Alex Highsmith and Khalil Mack were tied for the most sacks in a Week-1 game in 2022, with 3 sacks on September 11, 2022.

Interpreted as:

most defensive sacks by a player week 1 2022

	NAME	SCK	DATE	TM		OPP	TKL	AST	COMB	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Alex Highsmith A. Highsmith	3.0	9/11/2022	PIT	@	CIN	6	3	9	23	0	0	0	1	0	0
2	Khalil Mack K. Mack	3.0	9/11/2022	LAC	vs	LV	5	1	6	17	0	0	0	1	0	0
3	Bradley Chubb B. Chubb	2.0	9/12/2022	DEN	@	SEA	4	1	5	18	0	0	0	1	0	0
4	Myles Garrett M. Garrett	2.0	9/11/2022	CLE	@	CAR	4	0	4	11	0	0	0	1	0	0
5	Jerry Hughes J. Hughes	2.0	9/11/2022	HOU	vs	IND	3	0	3	12	1	14	0	1	0	0
6	Kwity Paye K. Paye	2.0	9/11/2022	IND	@	HOU	6	1	7	11	0	0	0	0	0	0
7	Jeffery Simmons J. Simmons	2.0	9/11/2022	TEN	vs	NYG	4	2	6	19	0	0	0	1	0	0
8	Rashad Weaver R. Weaver	2.0	9/11/2022	TEN	vs	NYG	3	1	4	7	0	0	0	0	0	0
9	Devin White D. White	2.0	9/11/2022	TB	@	DAL	7	1	8	17	0	0	0	0	0	0
10	Micah Parsons M. Parsons	2.0	9/11/2022	DAL	vs	TB	4	1	5	17	0	0	0	0	0	0
11	Von Miller V. Miller	2.0	9/8/2022	BUF	@	LAR	4	0	4	17	0	0	0	0	0	0
12	Dominique Robinson D. Robinson	1.5	9/11/2022	CHI	vs	SF	5	2	7	7.5	0	0	0	0	0	0
13	Grady Jarrett G. Jarrett	1.5	9/11/2022	ATL	vs	NO	3	3	6	14	0	0	0	0	0	0
14	Joey Bosa J. Bosa	1.5	9/11/2022	LAC	vs	LV	2	1	3	12.5	0	0	0	1	0	0
15	Jordan Phillips J. Phillips	1.5	9/8/2022	BUF	@	LAR	2	2	4	14.5	0	0	0	0	0	0
16	A.J. Epenesa	1.5	9/8/2022	BUF	@	LAR	1	1	2	10.5	0	0	0	0	0	0
17	Uchenna Nwosu U. Nwosu	1.0	9/12/2022	SEA	vs	DEN	3	4	7	2	0	0	0	1	0	0
18	Cody Barton C. Barton	1.0	9/12/2022	SEA	vs	DEN	8	2	10	8	0	0	0	0	0	0
19	Emmanuel Ogbah E. Ogbah	1.0	9/11/2022	MIA	vs	NE	3	1	4	7	0	0	0	0	0	0
20	Matthew Judon M. Judon	1.0	9/11/2022	NE	@	MIA	2	3	5	9	0	0	0	0	0	0
21	Deatrich Wise Jr. D. Wise Jr.	1.0	9/11/2022	NE	@	MIA	2	1	3	7	0	0	0	1	0	0
22	Ja'Whaun Bentley J. Bentley	1.0	9/11/2022	NE	@	MIA	4	3	7	12	0	0	0	0	0	0
23	Brandon Jones B. Jones	1.0	9/11/2022	MIA	vs	NE	6	5	11	13	0	0	0	1	0	0
24	Samson Ebukam S. Ebukam	1.0	9/11/2022	SF	@	CHI	2	0	2	10	0	0	0	0	0	0
25	Nick Bosa N. Bosa	1.0	9/11/2022	SF	@	CHI	4	1	5	6	0	0	0	0	0	0

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Alex Highsmith and Khalil Mack were tied for the most sacks in a Week-1 game in 2022, with 3 sacks on September 11, 2022.

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