O.J. Simpson rushed for his most yards in a game against the Lions on November 25, 1976, with 273 yards.

Interpreted as:

O.J. Simpson highest rushing yards in a regular-season game

	NAME	RUSH YDS	DATE	TM		OPP	ATT	YPC	RUSH TD	REC YDS	REC	AVG	REC TD
1	O.J. Simpson	273	11/25/1976	BUF	@	DET	29	9.4	2	0	0		0
2	O.J. Simpson	250	9/16/1973	BUF	@	NE	29	8.6	2	0	0		0
3	O.J. Simpson	227	9/28/1975	BUF	@	PIT	28	8.1	1	0	0		0
4	O.J. Simpson	219	12/9/1973	BUF	vs	NE	22	10.0	1	0	0		0
5	O.J. Simpson	203	12/5/1976	BUF	@	MIA	24	8.5	1	12	2	6.0	0
6	O.J. Simpson	200	12/16/1973	BUF	@	NYJ	34	5.9	1	0	0		0
7	O.J. Simpson	197	11/17/1975	BUF	@	CIN	17	11.6	2	21	2	10.5	0
8	O.J. Simpson	189	10/29/1972	BUF	vs	PIT	22	8.6	1	7	3	2.3	0
9	O.J. Simpson	185	12/14/1975	BUF	@	NE	21	8.8	1	28	2	14.0	0
10	O.J. Simpson	173	9/21/1975	BUF	vs	NYJ	32	5.4	2	5	1	5.0	0
11	O.J. Simpson	171	12/12/1976	BUF	@	BAL	28	6.1	1	18	1	18.0	0
12	O.J. Simpson	171	10/7/1973	BUF	vs	PHI	27	6.3	1	33	3	11.0	0
13	O.J. Simpson	166	10/31/1976	BUF	vs	NYJ	29	5.7	0	0	0		0
14	O.J. Simpson	166	10/14/1973	BUF	vs	BAL	22	7.5	2	0	0		0
15	O.J. Simpson	159	10/12/1975	BUF	@	BAL	32	5.0	1	14	1	14.0	0
16	O.J. Simpson	157	10/29/1973	BUF	vs	KC	39	4.0	2	0	0		0
17	O.J. Simpson	144	10/15/1972	BUF	@	OAK	28	5.1	0	9	2	4.5	0
18	O.J. Simpson	138	10/16/1977	BUF	vs	ATL	23	6.0	0	5	1	5.0	0
19	O.J. Simpson	138	10/5/1975	BUF	vs	DEN	26	5.3	1	0	0		0
20	O.J. Simpson	138	9/24/1972	BUF	vs	SF	29	4.8	0	20	2	10.0	0
21	O.J. Simpson	137	12/2/1973	BUF	@	ATL	24	5.7	0	0	0		0
22	O.J. Simpson	130	10/3/1976	BUF	vs	KC	24	5.4	2	8	1	8.0	0
23	O.J. Simpson	127	10/13/1974	BUF	@	BAL	23	5.5	0	8	1	8.0	0
24	O.J. Simpson	126	10/20/1975	BUF	vs	NYG	34	3.7	1	0	0		0
25	O.J. Simpson	124	11/25/1973	BUF	@	BAL	15	8.3	1	0	0		0

Unlock 2x data

Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.

More Bills Stats

Team Leaders

PASS

3,406

Allen

RUSH

1,532

Cook

REC

684

Shakir

Team Rankings

PPG

28.9

4th

OPP PPG

22.9

15th

RUSH YDS/G

158.9

1st

PASS YDS/G

230.7

16th

2025 Division Standings

TEAM	W	L	PCT
Patriots	12	3	.800
Bills	11	4	.733
Dolphins	6	9	.400
Jets	3	12	.200

Schedule

DATE	MATCHUP			TIME (ET)
Sun 12/28	PHI	@	BUF	4:25 PM
Sun 1/4	NYJ	@	BUF	1:00 PM

Last Game

Bills

11 - 4

Final

Browns

3 - 12

Sun 21 Dec 2025

NFL 2025 Leaders

Pass Yards Leaders

4,179

Stafford

4,175

Prescott

4,036

Goff

Rush Yards Leaders

1,532

Cook

1,489

Taylor

1,267

Achane

Rec Yards Leaders

1,637

Smith-Njigba

1,592

Nacua

1,342

Pickens

Pass TD Leaders

40

Stafford

32

Goff

28

Prescott

Rush TD Leaders

17

Taylor

13

Gibbs

13

Jacobs

Rec TD Leaders

14

Adams

11

St. Brown

10

Smith-Njigba

QB Rating Leaders

112.1

Stafford

109.4

Goff

108.5

Maye

Sack Leaders

22.0

Garrett

15.0

Burns

13.0

Tuipulotu

NFL 2025 Rankings

PPG Rankings

30.5

30.1

29.5

28.9

28.3

27.9

Opp PPG Rankings

16.6

18.6

19.3

19.6

19.7

19.9

Total Yards Rankings

396.7

393.1

378.7

373.1

371.5

370.1

Rush Yards Rankings

158.9

152.1

147.9

133.9

126.3

125.3

Pass Yards Rankings

285.7

278.6

269.3

263.9

259.2

258.1

Sack Leaders

63.0

50.0

49.0

43.0

42.0

41.0

NFL Fantasy 2025

Fantasy RB Rankings

298

Taylor

284.8

McCaffrey

268.2

Gibbs

Fantasy WR Rankings

225.3

Smith-Njigba

219.3

Nacua

190.2

Pickens

Fantasy TE Rankings

169.8

McBride

118.3

Goedert

115.4

Pitts

Fantasy K Rankings

184

Myers

165.6

Aubrey

163

Dicker

NFL 2025 Betting

Best Record ATS

11-4

10-4-1

10-5

Worst Record ATS

5-10

5-9-1

6-9

NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - x	12	3	0	.800
Bills - x	11	4	0	.733
Dolphins - e	6	9	0	.400
Jets - e	3	12	0	.200
AFC North	W	L	T	PCT
Steelers	9	6	0	.600
Ravens	7	8	0	.467
Bengals - e	5	10	0	.333
Browns - e	3	12	0	.200
AFC South	W	L	T	PCT
Jaguars - x	11	4	0	.733
Texans	10	5	0	.667
Colts	8	7	0	.533
Titans - e	3	12	0	.200
AFC West	W	L	T	PCT
Broncos - x	12	3	0	.800
Chargers - x	11	4	0	.733
Chiefs - e	6	9	0	.400
Raiders - e	2	13	0	.133

NFC East	W	L	T	PCT
Eagles - y	10	5	0	.667
Cowboys - e	6	8	1	.433
Commanders - e	4	11	0	.267
Giants - e	2	13	0	.133
NFC North	W	L	T	PCT
Bears - x	11	4	0	.733
Packers	9	5	1	.633
Lions	8	7	0	.533
Vikings - e	7	8	0	.467
NFC South	W	L	T	PCT
Panthers	8	7	0	.533
Buccaneers	7	8	0	.467
Falcons - e	6	9	0	.400
Saints - e	5	10	0	.333
NFC West	W	L	T	PCT
Seahawks - x	12	3	0	.800
49ers - x	11	4	0	.733
Rams - x	11	4	0	.733
Cardinals - e	3	12	0	.200