| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | San Francisco 49ers | -123 | @ |  Seattle Seahawks | +104 | WK 1 | Sun, Sep 7, 2025 | 4:05 PM | -1.5 | 45.5 |
| 2 | | San Francisco 49ers | -338 | @ |  New Orleans Saints | +265 | WK 2 | Sun, Sep 14, 2025 | 1:00 PM | -7.0 | 45.0 |
| 3 | | San Francisco 49ers | -186 | vs |  Arizona Cardinals | +150 | WK 3 | Sun, Sep 21, 2025 | 4:25 PM | -3.5 | 47.5 |
| 4 | | San Francisco 49ers | +104 | @ |  Los Angeles Rams | -127 | WK 5 | Thu, Oct 2, 2025 | 8:15 PM | +1.5 | 47.5 |
| 5 | | San Francisco 49ers | -125 | vs | Los Angeles Rams | +102 | WK 10 | Sun, Nov 9, 2025 | 4:25 PM | -1.5 | 46.5 |
| 6 | | San Francisco 49ers | -124 | @ | Arizona Cardinals | +101 | WK 11 | Sun, Nov 16, 2025 | 4:05 PM | -1.5 | 47.5 |
Betting lines shown represent consensus, closing odds.
More 49ers Stats
Team Rankings
PPG
22.9
13th
OPP PPG
25.6
29th
RUSH YDS/G
127.2
12th
PASS YDS/G
260.2
4th
49ers 
JAX 
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NFL 2024 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 14 | 3 | 0 | .824 |
 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
 Lions | 15 | 2 | 0 | .882 |
 Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
 Buccaneers | 10 | 7 | 0 | .588 |
 Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
| Rams | 10 | 7 | 0 | .588 |
| Seahawks | 10 | 7 | 0 | .588 |
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