The San Francisco 49ers were 6-3 against the spread in the NFC against the NFC on the road in Week 1 between the 2002 and 2021 seasons.
| TEAM | ATS | ATS COV % | ATS AVG | O/U REC | O/U AVG | GP | W | L | T | TD | PTS | PPG | OPP PTS | OPP PPG | 1DWN | 3DWN% | 4DWN% | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 6-3 | 66.7 | +1.8 | 3-5-1 | +2.3 | 9 | 6 | 3 | 0 | 22 | 215 | 23.9 | 207 | 23.0 | 158 | 31.8 | 75.0 |
| 2 |  | Cardinals | 5-4-1 | 50 | -2.7 | 5-5 | +3.4 | 10 | 3 | 7 | 0 | 23 | 204 | 20.4 | 260 | 26.0 | 206 | 41.9 | 50.0 |
| 3 |  | Vikings | 4-3-1 | 50 | +2.6 | 4-4 | -2 | 8 | 3 | 5 | 0 | 17 | 161 | 20.1 | 166 | 20.8 | 142 | 38.5 | 50.0 |
| 4 |  | Falcons | 3-7 | 30 | -2.2 | 3-7 | -3.6 | 10 | 4 | 6 | 0 | 20 | 181 | 18.1 | 215 | 21.5 | 193 | 33.3 | 42.9 |
| 5 |  | Saints | 2-5 | 28.6 | -2.7 | 5-2 | +6.5 | 7 | 2 | 5 | 0 | 16 | 165 | 23.6 | 206 | 29.4 | 156 | 51.9 | 0.0 |
| 6 |  | Bears | 4-3 | 57.1 | -1.7 | 4-3 | -1.5 | 7 | 2 | 5 | 0 | 12 | 119 | 17.0 | 160 | 22.9 | 123 | 32.6 | 23.1 |
| 7 |  | Rams | 2-5 | 28.6 | -13.1 | 3-4 | -3.2 | 7 | 1 | 6 | 0 | 8 | 94 | 13.4 | 199 | 28.4 | 111 | 30.1 | 54.5 |
| 8 |  | Buccaneers | 4-4 | 50 | +5.8 | 4-4 | +0.6 | 8 | 4 | 4 | 0 | 21 | 179 | 22.4 | 171 | 21.4 | 141 | 39.8 | 50.0 |
| 9 |  | Giants | 1-8 | 11.1 | -6.6 | 7-2 | +4.5 | 9 | 1 | 8 | 0 | 21 | 177 | 19.7 | 275 | 30.6 | 167 | 35.5 | 41.7 |
| 10 |  | Lions | 3-3 | 50 | -0.8 | 4-2 | +5.3 | 6 | 2 | 3 | 1 | 16 | 136 | 22.7 | 161 | 26.8 | 109 | 23.8 | 50.0 |
| 11 |  | Cowboys | 3-4 | 42.9 | -0.6 | 3-4 | -3.9 | 7 | 2 | 5 | 0 | 16 | 136 | 19.4 | 153 | 21.9 | 158 | 38.6 | 37.5 |
| 12 |  | Seahawks | 3-5 | 37.5 | -0.6 | 3-5 | -6.6 | 8 | 4 | 4 | 0 | 15 | 153 | 19.1 | 149 | 18.6 | 147 | 34.5 | 60.0 |
| 13 |  | Packers | 5-4 | 55.6 | -2.8 | 4-5 | -1.8 | 9 | 5 | 4 | 0 | 22 | 185 | 20.6 | 219 | 24.3 | 178 | 41.4 | 50.0 |
| 14 |  | Eagles | 5-4 | 55.6 | +6.9 | 3-6 | -4 | 9 | 5 | 4 | 0 | 27 | 228 | 25.3 | 156 | 17.3 | 186 | 42.7 | 30.0 |
| 15 |  | Panthers | 3-2-1 | 50 | +4.3 | 2-4 | -4.6 | 6 | 3 | 3 | 0 | 12 | 119 | 19.8 | 105 | 17.5 | 116 | 38.5 | 33.3 |
| 16 |  | Redskins | 4-1 | 80 | +6.9 | 3-2 | +1.4 | 5 | 2 | 3 | 0 | 13 | 115 | 23.0 | 109 | 21.8 | 93 | 34.8 | 85.7 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |