The Carolina Panthers have a record of 6-4 against the spread in their last 10 games against the 49ers.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Panthers | 11/14/2004 | 1-0 | @ | W 37-27 | +1 | +11 (Y) | 41.5 | +22.5 (O) | 4 | 17 | 358 | 357 | 22.2 | |||||
| 2 | | Panthers | 12/2/2007 | 1-0 | -165 | vs | +145 | W 31-14 | -3 | +14 (Y) | 35.5 | +9.5 (O) | 4 | 20 | 323 | 195 | 50.0 | |||
| 3 | | Panthers | 10/24/2010 | 1-0 | +110 | vs | -130 | W 23-20 | +2.5 | +5.5 (Y) | 35.5 | +7.5 (O) | 2 | 22 | 379 | 282 | 46.7 | 0.0 | ||
| 4 | | Panthers | 11/10/2013 | 1-0 | +220 | @ | -260 | W 10-9 | +6 | +7 (Y) | 43 | -24 (U) | 1 | 15 | 250 | 151 | 41.2 | |||
| 5 | | Panthers | 1/12/2014 | 0-1 | +105 | vs | -125 | L 10-23 | +1 | -12 (N) | 41.5 | -8.5 (U) | 1 | 18 | 325 | 315 | 60.0 | 0.0 | ||
| 6 | | Panthers | 9/18/2016 | 1-0 | -625 | vs | +450 | W 46-27 | -12 | +7 (Y) | 44.5 | +28.5 (O) | 5 | 26 | 529 | 302 | 46.7 | |||
| 7 | | Panthers | 9/10/2017 | 1-0 | -200 | @ | +185 | W 23-3 | -4.5 | +15.5 (Y) | 45 | -19 (U) | 2 | 20 | 287 | 217 | 53.8 | |||
| 8 | | Panthers | 10/27/2019 | 0-1 | +172 | @ | -209 | L 13-51 | +4 | -34 (N) | 40.5 | +23.5 (O) | 1 | 12 | 230 | 388 | 15.4 | 0.0 | ||
| 9 | | Panthers | 10/9/2022 | 0-1 | +211 | vs | -261 | L 15-37 | +6 | -16 (N) | 39.5 | +12.5 (O) | 1 | 15 | 308 | 397 | 20.0 | 60.0 | ||
| 10 | | Panthers | 11/24/2025 | 0-1 | +307 | @ | -386 | L 9-20 | +7.5 | -3.5 (N) | 49.5 | -20.5 (U) | 1 | 12 | 230 | 340 | 14.3 | |||
| Average | 6.0 | 2.2 | 17.7 | 321.9 | 294.4 | 38.6 | 0.1 | |||||||||||||
| Total | 6-4 | 22 | 177 | 3,219 | 2,944 | 38.6 | 33.3 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
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More Panthers Stats
Team Leaders 
PASS
3,011
Young
RUSH
1,076
Dowdle
REC
1,014
McMillan
Team Rankings
PPG
18.3
27th
OPP PPG
22.4
15th
RUSH YDS/G
116.3
19th
PASS YDS/G
194.4
27th
2025 Division Standings
| TEAM | W | L | T | PCT |
|---|---|---|---|---|
8 | 9 | 0 | .471 | |
8 | 9 | 0 | .471 | |
 Panthers | 8 | 9 | 0 | .471 |
6 | 11 | 0 | .353 |
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
| Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |