38 players are tied for the most safeties in a Week-1 game, with 1 safety. The first three are Zach Allen on September 8, 2024, Jaire Alexander on September 13, 2020 and Cameron Wake on September 8, 2019.

	NAME	SFTY	DATE	TM		OPP	TKL	AST	COMB	SCK	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Zach Allen Z. Allen	1	9/8/2024	DEN	@	SEA	1	1	2	0.0	0	0	0	0	0	0	0
2	Jaire Alexander J. Alexander	1	9/13/2020	GB	@	MIN	4	1	5	1.0	4	1	-4	0	0	0	0
3	Cameron Wake C. Wake	1	9/8/2019	TEN	@	CLE	2	1	3	2.5	20.5	0	0	0	0	0	0
4	Brian Poole B. Poole	1	9/8/2019	NYJ	vs	BUF	1	0	1	0.0	0	0	0	0	0	0	0
5	Morgan Fox M. Fox	1	9/10/2017	LAR	vs	IND	2	0	2	0.0	0	0	0	0	0	0	0
6	Tony McDaniel T. McDaniel	1	9/4/2014	SEA	vs	GB	1	2	3	0.0	0	0	0	0	0	0	0
7	Trent Cole T. Cole	1	9/9/2013	PHI	@	WAS	4	1	5	0.0	0	0	0	0	1	0	0
8	J.T. Thomas	1	9/8/2013	JAX	vs	KC	0	0	0	0.0	0	0	0	0	0	0	0
9	Greg Hardy G. Hardy	1	9/12/2010	CAR	@	NYG	3	1	4	0.0	0	0	0	0	1	0	0
10	Danieal Manning D. Manning	1	9/13/2009	CHI	@	GB	6	0	6	1.0	11	0	0	0	0	0	0
11	Adewale Ogunleye A. Ogunleye	1	9/7/2008	CHI	@	IND	5	1	6	0.0	0	0	0	0	0	0	0
12	Ty Warren T. Warren	1	9/10/2006	NE	vs	BUF	2	4	6	1.0	8	0	0	0	0	0	0
13	Seth Payne S. Payne	1	9/8/2002	HOU	vs	DAL	6	0	6	1.0	4	0	0	0	0	0	0
14	Darrell Russell D. Russell	1	9/3/2000	OAK	vs	SD				0.0		0	0	0			0
15	Ronnie Bradford R. Bradford	1	9/6/1998	ATL	@	CAR				0.0		0	0	0			0
16	Derrick Thomas D. Thomas	1	9/6/1998	KC	vs	OAK				6.0		0	0	0			0
17	Darryl Williams D. Williams	1	9/3/1995	CIN	@	IND				0.0		0	0	0			0
18	Issiac Holt I. Holt	1	9/7/1992	DAL	vs	WAS				0.0		0	0	0			0
19	David Fulcher D. Fulcher	1	9/9/1990	CIN	vs	NYJ				1.0		1	0	0			0
20	Stefon Adams S. Adams	1	9/10/1989	RAI	vs	SD				0.0		0	0	0			0
21	Bruce Clark B. Clark	1	9/13/1987	NO	vs	CLE				1.0		0	0	0			0
22	Brett Maxie B. Maxie	1	9/13/1987	NO	vs	CLE				1.0		0	0	0			0
23	Greg Townsend G. Townsend	1	9/7/1986	RAI	@	DEN				1.0		0	0	0			0
24	Don Blackmon D. Blackmon	1	9/8/1985	NE	vs	GB				3.0		0	0	0			0
25	Rick Bryan R. Bryan	1	9/2/1984	ATL	@	NO				1.5		0	0	0			0

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Results may be incomplete. StatMuse has complete game-level data for safeties going back to the 1960 season.

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Jets - e	3	14	0	.176
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Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
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Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
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