Mario Williams has the most sacks for the Bills in a game, with 4.5 sacks versus the Panthers on September 15, 2013.
Interpreted as:
most defensive sacks in a single regular-season game by a buffalo bills player| NAME | SCK | DATE | TM | OPP | TKL | AST | COMB | SCKY | INT | INT YDS | INT TD | FF | FR | FR TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | M. Williams | 4.5 | 9/15/2013 | vs | 5 | 1 | 6 | 24.5 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 2 |  | B. Smith | 4.0 | 9/18/1994 | @ | 0 | 0 | 0 | 0 | ||||||||
| 3 | | B. Smith | 4.0 | 12/9/1990 | @ | 0 | 0 | 0 | 0 | ||||||||
| 4 | | C. Bennett | 4.0 | 12/27/1987 | @ | 0 | 0 | 0 | 0 | ||||||||
| 5 | | M. Williams | 3.5 | 11/13/2014 | @ | 4 | 1 | 5 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 6 | | G. Rousseau | 3.0 | 9/8/2024 | vs | 6 | 0 | 6 | 11 | 0 | 0 | 0 | 1 | 0 | 0 | ||
| 7 | | J. Phillips | 3.0 | 10/6/2019 | @ | 3 | 0 | 3 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 8 | | L. Alexander | 3.0 | 10/9/2016 | @ | 7 | 0 | 7 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 9 | | M. Dareus | 3.0 | 11/9/2014 | vs | 4 | 3 | 7 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 10 | | M. Dareus | 3.0 | 10/5/2014 | @ | 5 | 0 | 5 | 18 | 0 | 0 | 0 | 1 | 0 | 0 | ||
| 11 | | M. Williams | 3.0 | 11/25/2012 | @ | 3 | 0 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 12 | | C. Kelsay | 3.0 | 12/24/2011 | vs | 7 | 3 | 10 | 27 | 0 | 0 | 0 | 1 | 0 | 0 | ||
| 13 | | A. Schobel | 3.0 | 12/27/2009 | @ | 4 | 0 | 4 | 16 | 0 | 0 | 0 | 2 | 0 | 0 | ||
| 14 | | A. Schobel | 3.0 | 12/10/2006 | @ | 6 | 3 | 9 | 31 | 0 | 0 | 0 | 1 | 0 | 0 | ||
| 15 | | R. Denney | 3.0 | 9/17/2006 | @ | 4 | 0 | 4 | 33 | 0 | 0 | 0 | 1 | 0 | 0 | ||
| 16 | | L. Milloy | 3.0 | 11/21/2004 | vs | 6 | 0 | 6 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 17 | | A. Schobel | 3.0 | 11/30/2003 | @ | 5 | 0 | 5 | 18 | 0 | 0 | 0 | 0 | 1 | 0 | ||
| 18 | | P. Williams | 3.0 | 12/6/1998 | @ | 0 | 0 | 0 | 0 | ||||||||
| 19 | | B. Paup | 3.0 | 9/7/1997 | @ | 0 | 0 | 0 | 0 | ||||||||
| 20 | | B. Smith | 3.0 | 9/8/1996 | vs | 0 | 0 | 0 | 0 | ||||||||
| 21 | | B. Smith | 3.0 | 12/3/1995 | @ | 0 | 0 | 0 | 0 | ||||||||
| 22 | | B. Paup | 3.0 | 11/5/1995 | @ | 0 | 0 | 0 | 0 | ||||||||
| 23 | | B. Paup | 3.0 | 9/17/1995 | vs | 0 | 0 | 0 | 0 | ||||||||
| 24 | | B. Smith | 3.0 | 9/20/1992 | vs | 0 | 0 | 0 | 0 | ||||||||
| 25 | | B. Smith | 3.0 | 10/22/1989 | vs | 0 | 0 | 0 | 0 | ||||||||
CAR
HOU
LA
NYJStatMuse has game-level data for sacks going back to the 1982 season.
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,606
Cook
REC
719
Shakir
Team Rankings
PPG
27.9
6th
OPP PPG
22.3
12th
RUSH YDS/G
156.4
2nd
PASS YDS/G
232.6
18th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 13 | 3 | 0 | .813 |
 Bills - w | 11 | 5 | 0 | .688 |
 Dolphins - e | 7 | 9 | 0 | .438 |
 Jets - e | 3 | 13 | 0 | .188 |
| AFC North | W | L | T | PCT |
9 | 7 | 0 | .563 | |
8 | 8 | 0 | .500 | |
 Bengals - e | 6 | 10 | 0 | .375 |
 Browns - e | 4 | 12 | 0 | .250 |
| AFC South | W | L | T | PCT |
 Jaguars - x | 12 | 4 | 0 | .750 |
 Texans - x | 11 | 5 | 0 | .688 |
 Colts - e | 8 | 8 | 0 | .500 |
 Titans - e | 3 | 13 | 0 | .188 |
| AFC West | W | L | T | PCT |
 Broncos - y | 13 | 3 | 0 | .813 |
 Chargers - w | 11 | 5 | 0 | .688 |
 Chiefs - e | 6 | 10 | 0 | .375 |
 Raiders - e | 2 | 14 | 0 | .125 |
Steelers
Ravens| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 5 | 0 | .688 |
 Cowboys - e | 7 | 8 | 1 | .469 |
 Commanders - e | 4 | 12 | 0 | .250 |
 Giants - e | 3 | 13 | 0 | .188 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 5 | 0 | .688 |
 Packers - w | 9 | 6 | 1 | .594 |
 Vikings - e | 8 | 8 | 0 | .500 |
 Lions - e | 8 | 8 | 0 | .500 |
| NFC South | W | L | T | PCT |
8 | 8 | 0 | .500 | |
7 | 9 | 0 | .438 | |
 Falcons - e | 7 | 9 | 0 | .438 |
 Saints - e | 6 | 10 | 0 | .375 |
| NFC West | W | L | T | PCT |
 Seahawks - x | 13 | 3 | 0 | .813 |
 49ers - x | 12 | 4 | 0 | .750 |
 Rams - w | 11 | 5 | 0 | .688 |
 Cardinals - e | 3 | 13 | 0 | .188 |
Buccaneers
