Between the 2010 and 2019 seasons, Preston Brown had the most tackles for the Bills, with 295 tackles.
| NAME | TKL | GP | AST | COMB | SCK | SCKY | INT | INT YDS | INT TD | FF | FR | FR TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | P. Brown | 295 | 64 | 217 | 512 | 1.0 | 5 | 3 | 46 | 1 | 2 | 4 | 0 |
| 2 | | K. Williams | 248 | 121 | 146 | 394 | 40.5 | 267 | 1 | 2 | 0 | 2 | 5 | 0 |
| 3 | | L. McKelvin | 234 | 79 | 40 | 274 | 0.0 | 0 | 11 | 50 | 0 | 3 | 8 | 0 |
| 4 | | J. Byrd | 227 | 59 | 84 | 311 | 3.0 | 21 | 13 | 291 | 2 | 11 | 5 | 0 |
| 5 | | C. Graham | 223 | 48 | 75 | 298 | 2.0 | 10 | 5 | 135 | 1 | 0 | 4 | 0 |
| 6 | | J. Hughes | 208 | 112 | 95 | 303 | 46.5 | 342.5 | 0 | 0 | 0 | 12 | 3 | 1 |
| 7 | | J. Poyer | 207 | 47 | 95 | 302 | 5.0 | 38 | 11 | 44 | 1 | 4 | 5 | 0 |
| 8 | | M. Dareus | 206 | 91 | 94 | 300 | 35.0 | 204.5 | 0 | 0 | 0 | 2 | 2 | 0 |
| 9 | | L. Alexander | 205 | 64 | 74 | 279 | 24.0 | 148.5 | 3 | 37 | 0 | 9 | 1 | 0 |
| 10 | | S. Gilmore | 198 | 68 | 28 | 226 | 0.0 | 0 | 14 | 252 | 0 | 4 | 1 | 0 |
| 11 | | A. Williams | 184 | 59 | 73 | 257 | 0.0 | 0 | 7 | 95 | 0 | 2 | 1 | 1 |
| 12 | | G. Wilson | 183 | 45 | 62 | 245 | 0.0 | 0 | 6 | 91 | 0 | 2 | 2 | 0 |
| 13 | | N. Bradham | 174 | 57 | 97 | 271 | 3.5 | 11 | 1 | 0 | 0 | 2 | 1 | 0 |
| 14 | | M. Hyde | 156 | 47 | 56 | 212 | 0.0 | 0 | 8 | 80 | 0 | 2 | 2 | 0 |
| 15 | | N. Barnett | 150 | 32 | 92 | 242 | 5.0 | 29 | 3 | 80 | 1 | 4 | 0 | 0 |
| 16 | | M. Milano | 149 | 44 | 79 | 228 | 2.5 | 20.5 | 4 | 56 | 0 | 2 | 5 | 1 |
| 17 | | T. Edmunds | 146 | 31 | 90 | 236 | 3.5 | 15.5 | 3 | 19 | 0 | 2 | 0 | 0 |
| 18 | | T. White | 145 | 47 | 36 | 181 | 1.0 | 9 | 12 | 180 | 0 | 3 | 2 | 1 |
| 19 | | D. Searcy | 144 | 62 | 65 | 209 | 4.0 | 30 | 5 | 102 | 1 | 3 | 3 | 1 |
| 20 | | N. Robey-Coleman | 139 | 64 | 29 | 168 | 5.0 | 25 | 3 | 63 | 2 | 2 | 4 | 1 |
| 21 | | B. Scott | 127 | 47 | 45 | 172 | 4.0 | 28 | 6 | 109 | 2 | 2 | 5 | 1 |
| 22 | | R. Darby | 121 | 29 | 16 | 137 | 0.0 | 0 | 2 | 48 | 0 | 0 | 0 | 0 |
| 23 | | M. Williams | 116 | 63 | 29 | 145 | 43.0 | 231 | 0 | 0 | 0 | 5 | 2 | 0 |
| 24 | | M. Lawson | 104 | 47 | 36 | 140 | 6.5 | 45.5 | 2 | 0 | 0 | 1 | 1 | 0 |
| 25 | | P. Posluszny | 103 | 14 | 48 | 151 | 2.0 | 16 | 0 | 0 | 0 | 0 | 0 | 0 |
StatMuse has season-level data for tackles going back to the 2001 season.
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REC
719
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Team Rankings
PPG
28.3
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OPP PPG
21.5
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RUSH YDS/G
159.6
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PASS YDS/G
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NFL 2025 Leaders
NFL 2025 Rankings
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NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
