Derrick Thomas has the most sacks in a game, with 7 sacks versus the Seahawks on November 11, 1990.

most sacks in an nfl game by a player
Interpreted as:
most defensive sacks in an NFL regular-season game by a player
11/11/1990Thomas11/12/2017Clayborn9/30/2007Umenyiora9/6/1998Thomas11/13/1983Dean11/19/2012Smith9/4/1983Gay12/13/2020Reddick12/13/2015Mack9/20/2009Odom12/22/2002Holliday10/12/1997Smith9/18/1988Jeter11/16/1986O'Neal11/10/1985Jeffcoat9/16/1984Holloway10/2/1983Long9/19/2013Houston9/15/2013Williams9/30/2012Wake10/5/2009Allen10/18/1998Douglas10/13/1996Brown7.06.06.06.06.05.55.55.05.05.05.05.05.05.05.05.05.04.54.54.54.54.54.5
StatMuse has game-level data for sacks going back to the 1982 season.

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