The San Francisco 49ers have a 21-26 record against the AFC in the regular-season and playoffs since 2015.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/20/2015 | 0-1 |  SF | @ |  PIT | L 18-43 | .000 | 2 | 27 | 409 | 453 | 41.2 | 60.0 |
| 2 | | 49ers | 10/18/2015 | 1-0 | SF | vs |  BAL | W 25-20 | 1.000 | 2 | 15 | 391 | 420 | 38.5 | |
| 3 | | 49ers | 12/13/2015 | 0-1 | SF | @ |  CLE | L 10-24 | .000 | 1 | 15 | 221 | 481 | 15.4 | 33.3 |
| 4 | | 49ers | 12/20/2015 | 0-1 | SF | vs |  CIN | L 14-24 | .000 | 2 | 17 | 318 | 242 | 14.3 | 100.0 |
| 5 | | 49ers | 10/16/2016 | 0-1 | SF | @ |  BUF | L 16-45 | .000 | 1 | 16 | 300 | 492 | 23.1 | 0.0 |
| 6 | | 49ers | 11/20/2016 | 0-1 | SF | vs |  NE | L 17-30 | .000 | 2 | 20 | 299 | 444 | 35.7 | |
| 7 | | 49ers | 11/27/2016 | 0-1 | SF | @ |  MIA | L 24-31 | .000 | 3 | 25 | 475 | 358 | 50.0 | 100.0 |
| 8 | | 49ers | 12/11/2016 | 0-1 | SF | vs |  NYJ | L 17-23 | .000 | 2 | 17 | 364 | 404 | 16.7 | 0.0 |
| 9 | | 49ers | 10/8/2017 | 0-1 | SF | @ |  IND | L 23-26 | .000 | 2 | 23 | 402 | 447 | 28.6 | 100.0 |
| 10 | | 49ers | 12/10/2017 | 1-0 | SF | @ |  HOU | W 26-16 | 1.000 | 2 | 20 | 416 | 311 | 18.2 | |
| 11 | | 49ers | 12/17/2017 | 1-0 | SF | vs |  TEN | W 25-23 | 1.000 | 1 | 23 | 414 | 328 | 50.0 | |
| 12 | | 49ers | 12/24/2017 | 1-0 | SF | vs |  JAX | W 44-33 | 1.000 | 6 | 26 | 369 | 472 | 66.7 | |
| 13 | | 49ers | 9/23/2018 | 0-1 | SF | @ |  KC | L 27-38 | .000 | 3 | 26 | 406 | 384 | 22.2 | 100.0 |
| 14 | | 49ers | 9/30/2018 | 0-1 | SF | @ |  LAC | L 27-29 | .000 | 3 | 22 | 364 | 368 | 41.7 | |
| 15 | | 49ers | 11/1/2018 | 1-0 | SF | vs |  OAK | W 34-3 | 1.000 | 4 | 18 | 405 | 242 | 41.7 | |
| 16 | | 49ers | 12/9/2018 | 1-0 | SF | vs |  DEN | W 20-14 | 1.000 | 2 | 24 | 389 | 274 | 30.8 | 0.0 |
| 17 | | 49ers | 9/15/2019 | 1-0 | SF | @ | CIN | W 41-17 | 1.000 | 5 | 27 | 571 | 316 | 55.6 | |
| 18 | | 49ers | 9/22/2019 | 1-0 | SF | vs | PIT | W 24-20 | 1.000 | 3 | 26 | 436 | 239 | 54.5 | |
| 19 | | 49ers | 10/7/2019 | 1-0 | SF | vs | CLE | W 31-3 | 1.000 | 4 | 22 | 446 | 180 | 37.5 | 100.0 |
| 20 | | 49ers | 12/1/2019 | 0-1 | SF | @ | BAL | L 17-20 | .000 | 2 | 15 | 331 | 283 | 33.3 | 50.0 |
| 21 | | 49ers | 2/2/2020 | 0-1 | SF | @ | KC | L 20-31 | .000 | 2 | 21 | 351 | 397 | 37.5 | 0.0 |
| 22 | | 49ers | 9/20/2020 | 1-0 | SF | @ |  NYJ | W 31-13 | 1.000 | 4 | 17 | 359 | 277 | 53.8 | |
| 23 | | 49ers | 10/11/2020 | 0-1 | SF | vs | MIA | L 17-43 | .000 | 2 | 19 | 259 | 436 | 20.0 | 0.0 |
| 24 | | 49ers | 10/25/2020 | 1-0 | SF | @ | NE | W 33-6 | 1.000 | 4 | 26 | 467 | 241 | 55.6 | |
| 25 | | 49ers | 12/7/2020 | 0-1 | SF | vs | BUF | L 24-34 | .000 | 3 | 24 | 402 | 449 | 54.5 | 0.0 |
| Average | .447 | 2.5 | 21.0 | 376.6 | 341.4 | 38.6 | 1.9 | ||||||||
| Total | 21-26 | .447 | 118 | 986 | 17,698 | 16,047 | 38.6 | 52.2 | |||||||
More 49ers Stats
Team Rankings
PPG
21.2
21st
OPP PPG
19.6
8th
RUSH YDS/G
85.2
29th
PASS YDS/G
298.2
2nd
Rams 
Cardinals 
NYG 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 0 | 0 | 1.000 |
 Commanders | 2 | 2 | 0 | .500 |
| NFC North | W | L | T | PCT |
 Lions | 3 | 1 | 0 | .750 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 1 | 0 | .750 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 1 | 0 | .800 |
 Seahawks | 3 | 1 | 0 | .750 |
DAL 
NYJ 
NO 
