O.J. Simpson had his most rushing yards in a game versus the Lions on November 25, 1976, with 273 yards.
Interpreted as:
O.J. Simpson most rushing yards in a regular-season game| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 273 | 11/25/1976 | @ | 29 | 9.4 | 2 | 0 | 0 | 0 | ||||
| 2 | | O.J. Simpson | 250 | 9/16/1973 | @ | 29 | 8.6 | 2 | 0 | 0 | 0 | ||||
| 3 | | O.J. Simpson | 227 | 9/28/1975 | @ | 28 | 8.1 | 1 | 0 | 0 | 0 | ||||
| 4 | | O.J. Simpson | 219 | 12/9/1973 | vs | 22 | 10.0 | 1 | 0 | 0 | 0 | ||||
| 5 | | O.J. Simpson | 203 | 12/5/1976 | @ | 24 | 8.5 | 1 | 12 | 2 | 6.0 | 0 | |||
| 6 | | O.J. Simpson | 200 | 12/16/1973 | @ | 34 | 5.9 | 1 | 0 | 0 | 0 | ||||
| 7 | | O.J. Simpson | 197 | 11/17/1975 | @ | 17 | 11.6 | 2 | 21 | 2 | 10.5 | 0 | |||
| 8 | | O.J. Simpson | 189 | 10/29/1972 | vs | 22 | 8.6 | 1 | 7 | 3 | 2.3 | 0 | |||
| 9 | | O.J. Simpson | 185 | 12/14/1975 | @ | 21 | 8.8 | 1 | 28 | 2 | 14.0 | 0 | |||
| 10 | | O.J. Simpson | 173 | 9/21/1975 | vs | 32 | 5.4 | 2 | 5 | 1 | 5.0 | 0 | |||
| 11 | | O.J. Simpson | 171 | 12/12/1976 | @ | 28 | 6.1 | 1 | 18 | 1 | 18.0 | 0 | |||
| 12 | | O.J. Simpson | 171 | 10/7/1973 | vs | 27 | 6.3 | 1 | 33 | 3 | 11.0 | 0 | |||
| 13 | | O.J. Simpson | 166 | 10/31/1976 | vs | 29 | 5.7 | 0 | 0 | 0 | 0 | ||||
| 14 | | O.J. Simpson | 166 | 10/14/1973 | vs | 22 | 7.5 | 2 | 0 | 0 | 0 | ||||
| 15 | | O.J. Simpson | 159 | 10/12/1975 | @ | 32 | 5.0 | 1 | 14 | 1 | 14.0 | 0 | |||
| 16 | | O.J. Simpson | 157 | 10/29/1973 | vs | 39 | 4.0 | 2 | 0 | 0 | 0 | ||||
| 17 | | O.J. Simpson | 144 | 10/15/1972 | @ | 28 | 5.1 | 0 | 9 | 2 | 4.5 | 0 | |||
| 18 | | O.J. Simpson | 138 | 10/16/1977 | vs | 23 | 6.0 | 0 | 5 | 1 | 5.0 | 0 | |||
| 19 | | O.J. Simpson | 138 | 10/5/1975 | vs | 26 | 5.3 | 1 | 0 | 0 | 0 | ||||
| 20 | | O.J. Simpson | 138 | 9/24/1972 | vs | 29 | 4.8 | 0 | 20 | 2 | 10.0 | 0 | |||
| 21 | | O.J. Simpson | 137 | 12/2/1973 | @ | 24 | 5.7 | 0 | 0 | 0 | 0 | ||||
| 22 | | O.J. Simpson | 130 | 10/3/1976 | vs | 24 | 5.4 | 2 | 8 | 1 | 8.0 | 0 | |||
| 23 | | O.J. Simpson | 127 | 10/13/1974 | @ | 23 | 5.5 | 0 | 8 | 1 | 8.0 | 0 | |||
| 24 | | O.J. Simpson | 126 | 10/20/1975 | vs | 34 | 3.7 | 1 | 0 | 0 | 0 | ||||
| 25 | | O.J. Simpson | 124 | 11/25/1973 | @ | 15 | 8.3 | 1 | 0 | 0 | 0 | ||||
BALResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More Bills Stats
Team Leaders 
PASS
273
Allen
RUSH
46
Cook
REC
82
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
