Patrick Mahomes made his most passing attempts in a game versus the Titans on November 6, 2022, with 68 attempts.

Interpreted as:

Patrick Mahomes most passing yard single pass in a regular-season game

	NAME	ATT	YDS	DATE	TM		OPP	CMP	PCT	AVG	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Patrick Mahomes P. Mahomes	68	446	11/6/2022	KC	vs	TEN	43	63.2	6.6	1	1	80.9	1.5	1.5	4	24
2	Patrick Mahomes P. Mahomes	54	272	10/10/2021	KC	vs	BUF	33	61.1	5.0	2	2	70.9	3.7	3.7	2	0
3	Patrick Mahomes P. Mahomes	53	377	12/9/2018	KC	vs	BAL	35	66.0	7.1	2	1	91.5	3.8	1.9	3	29
4	Patrick Mahomes P. Mahomes	50	406	11/14/2021	KC	@	LV	35	70.0	8.1	5	0	127.6	10.0	0.0	0	0
5	Patrick Mahomes P. Mahomes	50	446	11/10/2019	KC	@	TEN	36	72.0	8.9	3	0	119.3	6.0	0.0	2	13
6	Patrick Mahomes P. Mahomes	49	462	11/29/2020	KC	@	TB	37	75.5	9.4	3	0	124.7	6.1	0.0	2	6
7	Patrick Mahomes P. Mahomes	48	275	11/1/2021	KC	vs	NYG	29	60.4	5.7	1	1	74.6	2.1	2.1	2	14
8	Patrick Mahomes P. Mahomes	47	410	12/16/2021	KC	@	LAC	31	66.0	8.7	3	1	105.8	6.4	2.1	1	0
9	Patrick Mahomes P. Mahomes	47	397	10/17/2021	KC	@	WAS	32	68.1	8.4	2	2	90.5	4.3	4.3	3	7
10	Patrick Mahomes P. Mahomes	47	254	12/20/2020	KC	@	NO	26	55.3	5.4	3	0	92.0	6.4	0.0	4	22
11	Patrick Mahomes P. Mahomes	47	302	9/20/2020	KC	@	LAC	27	57.4	6.4	2	0	90.9	4.3	0.0	1	13
12	Patrick Mahomes P. Mahomes	46	352	11/23/2025	KC	vs	IND	29	63.0	7.7	0	1	77.4	0.0	2.2	4	6
13	Patrick Mahomes P. Mahomes	46	306	11/29/2024	KC	vs	LV	26	56.5	6.7	1	0	84.1	2.2	0.0	5	40
14	Patrick Mahomes P. Mahomes	46	478	11/19/2018	KC	@	LAR	33	71.7	10.4	6	3	117.6	13.0	6.5	3	30
15	Patrick Mahomes P. Mahomes	45	276	11/16/2025	KC	@	DEN	29	64.4	6.1	1	1	79.5	2.2	2.2	3	27
16	Patrick Mahomes P. Mahomes	45	348	11/22/2020	KC	@	LV	34	75.6	7.7	2	1	102.8	4.4	2.2	0	0
17	Patrick Mahomes P. Mahomes	45	372	11/8/2020	KC	vs	CAR	30	66.7	8.3	4	0	121.7	8.9	0.0	2	11
18	Patrick Mahomes P. Mahomes	45	304	10/1/2018	KC	@	DEN	28	62.2	6.8	1	0	89.5	2.2	0.0	1	0
19	Patrick Mahomes P. Mahomes	44	291	11/4/2024	KC	vs	TB	34	77.3	6.6	3	0	116.8	6.8	0.0	4	31
20	Patrick Mahomes P. Mahomes	44	235	12/25/2023	KC	vs	LV	27	61.4	5.3	1	1	73.6	2.3	2.3	4	23
21	Patrick Mahomes P. Mahomes	44	270	1/8/2022	KC	@	DEN	27	61.4	6.1	2	0	93.9	4.5	0.0	1	15
22	Patrick Mahomes P. Mahomes	44	260	9/26/2021	KC	vs	LAC	27	61.4	5.9	3	2	81.6	6.8	4.5	2	9
23	Patrick Mahomes P. Mahomes	44	278	12/27/2020	KC	vs	ATL	24	54.5	6.3	2	1	79.5	4.5	2.3	0	0
24	Patrick Mahomes P. Mahomes	44	443	9/15/2019	KC	@	OAK	30	68.2	10.1	4	0	131.2	9.1	0.0	2	7
25	Patrick Mahomes P. Mahomes	43	271	12/10/2023	KC	vs	BUF	25	58.1	6.3	1	1	74.9	2.3	2.3	1	7

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Results may be incomplete. StatMuse has complete game-level data for passing attempts and passing yards going back to the 1950 season.

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AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
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Jets - e	3	14	0	.176
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Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
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Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
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Vikings - e	9	8	0	.529
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Buccaneers - e	8	9	0	.471
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Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
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Cardinals - e	3	14	0	.176

Patrick Mahomes made his most passing attempts in a game versus the Titans on November 6, 2022, with 68 attempts.

Interpreted as:

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