James Cook III rushed for his most yards in a game against the Panthers last Sunday, with 216 yards.
Interpreted as:
james cook most rushing yards in a regular-season game in a fam| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 216 | 10/26/2025 |  BUF | @ |  CAR | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |
| 2 | | J. Cook III | 179 | 12/17/2023 | BUF | vs |  DAL | 25 | 7.2 | 1 | 42 | 2 | 3 | 21.0 | 1 |
| 3 | | J. Cook III | 132 | 9/14/2025 | BUF | @ |  NYJ | 21 | 6.3 | 2 | 3 | 1 | 1 | 3.0 | 0 |
| 4 | | J. Cook III | 123 | 9/17/2023 | BUF | vs |  LV | 17 | 7.2 | 0 | 36 | 4 | 4 | 9.0 | 0 |
| 5 | | J. Cook III | 117 | 9/28/2025 | BUF | vs |  NO | 22 | 5.3 | 1 | 18 | 3 | 4 | 6.0 | 0 |
| 6 | | J. Cook III | 114 | 11/2/2025 | BUF | vs |  KC | 27 | 4.2 | 0 | 11 | 1 | 1 | 11.0 | 0 |
| 7 | | J. Cook III | 111 | 10/27/2024 | BUF | @ |  SEA | 17 | 6.5 | 2 | 22 | 3 | 3 | 7.3 | 0 |
| 8 | | J. Cook III | 109 | 11/13/2023 | BUF | vs |  DEN | 12 | 9.1 | 0 | 11 | 2 | 2 | 5.5 | 0 |
| 9 | | J. Cook III | 108 | 9/18/2025 | BUF | vs |  MIA | 19 | 5.7 | 1 | 10 | 3 | 3 | 3.3 | 0 |
| 10 | | J. Cook III | 107 | 12/1/2024 | BUF | vs |  SF | 14 | 7.6 | 1 | 13 | 1 | 1 | 13.0 | 0 |
| 11 | | J. Cook III | 105 | 12/15/2024 | BUF | @ |  DET | 14 | 7.5 | 2 | 28 | 1 | 1 | 28.0 | 0 |
| 12 | | J. Cook III | 100 | 12/22/2024 | BUF | vs |  NE | 11 | 9.1 | 1 | 26 | 3 | 3 | 8.7 | 1 |
| 13 | | J. Cook III | 99 | 12/24/2022 | BUF | @ |  CHI | 11 | 9.0 | 1 | 9 | 1 | 2 | 9.0 | 0 |
| 14 | | J. Cook III | 98 | 9/24/2023 | BUF | @ |  WAS | 15 | 6.5 | 0 | 14 | 2 | 3 | 7.0 | 0 |
| 15 | | J. Cook III | 87 | 10/13/2025 | BUF | @ |  ATL | 17 | 5.1 | 0 | 0 | 0 | 0 | 0 | |
| 16 | | J. Cook III | 86 | 11/20/2022 | BUF | vs |  CLE | 11 | 7.8 | 0 | 0 | 0 | 1 | 0 | |
| 17 | | J. Cook III | 82 | 10/6/2024 | BUF | @ |  HOU | 20 | 4.1 | 1 | 17 | 2 | 3 | 8.5 | 0 |
| 18 | | J. Cook III | 80 | 11/10/2024 | BUF | @ |  IND | 19 | 4.2 | 1 | 5 | 1 | 3 | 5.0 | 0 |
| 19 | | J. Cook III | 78 | 9/12/2024 | BUF | @ | MIA | 11 | 7.1 | 2 | 17 | 1 | 1 | 17.0 | 1 |
| 20 | | J. Cook III | 73 | 11/19/2023 | BUF | vs |  NYJ | 17 | 4.3 | 0 | 29 | 3 | 4 | 9.7 | 1 |
| 21 | | J. Cook III | 71 | 9/8/2024 | BUF | vs |  ARI | 19 | 3.7 | 0 | 32 | 3 | 3 | 10.7 | 0 |
| 22 | | J. Cook III | 71 | 10/15/2023 | BUF | vs |  NYG | 14 | 5.1 | 0 | 0 | 0 | 0 | 0 | |
| 23 | | J. Cook III | 70 | 12/23/2023 | BUF | @ |  LAC | 20 | 3.5 | 0 | 0 | 0 | 0 | 0 | |
| 24 | | J. Cook III | 67 | 10/26/2023 | BUF | vs |  TB | 14 | 4.8 | 0 | 6 | 1 | 1 | 6.0 | 0 |
| 25 | | J. Cook III | 64 | 12/1/2022 | BUF | @ | NE | 14 | 4.6 | 0 | 41 | 6 | 6 | 6.8 | 0 |
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More Bills Stats
Team Rankings
PPG
29.4
4th
OPP PPG
20.9
9th
RUSH YDS/G
161.5
1st
PASS YDS/G
235.9
14th
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