Between January 18, 1941 and January 18, 2021, Jim Brown has the most scrimmage yards per game when playing 100+ games, with 125.5 per game.

most yards from scrimmage per game in last 80 years with a minimum of 100 games
Interpreted as:
most yards from scrimmage per game by a player in last 80 years with a minimum of 100 games

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