The San Francisco 49ers have a record of 35-36 against the AFC in the regular-season and playoffs since 2009.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/25/2009 | 0-1 |  SF | @ |  HOU | L 21-24 | .000 | 3 | 17 | 297 | 336 | 36.4 | 0.0 |
| 2 | | 49ers | 11/1/2009 | 0-1 | SF | @ |  IND | L 14-18 | .000 | 2 | 16 | 295 | 410 | 20.0 | |
| 3 | | 49ers | 11/8/2009 | 0-1 | SF | vs |  TEN | L 27-34 | .000 | 3 | 25 | 358 | 315 | 30.8 | 100.0 |
| 4 | | 49ers | 11/29/2009 | 1-0 | SF | vs |  JAX | W 20-3 | 1.000 | 2 | 15 | 284 | 357 | 50.0 | 100.0 |
| 5 | | 49ers | 9/26/2010 | 0-1 | SF | @ |  KC | L 10-31 | .000 | 1 | 11 | 251 | 457 | 23.5 | 66.7 |
| 6 | | 49ers | 10/17/2010 | 1-0 | SF | vs |  OAK | W 17-9 | 1.000 | 2 | 17 | 349 | 179 | 41.2 | |
| 7 | | 49ers | 10/31/2010 | 1-0 | SF | vs |  DEN | W 24-16 | 1.000 | 3 | 16 | 339 | 398 | 38.5 | |
| 8 | | 49ers | 12/16/2010 | 0-1 | SF | @ |  SD | L 7-34 | .000 | 1 | 11 | 192 | 374 | 16.7 | 0.0 |
| 9 | | 49ers | 9/25/2011 | 1-0 | SF | @ |  CIN | W 13-8 | 1.000 | 1 | 16 | 226 | 228 | 33.3 | 0.0 |
| 10 | | 49ers | 10/30/2011 | 1-0 | SF | vs |  CLE | W 20-10 | 1.000 | 2 | 19 | 348 | 290 | 40.0 | 0.0 |
| 11 | | 49ers | 11/24/2011 | 0-1 | SF | @ |  BAL | L 6-16 | .000 | 0 | 12 | 170 | 253 | 16.7 | 50.0 |
| 12 | | 49ers | 12/19/2011 | 1-0 | SF | vs |  PIT | W 20-3 | 1.000 | 2 | 17 | 287 | 389 | 30.8 | |
| 13 | | 49ers | 9/30/2012 | 1-0 | SF | @ |  NYJ | W 34-0 | 1.000 | 4 | 26 | 381 | 145 | 33.3 | 100.0 |
| 14 | | 49ers | 10/7/2012 | 1-0 | SF | vs |  BUF | W 45-3 | 1.000 | 6 | 29 | 621 | 204 | 63.6 | 100.0 |
| 15 | | 49ers | 12/9/2012 | 1-0 | SF | vs |  MIA | W 27-13 | 1.000 | 3 | 20 | 321 | 227 | 20.0 | |
| 16 | | 49ers | 12/16/2012 | 1-0 | SF | @ |  NE | W 41-34 | 1.000 | 5 | 19 | 388 | 520 | 35.7 | 50.0 |
| 17 | | 49ers | 2/3/2013 | 0-1 | SF | vs | BAL | L 31-34 | .000 | 3 | 23 | 468 | 367 | 22.2 | 0.0 |
| 18 | | 49ers | 9/22/2013 | 0-1 | SF | vs | IND | L 7-27 | .000 | 1 | 14 | 254 | 336 | 25.0 | 100.0 |
| 19 | | 49ers | 10/6/2013 | 1-0 | SF | vs | HOU | W 34-3 | 1.000 | 4 | 17 | 284 | 313 | 36.4 | 0.0 |
| 20 | | 49ers | 10/20/2013 | 1-0 | SF | @ | TEN | W 31-17 | 1.000 | 4 | 19 | 349 | 368 | 50.0 | |
| 21 | | 49ers | 10/27/2013 | 1-0 | SF | @ | JAX | W 42-10 | 1.000 | 6 | 25 | 398 | 318 | 66.7 | 100.0 |
| 22 | | 49ers | 10/5/2014 | 1-0 | SF | vs | KC | W 22-17 | 1.000 | 1 | 22 | 357 | 265 | 37.5 | 100.0 |
| 23 | | 49ers | 10/19/2014 | 0-1 | SF | @ | DEN | L 17-42 | .000 | 2 | 22 | 310 | 419 | 23.1 | 50.0 |
| 24 | | 49ers | 12/7/2014 | 0-1 | SF | @ | OAK | L 13-24 | .000 | 1 | 18 | 248 | 330 | 27.3 | 100.0 |
| 25 | | 49ers | 12/20/2014 | 0-1 | SF | vs | SD | L 35-38 | .000 | 5 | 21 | 447 | 446 | 45.5 | 0.0 |
| Average | .493 | 2.6 | 20.2 | 359.6 | 337.5 | 36.9 | 1.2 | ||||||||
| Total | 35-36 | .493 | 183 | 1,431 | 25,531 | 23,966 | 36.9 | 53.3 | |||||||
More 49ers Stats
Team Rankings
PPG
22.9
13th
OPP PPG
25.6
29th
RUSH YDS/G
127.2
12th
PASS YDS/G
260.2
4th
Cardinals 
NFL 2024 Leaders
NFL 2024 Rankings
NFL Fantasy 2024
NFL 2024 Betting
NFL 2024 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 14 | 3 | 0 | .824 |
 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
 Lions | 15 | 2 | 0 | .882 |
 Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
 Buccaneers | 10 | 7 | 0 | .588 |
 Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
 Rams | 10 | 7 | 0 | .588 |
 Seahawks | 10 | 7 | 0 | .588 |
