Ron McDole has made the most career interceptions by a defensive lineman, with 12 interceptions.

most interceptions in a career by a defensive end
Interpreted as:
most defensive interceptions in a career by a defensive end
McDoleForesterPeppersDentTaylorDodrillDuncanAllenDolemanFaisonNgataWilliamsBrownWistromBrackensRiceWilkinsonJohnsonHandSzymanskiGeorgePierre-Paul121098777666555555555554
NAMEGPINTTKLASTCOMBSCKSCKYINT YDSINT TDFFFRFR TD
Ron McDoleRon McDole240121151141
Bill ForesterBill Forester481088030
Julius PeppersJulius Peppers2189488128616134.5813.5192243172
Richard DentRichard Dent2038137.5891131
Jason TaylorJason Taylor1857336152488120.5110334265
Dale DodrillDale Dodrill67757091
Jim DuncanJim Duncan43782040
Jared AllenJared Allen1876503145648136.0851.555131191
Chris DolemanChris Doleman2006147.0571211
Earl FaisonEarl Faison736136200
Haloti NgataHaloti Ngata180532818851632.5231.5840751
Kevin WilliamsKevin Williams203537015852863.0401.58229132
Alex BrownAlex Brown14353397541445.5335.527015120
Grant WistromGrant Wistrom13252385229053.01292680
Tony BrackensTony Brackens107582119355.05417130
Simeon RiceSimeon Rice174521438252122.04802580
Dan WilkinsonDan Wilkinson1955973212954.5991440
Charlie JohnsonCharlie Johnson11756.011092
Larry HandLarry Hand1645110380
Dick SzymanskiDick Szymanski12524100
Bill GeorgeBill George48523080
Jason Pierre-PaulJason Pierre-Paul153441815457289.0609.567220101
Michael JohnsonMichael Johnson155426813039844.5288.5321840
Jonathan BabineauxJonathan Babineaux185429110339427.0178.53010102
Darnell DockettDarnell Dockett158435111346440.52713607142
StatMuse has season-level data for interceptions going back to the 1940 season.

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