The Arizona Cardinals have a 4-6 record versus the 49ers between September 25, 2020 and September 25, 2025.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cardinals | 12/26/2020 | 0-1 |  ARI | vs |  SF | L 12-20 | .000 | 1 | 20 | 350 | 398 | 25.0 | 66.7 |
| 2 | | Cardinals | 10/10/2021 | 1-0 | ARI | vs | SF | W 17-10 | 1.000 | 2 | 20 | 304 | 338 | 30.0 | |
| 3 | | Cardinals | 11/7/2021 | 1-0 | ARI | @ | SF | W 31-17 | 1.000 | 4 | 22 | 437 | 337 | 46.7 | 50.0 |
| 4 | | Cardinals | 11/21/2022 | 0-1 | ARI | vs | SF | L 10-38 | .000 | 1 | 19 | 314 | 387 | 50.0 | 0.0 |
| 5 | | Cardinals | 1/8/2023 | 0-1 | ARI | @ | SF | L 13-38 | .000 | 2 | 11 | 255 | 311 | 40.0 | 0.0 |
| 6 | | Cardinals | 10/1/2023 | 0-1 | ARI | @ | SF | L 16-35 | .000 | 2 | 23 | 362 | 395 | 53.3 | 66.7 |
| 7 | | Cardinals | 12/17/2023 | 0-1 | ARI | vs | SF | L 29-45 | .000 | 3 | 22 | 436 | 406 | 43.8 | 75.0 |
| 8 | | Cardinals | 10/6/2024 | 1-0 | ARI | @ | SF | W 24-23 | 1.000 | 2 | 19 | 358 | 384 | 30.0 | 100.0 |
| 9 | | Cardinals | 1/5/2025 | 1-0 | ARI | vs | SF | W 47-24 | 1.000 | 6 | 26 | 393 | 436 | 36.4 | 100.0 |
| 10 | | Cardinals | 9/21/2025 | 0-1 | ARI | @ | SF | L 15-16 | .000 | 1 | 16 | 260 | 355 | 33.3 | 100.0 |
| Average | .400 | 2.4 | 19.8 | 346.9 | 374.7 | 39.6 | 6.9 | ||||||||
| Total | 4-6 | .400 | 24 | 198 | 3,469 | 3,747 | 39.6 | 62.5 |
More Cardinals Stats
Team Rankings
PPG
20.7
19th
OPP PPG
17.0
5th
RUSH YDS/G
111.3
16th
PASS YDS/G
180.7
27th
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NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 3 | 0 | 0 | 1.000 |
 Commanders | 2 | 1 | 0 | .667 |
| NFC North | W | L | T | PCT |
 Packers | 2 | 1 | 0 | .667 |
 Vikings | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 0 | 0 | 1.000 |
 Panthers | 1 | 2 | 0 | .333 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 0 | 0 | 1.000 |
 Rams | 2 | 1 | 0 | .667 |
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