O.J. Simpson had 350 carries for 1,883 yards and scored 23 touchdowns in 16 games in his first 16 games between the 1975 and 1976 seasons.
| NAME | DATE | TM | OPP | RUSH YDS | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 9/21/1975 | vs | 173 | 32 | 5.4 | 2 | 5 | 1 | 5.0 | 0 | |||
| 2 | | O.J. Simpson | 9/28/1975 | @ | 227 | 28 | 8.1 | 1 | 0 | 0 | 0 | ||||
| 3 | | O.J. Simpson | 10/5/1975 | vs | 138 | 26 | 5.3 | 1 | 0 | 0 | 0 | ||||
| 4 | | O.J. Simpson | 10/12/1975 | @ | 159 | 32 | 5.0 | 1 | 14 | 1 | 14.0 | 0 | |||
| 5 | | O.J. Simpson | 10/20/1975 | vs | 126 | 34 | 3.7 | 1 | 0 | 0 | 0 | ||||
| 6 | | O.J. Simpson | 10/26/1975 | vs | 88 | 19 | 4.6 | 1 | 16 | 2 | 8.0 | 0 | |||
| 7 | | O.J. Simpson | 11/2/1975 | @ | 94 | 21 | 4.5 | 0 | 66 | 2 | 33.0 | 1 | |||
| 8 | | O.J. Simpson | 11/9/1975 | vs | 123 | 19 | 6.5 | 1 | 71 | 3 | 23.7 | 2 | |||
| 9 | | O.J. Simpson | 11/17/1975 | @ | 197 | 17 | 11.6 | 2 | 21 | 2 | 10.5 | 0 | |||
| 10 | | O.J. Simpson | 11/23/1975 | vs | 69 | 27 | 2.6 | 2 | 22 | 4 | 5.5 | 2 | |||
| 11 | | O.J. Simpson | 11/27/1975 | @ | 85 | 23 | 3.7 | 1 | 0 | 0 | 0 | ||||
| 12 | | O.J. Simpson | 12/7/1975 | @ | 96 | 18 | 5.3 | 1 | 117 | 8 | 14.6 | 1 | |||
| 13 | | O.J. Simpson | 12/14/1975 | @ | 185 | 21 | 8.8 | 1 | 28 | 2 | 14.0 | 0 | |||
| 14 | | O.J. Simpson | 12/20/1975 | vs | 57 | 12 | 4.8 | 1 | 66 | 3 | 22.0 | 1 | |||
| 15 | | O.J. Simpson | 9/13/1976 | vs | 28 | 5 | 5.6 | 0 | 43 | 1 | 43.0 | 0 | |||
| 16 | | O.J. Simpson | 9/19/1976 | vs | 38 | 16 | 2.4 | 0 | 25 | 3 | 8.3 | 0 | |||
| Average | 117.7 | 21.9 | 5.4 | 1.0 | 30.9 | 2.0 | 15.4 | 0.4 | |||||||
| Total | 1,883 | 350 | 5.4 | 16 | 494 | 32 | 15.4 | 7 |
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |