Drew Brees has the most passing touchdowns, with 48 touchdowns in Week 8.

Interpreted as:

most tds thrown by a player in the first 2 weeks

	NAME	TD	WEEK	GP	CMP	ATT	PCT	YDS	AVG	YDS/G	INT	RTG	TD%	INT%	SCK	SCKY
1	Drew Brees D. Brees	48	WK 8	19	502	699	71.8	5,654	8.1	297.6	16	109.0	6.9	2.3	33	233
2	Tom Brady T. Brady	45	WK 8	20	470	715	65.7	5,565	7.8	278.3	6	106.8	6.3	0.8	48	304
3	Tom Brady T. Brady	44	WK 1	20	474	740	64.1	5,523	7.5	276.2	15	97.9	5.9	2.0	32	209
4	Drew Brees D. Brees	41	WK 15	19	486	719	67.6	5,412	7.5	284.8	13	101.2	5.7	1.8	32	240
5	Drew Brees D. Brees	41	WK 12	17	399	587	68.0	4,949	8.4	291.1	12	108.6	7.0	2.0	33	227
6	Drew Brees D. Brees	41	WK 1	19	471	707	66.6	5,566	7.9	292.9	15	100.9	5.8	2.1	24	169
7	Tom Brady T. Brady	41	WK 17	21	418	651	64.2	4,988	7.7	237.5	11	101.5	6.3	1.7	26	155
8	Tom Brady T. Brady	41	WK 12	21	508	799	63.6	5,925	7.4	282.1	15	95.2	5.1	1.9	34	199
9	Tom Brady T. Brady	41	WK 6	20	496	759	65.3	5,726	7.5	286.3	15	97.7	5.4	2.0	36	243
10	Brett Favre B. Favre	41	WK 4	17	361	568	63.6	4,156	7.3	244.5	19	95.7	7.2	3.3	25	150
11	Aaron Rodgers A. Rodgers	40	WK 7	14	339	471	72.0	3,950	8.4	282.1	6	120.0	8.5	1.3	17	124
12	Tom Brady T. Brady	40	WK 11	19	425	670	63.4	5,046	7.5	265.6	7	101.9	6.0	1.0	28	167
13	Tom Brady T. Brady	40	WK 7	18	433	662	65.4	4,702	7.1	261.2	9	100.7	6.0	1.4	29	193
14	Tom Brady T. Brady	40	WK 5	20	471	726	64.9	5,590	7.7	279.5	10	100.9	5.5	1.4	44	315
15	Tom Brady T. Brady	39	WK 14	21	487	782	62.3	5,802	7.4	276.3	13	94.6	5.0	1.7	37	216
16	Peyton Manning P. Manning	39	WK 10	17	394	627	62.8	4,546	7.3	267.4	23	90.1	6.2	3.7	16	110
17	Dan Marino D. Marino	39	WK 13	16	354	599	59.1	4,335	7.2	270.9	18	90.7	6.5	3.0	25	159
18	Drew Brees D. Brees	38	WK 14	17	458	676	67.8	4,826	7.1	283.9	16	97.2	5.6	2.4	22	163
19	Drew Brees D. Brees	38	WK 9	17	412	593	69.5	4,827	8.1	283.9	11	107.5	6.4	1.9	21	137
20	Tom Brady T. Brady	37	WK 16	20	416	644	64.6	4,443	6.9	222.2	13	95.4	5.7	2.0	31	199
21	Tom Brady T. Brady	37	WK 2	20	450	714	63.0	5,189	7.3	259.5	11	95.7	5.2	1.5	30	189
22	Brett Favre B. Favre	37	WK 3	18	424	676	62.7	4,908	7.3	272.7	19	91.1	5.5	2.8	41	314
23	Aaron Rodgers A. Rodgers	36	WK 4	16	342	510	67.1	4,147	8.1	259.2	11	106.4	7.1	2.2	36	232
24	Drew Brees D. Brees	36	WK 17	16	370	574	64.5	4,264	7.4	266.5	11	99.7	6.3	1.9	28	190
25	Tom Brady T. Brady	36	WK 3	19	502	735	68.3	5,647	7.7	297.2	8	102.8	4.9	1.1	39	261

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StatMuse has game-level data for passing touchdowns going back to the 1950 season.

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Dolphins - e	7	9	0	.438
Jets - e	3	13	0	.188
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Steelers	9	7	0	.563
Ravens	8	8	0	.500
Bengals - e	6	10	0	.375
Browns - e	4	12	0	.250
AFC South	W	L	T	PCT
Jaguars - x	12	4	0	.750
Texans - x	11	5	0	.688
Colts - e	8	8	0	.500
Titans - e	3	13	0	.188
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Cowboys - e	7	8	1	.469
Commanders - e	4	12	0	.250
Giants - e	3	13	0	.188
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Packers - w	9	6	1	.594
Vikings - e	8	8	0	.500
Lions - e	8	8	0	.500
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Buccaneers	7	9	0	.438
Falcons - e	7	9	0	.438
Saints - e	6	10	0	.375
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49ers - x	12	4	0	.750
Rams - w	11	5	0	.688
Cardinals - e	3	13	0	.188