The Buffalo Bills had their most points in a game in 2021 against the Jets on November 14, 2021, with 45 points.
Interpreted as:
most points scored in a regular-season game by the bills in 2021| TEAM | PTS | DATE | TM | OPP | RESULT | PASS TD | RUSH TD | RET TD | TD | FGM | XPM | XP2 | SFTY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 45 | 11/14/2021 | @ | W 45-17 | 2 | 4 | 0 | 6 | 1 | 6 | 0 | 0 | ||
| 2 | | Bills | 43 | 9/26/2021 | vs | W 43-21 | 4 | 1 | 0 | 5 | 3 | 4 | 0 | 0 | ||
| 3 | | Bills | 40 | 10/3/2021 | vs | W 40-0 | 2 | 2 | 0 | 4 | 4 | 4 | 0 | 0 | ||
| 4 | | Bills | 38 | 10/10/2021 | @ | W 38-20 | 3 | 1 | 1 | 5 | 1 | 5 | 0 | 0 | ||
| 5 | | Bills | 35 | 9/19/2021 | @ | W 35-0 | 2 | 3 | 0 | 5 | 0 | 5 | 0 | 0 | ||
| 6 | | Bills | 33 | 12/26/2021 | @ | W 33-21 | 3 | 1 | 0 | 4 | 2 | 3 | 0 | 0 | ||
| 7 | | Bills | 31 | 12/19/2021 | vs | W 31-14 | 3 | 1 | 0 | 4 | 1 | 4 | 0 | 0 | ||
| 8 | | Bills | 31 | 11/25/2021 | @ | W 31-6 | 4 | 0 | 0 | 4 | 1 | 4 | 0 | 0 | ||
| 9 | | Bills | 31 | 10/18/2021 | @ | L 31-34 | 3 | 0 | 0 | 3 | 3 | 2 | 1 | 0 | ||
| 10 | | Bills | 29 | 1/2/2022 | vs | W 29-15 | 0 | 4 | 0 | 4 | 0 | 3 | 1 | 0 | ||
| 11 | | Bills | 27 | 1/9/2022 | vs | W 27-10 | 2 | 1 | 0 | 3 | 2 | 3 | 0 | 0 | ||
| 12 | | Bills | 27 | 12/12/2021 | @ | L 27-33 | 2 | 1 | 0 | 3 | 2 | 3 | 0 | 0 | ||
| 13 | | Bills | 26 | 10/31/2021 | vs | W 26-11 | 2 | 1 | 0 | 3 | 2 | 2 | 0 | 0 | ||
| 14 | | Bills | 16 | 9/12/2021 | vs | L 16-23 | 1 | 0 | 0 | 1 | 3 | 1 | 0 | 0 | ||
| 15 | | Bills | 15 | 11/21/2021 | vs | L 15-41 | 2 | 0 | 0 | 2 | 0 | 1 | 1 | 0 | ||
| 16 | | Bills | 10 | 12/6/2021 | vs | L 10-14 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | ||
| 17 | | Bills | 6 | 11/7/2021 | @ | L 6-9 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
NYJ
WASMore Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
