Matthew Stafford has the most passing yards in a game against the Cowboys, with 488 yards on October 27, 2013.

most passing yards in a game vs cowboys
Interpreted as:
most passing yards by a player in a regular-season game vs cowboys
10/27/2013Stafford11/18/1962Wade11/15/1998Plummer9/8/2013Manning11/24/2016Cousins12/23/2012Brees11/23/2017Rivers11/10/1991Moon10/6/1985Simms10/6/2013Manning12/6/2004Hasselbeck11/28/1965Jurgensen11/13/2016Roethlisberger10/25/1981Woodley9/29/2013Rivers12/11/2011Manning11/10/2013Brees10/14/2007Brady11/11/1984Lomax12/10/2006Brees9/20/1992Chandler9/12/1999Johnson10/20/1985Jaworski488466465450449446434432432414414411408408401400392388388384383382380
NAMEDATETMOPPYDSCMPATTPCTAVGTDTD%INTINT%SCKSCKYRATE
Matthew StaffordMatthew Stafford10/27/2013DETDETvs. DAL
vs.
488334868.810.212.124.21891.3
Billy WadeBilly Wade11/18/1962CHICHI@ DLC
@
466284660.910.124.324.391.4
Jake PlummerJake Plummer11/15/1998ARIARIvs. DAL
vs.
465315655.48.335.411.831793.2
Eli ManningEli Manning9/8/2013NYGNYG@ DAL
@
450274264.310.749.537.1322102.3
Kirk CousinsKirk Cousins11/24/2016WASWAS@ DAL
@
449415377.48.535.700.000120.7
Drew BreesDrew Brees12/23/2012NONO@ DAL
@
446375369.88.435.700.000114.2
Philip RiversPhilip Rivers11/23/2017LACLAC@ DAL
@
434273381.813.239.100.000149.1
Warren MoonWarren Moon11/10/1991HOUHOUvs. DAL
vs.
432415673.27.700.000.02795.2
Phil SimmsPhil Simms10/6/1985NYGNYGvs. DAL
vs.
432183650.012.038.325.642998.4
Peyton ManningPeyton Manning10/6/2013DENDEN@ DAL
@
414334278.69.949.512.400129.6
Matt HasselbeckMatt Hasselbeck12/6/2004SEASEAvs. DAL
vs.
414284070.010.437.500.0216128.5
Sonny JurgensenSonny Jurgensen11/28/1965WASWASvs. DAL
vs.
411264360.59.637.024.796.2
Ben RoethlisbergerBen Roethlisberger11/13/2016PITPITvs. DAL
vs.
408374680.48.936.500.018125.4
David WoodleyDavid Woodley10/25/1981MIAMIA@ DAL
@
408213756.811.038.1513.532782.8
Philip RiversPhilip Rivers9/29/2013SDSDvs. DAL
vs.
401354283.39.537.112.417120.3
Eli ManningEli Manning12/11/2011NYGNYG@ DAL
@
400274757.48.524.312.10090.7
Drew BreesDrew Brees11/10/2013NONOvs. DAL
vs.
392344182.99.649.800.019139.0
Tom BradyTom Brady10/14/2007NENE@ DAL
@
388314667.48.4510.900.0315129.6
Neil LomaxNeil Lomax11/11/1984STLSTLvs. DAL
vs.
388275251.97.523.823.853173.2
Drew BreesDrew Brees12/10/2006NONO@ DAL
@
384263868.410.1513.200.017140.8
Chris ChandlerChris Chandler9/20/1992PHXPHX@ DAL
@
383284365.18.912.300.0212101.2
Brad JohnsonBrad Johnson9/12/1999WASWASvs. DAL
vs.
382203360.611.626.100.0213121.0
Ron JaworskiRon Jaworski10/20/1985PHIPHIvs. DAL
vs.
380223562.910.912.900.0433109.2
Ed BrownEd Brown10/27/1963PITPITvs. DAL
vs.
377153148.412.2412.939.793.1
Deshaun WatsonDeshaun Watson10/7/2018HOUHOUvs. DAL
vs.
375334475.08.512.312.31198.2
Results may be incomplete. StatMuse has complete game-level data for passing yards going back to the 1950 season.

See Trending NFL Searches