The Buffalo Bills had their lowest point differential in a game against the Patriots on November 18, 2007, with a -46-point differential.
Interpreted as:
buffalo bills biggest loss in a regular-season game| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | -46 | 11/18/2007 | vs | L 10-56 | 1 | 14 | 229 | 510 | 40.0 | |||
| 2 | | Bills | -44 | 9/9/2018 | @ | L 3-47 | 0 | 10 | 153 | 369 | 13.3 | 0.0 | ||
| 3 | | Bills | -43 | 10/10/1971 | vs | L 0-43 | 0 | 4 | 49 | 401 | ||||
| 4 | | Bills | -42 | 10/7/2012 | @ | L 3-45 | 0 | 10 | 204 | 621 | 20.0 | |||
| 5 | | Bills | -42 | 9/15/1968 | vs | L 6-48 | 1 | 14 | 191 | 411 | ||||
| 6 | | Bills | -41 | 10/4/1987 | vs | L 6-47 | 1 | 14 | 163 | 463 | ||||
| 7 | | Bills | -39 | 9/15/1985 | @ | L 3-42 | 0 | 16 | 270 | 532 | ||||
| 8 | | Bills | -39 | 10/30/1977 | @ | L 17-56 | 2 | 17 | 336 | 559 | ||||
| 9 | | Bills | -39 | 12/14/1969 | @ | L 6-45 | 1 | 15 | 238 | 537 | ||||
| 10 | | Bills | -38 | 11/20/2005 | @ | L 10-48 | 1 | 12 | 202 | 478 | 23.1 | 50.0 | ||
| 11 | | Bills | -38 | 12/12/1976 | @ | L 20-58 | 2 | 21 | 355 | 396 | ||||
| 12 | | Bills | -38 | 11/12/1972 | @ | L 3-41 | 0 | 11 | 210 | 289 | ||||
| 13 | | Bills | -38 | 12/20/1970 | @ | L 7-45 | 1 | 10 | 197 | 325 | ||||
| 14 | | Bills | -37 | 11/12/2017 | vs | L 10-47 | 1 | 10 | 198 | 482 | 18.2 | 0.0 | ||
| 15 | | Bills | -37 | 11/13/2011 | @ | L 7-44 | 1 | 20 | 271 | 433 | 28.6 | 0.0 | ||
| 16 | | Bills | -35 | 12/2/2001 | @ | L 0-35 | 0 | 11 | 191 | 409 | 16.7 | 50.0 | ||
| 17 | | Bills | -34 | 11/7/1971 | @ | L 0-34 | 0 | 19 | 364 | 391 | ||||
| 18 | | Bills | -33 | 12/16/2012 | vs | L 17-50 | 2 | 21 | 333 | 466 | 38.5 | 0.0 | ||
| 19 | | Bills | -33 | 10/8/2006 | @ | L 7-40 | 1 | 10 | 145 | 351 | 18.2 | 0.0 | ||
| 20 | | Bills | -33 | 10/26/2003 | @ | L 5-38 | 0 | 15 | 266 | 375 | 27.3 | 0.0 | ||
| 21 | | Bills | -33 | 12/1/1985 | @ | L 7-40 | 1 | 21 | 347 | 365 | ||||
| 22 | | Bills | -32 | 11/4/2018 | vs | L 9-41 | 1 | 22 | 264 | 190 | 33.3 | 33.3 | ||
| 23 | | Bills | -32 | 10/21/2018 | @ | L 5-37 | 0 | 15 | 303 | 376 | 22.2 | 0.0 | ||
| 24 | | Bills | -32 | 10/6/1985 | @ | L 17-49 | 2 | 15 | 252 | 464 | ||||
| 25 | | Bills | -31 | 1/2/2011 | @ | L 7-38 | 1 | 6 | 162 | 388 | 33.3 | |||
BAL
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PASS
556
Allen
RUSH
163
Cook
REC
157
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
