NAME | RUSH YDS | GP | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. McCoy | 3,814 | 57 | 885 | 4.3 | 66.9 | 25 | 1,334 | 175 | 230 | 7.6 | 23.4 | 5 |
| 2 |  | F. Jackson | 3,713 | 66 | 854 | 4.3 | 56.3 | 25 | 1,762 | 217 | 302 | 8.1 | 26.7 | 5 |
| 3 | | C.J. Spiller | 3,321 | 70 | 668 | 5.0 | 47.4 | 12 | 1,195 | 158 | 202 | 7.6 | 17.1 | 6 |
| 4 |  | T. Taylor | 1,575 | 44 | 283 | 5.6 | 35.8 | 14 | 4 | 1 | 1 | 4.0 | 0.1 | 0 |
| 5 |  | J. Allen | 1,141 | 28 | 198 | 5.8 | 40.8 | 17 | 0 | 0 | 1 | 0.0 | 0 | |
| 6 | | M. Gillislee | 844 | 20 | 148 | 5.7 | 42.2 | 11 | 79 | 15 | 18 | 5.3 | 4.0 | 1 |
| 7 |  | D. Singletary | 775 | 12 | 151 | 5.1 | 64.6 | 2 | 194 | 29 | 41 | 6.7 | 16.2 | 2 |
| 8 |  | R. Fitzpatrick | 681 | 45 | 144 | 4.7 | 15.1 | 1 | 0 | 0 | 0 | 0.0 | 0 | |
| 9 |  | F. Gore | 599 | 16 | 166 | 3.6 | 37.4 | 2 | 100 | 13 | 16 | 7.7 | 6.3 | 0 |
| 10 | | K. Williams | 517 | 11 | 93 | 5.6 | 47.0 | 7 | 96 | 11 | 14 | 8.7 | 8.7 | 2 |
| 11 | | A. Dixon | 476 | 32 | 126 | 3.8 | 14.9 | 3 | 93 | 14 | 16 | 6.6 | 2.9 | 0 |
| 12 | | T. Choice | 389 | 30 | 105 | 3.7 | 13.0 | 2 | 70 | 15 | 32 | 4.7 | 2.3 | 0 |
| 13 | | C. Ivory | 385 | 13 | 115 | 3.3 | 29.6 | 1 | 205 | 13 | 21 | 15.8 | 15.8 | 0 |
| 14 | | EJ Manuel | 324 | 28 | 94 | 3.4 | 11.6 | 4 | 0 | 0 | 0 | 0.0 | 0 | |
| 15 | | M. Murphy | 291 | 12 | 59 | 4.9 | 24.3 | 0 | 33 | 13 | 21 | 2.5 | 2.8 | 0 |
| 16 | | M. Tolbert | 247 | 12 | 66 | 3.7 | 20.6 | 1 | 78 | 14 | 17 | 5.6 | 6.5 | 0 |
| 17 | | B. Smith | 203 | 30 | 34 | 6.0 | 6.8 | 2 | 392 | 37 | 64 | 10.6 | 13.1 | 3 |
| 18 |  | M. Lynch | 164 | 4 | 37 | 4.4 | 41.0 | 0 | 7 | 1 | 1 | 7.0 | 1.8 | 0 |
| 19 | | B. Brown | 126 | 7 | 36 | 3.5 | 18.0 | 0 | 176 | 16 | 25 | 11.0 | 25.1 | 0 |
| 20 | | I. McKenzie | 115 | 22 | 18 | 6.4 | 5.2 | 2 | 433 | 45 | 69 | 9.6 | 19.7 | 1 |
| 21 | | J. Williams | 94 | 11 | 27 | 3.5 | 8.5 | 1 | 0 | 1 | 2 | 0.0 | 0.0 | 0 |
| 22 | | T. Cadet | 93 | 6 | 22 | 4.2 | 15.5 | 0 | 93 | 13 | 16 | 7.2 | 15.5 | 0 |
| 23 | | K. Ford | 79 | 2 | 21 | 3.8 | 39.5 | 0 | 21 | 3 | 5 | 7.0 | 10.5 | 0 |
| 24 | | N. Peterman | 73 | 8 | 17 | 4.3 | 9.1 | 1 | 0 | 0 | 0 | 0.0 | 0 | |
| 25 | | J. White | 72 | 15 | 20 | 3.6 | 4.8 | 0 | -3 | 1 | 4 | -3.0 | -0.2 | 0 |
StatMuse has season-level data for rushing yards going back to the 1932 season.
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
