The San Francisco 49ers have a 6-8 record against the spread as favorites against the NFC South at home since 2000.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/14/2004 | 0-1 |  SF | vs |  CAR | L 27-37 | -1 | -11 (N) | 41.5 | +22.5 (O) | 3 | 23 | 357 | 358 | 50.0 | 100.0 | ||
| 2 | | 49ers | 10/11/2009 | 0-1 | SF | -115 | vs |  ATL | -105 | L 10-45 | -2.5 | -37.5 (N) | 40 | +15 (O) | 1 | 13 | 279 | 477 | 28.6 | 50.0 |
| 3 | | 49ers | 11/21/2010 | 0-1 | SF | -190 | vs |  TB | +170 | L 0-21 | -3.5 | -24.5 (N) | 42 | -21 (U) | 0 | 11 | 189 | 299 | 25.0 | 0.0 |
| 4 | | 49ers | 10/9/2011 | 1-0 | SF | -150 | vs | TB | +130 | W 48-3 | -3 | +42 (Y) | 41.5 | +9.5 (O) | 6 | 28 | 418 | 272 | 28.6 | 100.0 |
| 5 | | 49ers | 11/10/2013 | 0-1 | SF | -260 | vs | CAR | +220 | L 9-10 | -6 | -7 (N) | 43 | -24 (U) | 0 | 10 | 151 | 250 | 15.4 | |
| 6 | | 49ers | 12/23/2013 | 0-1 | SF | -1000 | vs | ATL | +650 | W 34-24 | -14 | -4 (N) | 46 | +12 (O) | 4 | 20 | 379 | 402 | 44.4 | |
| 7 | | 49ers | 10/23/2016 | 0-1 | SF | -115 | vs | TB | -105 | L 17-34 | -1 | -18 (N) | 45 | +6 (O) | 2 | 20 | 273 | 513 | 40.0 | 100.0 |
| 8 | | 49ers | 10/27/2019 | 1-0 | SF | -209 | vs | CAR | +172 | W 51-13 | -4 | +34 (Y) | 40.5 | +23.5 (O) | 7 | 24 | 388 | 230 | 50.0 | |
| 9 | | 49ers | 12/15/2019 | 0-1 | SF | -460 | vs | ATL | +350 | L 22-29 | -10 | -17 (N) | 50 | +1 (O) | 2 | 20 | 313 | 290 | 33.3 | 100.0 |
| 10 | | 49ers | 12/19/2021 | 1-0 | SF | -408 | vs | ATL | +311 | W 31-13 | -9 | +9 (Y) | 47.5 | -3.5 (U) | 4 | 23 | 397 | 275 | 54.5 | |
| 11 | | 49ers | 11/27/2022 | 1-0 | SF | -426 | vs |  NO | +325 | W 13-0 | -8.5 | +4.5 (Y) | 43.5 | -30.5 (U) | 1 | 21 | 317 | 260 | 38.5 | 50.0 |
| 12 | | 49ers | 12/11/2022 | 1-0 | SF | -182 | vs | TB | +152 | W 35-7 | -3.5 | +24.5 (Y) | 38.5 | +3.5 (O) | 5 | 24 | 404 | 322 | 44.4 | 50.0 |
| 13 | | 49ers | 11/19/2023 | 0-1 | SF | -831 | vs | TB | +567 | W 27-14 | -13.5 | -0.5 (N) | 41.5 | -0.5 (U) | 3 | 22 | 420 | 287 | 40.0 | 0.0 |
| 14 | | 49ers | 10/19/2025 | 1-0 | SF | -106 | vs | ATL | -112 | W 20-10 | -1.5 | +8.5 (Y) | 46.5 | -16.5 (U) | 2 | 23 | 324 | 292 | 60.0 | |
| Average | 3.1 | 2.9 | 20.1 | 329.2 | 323.4 | 39.8 | 5.6 | |||||||||||||
| Total | 6-8 | 40 | 282 | 4,609 | 4,527 | 39.8 | 50.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
23.7
14th
OPP PPG
22.9
16th
RUSH YDS/G
94.8
28th
PASS YDS/G
267.0
3rd
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