The Indianapolis Colts are 1-7 against the spread in their last 25 games against the AFC South in Week 1.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Colts | 9/8/2002 | 0-1 | @ | W 28-25 | -3.5 | -0.5 (N) | 43.5 | +9.5 (O) | 4 | 18 | 307 | 343 | 64.3 | |||||
| 2 | | Colts | 9/13/2009 | 0-1 | -290 | vs | +240 | W 14-12 | -7 | -5 (N) | 44.5 | -18.5 (U) | 2 | 21 | 365 | 228 | 57.1 | 0.0 | ||
| 3 | | Colts | 9/12/2010 | 0-1 | -125 | @ | +105 | L 24-34 | -1.5 | -11.5 (N) | 47.5 | +10.5 (O) | 3 | 25 | 463 | 355 | 33.3 | 100.0 | ||
| 4 | | Colts | 9/11/2011 | 0-1 | +330 | @ | -440 | L 7-34 | +8.5 | -18.5 (N) | 43.5 | -2.5 (U) | 1 | 15 | 236 | 384 | 11.1 | 0.0 | ||
| 5 | | Colts | 9/13/2020 | 0-1 | -370 | @ | +286 | L 20-27 | -7.5 | -14.5 (N) | 44.5 | +2.5 (O) | 2 | 27 | 445 | 241 | 33.3 | 33.3 | ||
| 6 | | Colts | 9/11/2022 | 0-1 | -329 | @ | +262 | T 20-20 | -7 | -7 (N) | 45.5 | -5.5 (U) | 2 | 33 | 517 | 299 | 40.0 | 0.0 | ||
| 7 | | Colts | 9/10/2023 | 0-1 | +165 | vs | -194 | L 21-31 | +3.5 | -6.5 (N) | 45.5 | +6.5 (O) | 3 | 18 | 280 | 342 | 16.7 | 20.0 | ||
| 8 | | Colts | 9/8/2024 | 1-0 | +136 | vs | -162 | L 27-29 | +3 | +1 (Y) | 48.5 | +7.5 (O) | 4 | 14 | 303 | 417 | 50.0 | 50.0 | ||
| Average | 1.6 | 2.6 | 21.4 | 364.5 | 326.1 | 39.8 | 3.8 | |||||||||||||
| Total | 1-7 | 21 | 171 | 2,916 | 2,609 | 39.8 | 26.7 |
IND
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Team Leaders 
PASS
3,101
Jones
RUSH
1,443
Taylor
REC
785
Pierce
Team Rankings
PPG
28.0
6th
OPP PPG
21.6
13th
RUSH YDS/G
128.9
5th
PASS YDS/G
241.1
10th
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NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
11 | 3 | 0 | .786 | |
11 | 4 | 0 | .733 | |
 Dolphins - e | 6 | 9 | 0 | .400 |
 Jets - e | 3 | 12 | 0 | .200 |
| AFC North | W | L | T | PCT |
9 | 6 | 0 | .600 | |
7 | 7 | 0 | .500 | |
 Bengals - e | 5 | 10 | 0 | .333 |
 Browns - e | 3 | 12 | 0 | .200 |
| AFC South | W | L | T | PCT |
11 | 4 | 0 | .733 | |
10 | 5 | 0 | .667 | |
8 | 6 | 0 | .571 | |
 Titans - e | 3 | 12 | 0 | .200 |
| AFC West | W | L | T | PCT |
 Broncos - x | 12 | 3 | 0 | .800 |
11 | 4 | 0 | .733 | |
 Chiefs - e | 6 | 9 | 0 | .400 |
 Raiders - e | 2 | 13 | 0 | .133 |
Patriots
Bills
Steelers
Ravens
Chargers| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 10 | 5 | 0 | .667 |
 Cowboys - e | 6 | 8 | 1 | .433 |
 Commanders - e | 4 | 11 | 0 | .267 |
 Giants - e | 2 | 13 | 0 | .133 |
| NFC North | W | L | T | PCT |
 Bears - x | 11 | 4 | 0 | .733 |
9 | 5 | 1 | .633 | |
8 | 7 | 0 | .533 | |
 Vikings - e | 7 | 8 | 0 | .467 |
| NFC South | W | L | T | PCT |
8 | 7 | 0 | .533 | |
7 | 8 | 0 | .467 | |
 Falcons - e | 6 | 9 | 0 | .400 |
 Saints - e | 5 | 10 | 0 | .333 |
| NFC West | W | L | T | PCT |
 Seahawks - x | 12 | 3 | 0 | .800 |
 Rams - x | 11 | 4 | 0 | .733 |
 49ers - x | 10 | 4 | 0 | .714 |
 Cardinals - e | 3 | 12 | 0 | .200 |
Packers
Lions
Panthers
Buccaneers
