The Carolina Panthers have a record of 7-3 against the spread as underdogs versus the 49ers on the road all-time.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Panthers | 11/5/1995 | 1-0 |  CAR | @ |  SF | W 13-7 | +15 | +21 (Y) | 40.5 | -20.5 (U) | 1 | 13 | 204 | 404 | 47.1 | |||
| 2 | | Panthers | 12/8/1996 | 1-0 | CAR | @ | SF | W 30-24 | +10 | +16 (Y) | 37.5 | +16.5 (O) | 3 | 22 | 382 | 450 | 41.2 | |||
| 3 | | Panthers | 11/16/1997 | 1-0 | CAR | @ | SF | L 19-27 | +9.5 | +1.5 (Y) | 37 | +9 (O) | 2 | 18 | 254 | 320 | 40.0 | 100.0 | ||
| 4 | | Panthers | 11/8/1998 | 1-0 | CAR | @ | SF | L 23-25 | +12 | +10 (Y) | 43 | +5 (O) | 2 | 16 | 287 | 366 | 41.2 | |||
| 5 | | Panthers | 10/17/1999 | 1-0 | CAR | @ | SF | W 31-29 | +4.5 | +6.5 (Y) | 44 | +16 (O) | 4 | 18 | 383 | 333 | 40.0 | |||
| 6 | | Panthers | 10/7/2001 | 0-1 | CAR | @ | SF | L 14-24 | +7 | -3 (N) | 45 | -7 (U) | 2 | 17 | 336 | 353 | 35.7 | 50.0 | ||
| 7 | | Panthers | 11/14/2004 | 1-0 | CAR | @ | SF | W 37-27 | +1 | +11 (Y) | 41.5 | +22.5 (O) | 4 | 17 | 358 | 357 | 22.2 | |||
| 8 | | Panthers | 11/10/2013 | 1-0 | CAR | +220 | @ | SF | -260 | W 10-9 | +6 | +7 (Y) | 43 | -24 (U) | 1 | 15 | 250 | 151 | 41.2 | |
| 9 | | Panthers | 10/27/2019 | 0-1 | CAR | +172 | @ | SF | -209 | L 13-51 | +4 | -34 (N) | 40.5 | +23.5 (O) | 1 | 12 | 230 | 388 | 15.4 | 0.0 |
| 10 | | Panthers | 11/24/2025 | 0-1 | CAR | +307 | @ | SF | -386 | L 9-20 | +7.5 | -3.5 (N) | 49.5 | -20.5 (U) | 1 | 12 | 230 | 340 | 14.3 | |
| Average | 7.0 | 2.1 | 16.0 | 291.4 | 346.2 | 36.0 | 13.3 | |||||||||||||
| Total | 7-3 | 21 | 160 | 2,914 | 3,462 | 36.0 | 40.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More Panthers Stats
Team Rankings
PPG
18.0
28th
OPP PPG
22.4
14th
RUSH YDS/G
122.3
11th
PASS YDS/G
202.0
26th
2025 Division Standings
| TEAM | W | L | T | PCT |
|---|---|---|---|---|
 Buccaneers | 6 | 5 | 0 | .545 |
| Panthers | 6 | 6 | 0 | .500 |
 Falcons | 4 | 7 | 0 | .364 |
 Saints | 2 | 9 | 0 | .182 |
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