Derrick Thomas and Leslie O'Neal were tied for the most games with 4.0+ sacks, with 4 games.

nfl most games with 4 sacks player
Interpreted as:
NFL most regular-season games with 4 or more defensive sacks player
ThomasO'NealWhiteJonesDonaldHoustonWakePorterMcCraryMartinSmithSmithDolemanMillardJacksonMecklenburgDentTaylorGastineauReddickJordanCrosby4432222222222222222111
NAMEGPSCKTKLASTCOMBSCKYINTINT YDSINT TDFFFRFR TD
Derrick ThomasDerrick Thomas421.00000
Leslie O'NealLeslie O'Neal417.00000
Reggie WhiteReggie White312.00000
Chandler JonesChandler Jones28.0921165000310
Aaron DonaldAaron Donald28.01211352000210
Justin HoustonJustin Houston28.51211349000220
Cameron WakeCameron Wake28.581955.5000200
Joey PorterJoey Porter28.01111244000100
Michael McCraryMichael McCrary28.00000
Wayne MartinWayne Martin28.00000
Anthony SmithAnthony Smith28.00000
Bruce SmithBruce Smith28.00000
Chris DolemanChris Doleman28.00000
Keith MillardKeith Millard28.00000
Rickey JacksonRickey Jackson28.00000
Karl MecklenburgKarl Mecklenburg28.00000
Richard DentRichard Dent29.00000
Lawrence TaylorLawrence Taylor28.00000
Mark GastineauMark Gastineau28.00000
Haason ReddickHaason Reddick15.050543000300
Cameron JordanCameron Jordan14.051619000000
Maxx CrosbyMaxx Crosby14.041542000100
Shaquil BarrettShaquil Barrett14.062823000200
Adrian ClaybornAdrian Clayborn16.060632000210
Calais CampbellCalais Campbell14.042617.5000000
StatMuse has game-level data for sacks going back to the 1982 season.

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