Between the 2013 and 2017 seasons, LeSean McCoy rushed for the most yards by a running back, with 6,226 yards.
| NAME | RUSH YDS | GP | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. McCoy | 6,226 | 75 | 1,350 | 4.6 | 83.0 | 36 | 1,790 | 221 | 285 | 8.1 | 23.9 | 7 |
| 2 |  | D. Murray | 5,614 | 76 | 1,279 | 4.4 | 73.9 | 43 | 1,731 | 246 | 299 | 7.0 | 22.8 | 6 |
| 3 |  | L. Bell | 5,336 | 62 | 1,229 | 4.3 | 86.1 | 35 | 2,660 | 312 | 397 | 8.5 | 42.9 | 7 |
| 4 |  | F. Gore | 5,187 | 80 | 1,315 | 3.9 | 64.8 | 26 | 1,041 | 128 | 188 | 8.1 | 13.0 | 7 |
| 5 |  | L. Miller | 4,641 | 78 | 1,093 | 4.2 | 59.5 | 26 | 1,357 | 178 | 228 | 7.6 | 17.4 | 7 |
| 6 |  | M. Forte | 4,469 | 71 | 1,094 | 4.1 | 62.9 | 28 | 2,347 | 287 | 370 | 8.2 | 33.1 | 12 |
| 7 |  | M. Ingram | 4,286 | 68 | 905 | 4.7 | 63.0 | 34 | 1,353 | 190 | 236 | 7.1 | 19.9 | 4 |
| 8 |  | L. Blount | 3,949 | 76 | 915 | 4.3 | 52.0 | 38 | 223 | 33 | 40 | 6.8 | 2.9 | 2 |
| 9 |  | A. Morris | 3,890 | 76 | 927 | 4.2 | 51.2 | 19 | 344 | 46 | 66 | 7.5 | 4.5 | 0 |
| 10 |  | M. Lynch | 3,871 | 54 | 899 | 4.3 | 71.7 | 35 | 914 | 106 | 144 | 8.6 | 16.9 | 6 |
| 11 | | E. Lacy | 3,614 | 60 | 857 | 4.2 | 60.2 | 23 | 947 | 107 | 140 | 8.9 | 15.8 | 6 |
| 12 | | C. Ivory | 3,545 | 71 | 856 | 4.1 | 49.9 | 20 | 711 | 91 | 127 | 7.8 | 10.0 | 3 |
| 13 | | J. Stewart | 3,482 | 60 | 881 | 4.0 | 58.0 | 24 | 436 | 64 | 95 | 6.8 | 7.3 | 3 |
| 14 |  | A. Peterson | 3,427 | 44 | 820 | 4.2 | 77.9 | 23 | 489 | 75 | 104 | 6.5 | 11.1 | 1 |
| 15 |  | T. Gurley | 3,296 | 44 | 786 | 4.2 | 74.9 | 29 | 1,303 | 128 | 171 | 10.2 | 29.6 | 6 |
| 16 |  | D. Freeman | 3,248 | 61 | 753 | 4.3 | 53.2 | 30 | 1,582 | 193 | 246 | 8.2 | 25.9 | 7 |
| 17 |  | D. Martin | 3,179 | 52 | 831 | 3.8 | 61.1 | 15 | 619 | 81 | 122 | 7.6 | 11.9 | 1 |
| 18 |  | L. Murray | 3,120 | 61 | 759 | 4.1 | 51.1 | 28 | 742 | 106 | 136 | 7.0 | 12.2 | 0 |
| 19 | | I. Crowell | 3,118 | 64 | 737 | 4.2 | 48.7 | 21 | 770 | 96 | 131 | 8.0 | 12.0 | 1 |
| 20 | | C.J. Anderson | 3,051 | 58 | 693 | 4.4 | 52.6 | 20 | 859 | 103 | 145 | 8.3 | 14.8 | 4 |
| 21 | | J. Charles | 3,020 | 52 | 617 | 4.9 | 58.1 | 27 | 1,304 | 156 | 224 | 8.4 | 25.1 | 13 |
| 22 | | G. Bernard | 2,900 | 71 | 688 | 4.2 | 40.8 | 16 | 2,060 | 230 | 306 | 9.0 | 29.0 | 8 |
| 23 | | J. Hill | 2,873 | 54 | 704 | 4.1 | 53.2 | 29 | 484 | 67 | 82 | 7.2 | 9.0 | 1 |
| 24 | | R. Jennings | 2,828 | 55 | 706 | 4.0 | 51.4 | 16 | 1,015 | 130 | 170 | 7.8 | 18.5 | 2 |
| 25 | | R. Mathews | 2,785 | 48 | 620 | 4.5 | 58.0 | 23 | 519 | 68 | 85 | 7.6 | 10.8 | 3 |
StatMuse has season-level data for rushing yards going back to the 1932 season.
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |