Peyton Manning had a passer rating of 81.4 with 2,518 yards, 13 touchdowns and 12 interceptions in 12 games against the Bills in his career.
- Regular season
| NAME | DATE | TM | OPP | CMP | ATT | PCT | YDS | AVG | TD | INT | RTG | TD% | INT% | SCK | SCKY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | P. Manning | 10/11/1998 | vs | 20 | 41 | 48.8 | 235 | 5.7 | 2 | 2 | 62.6 | 4.9 | 4.9 | 0 | 0 | ||
| 2 | | P. Manning | 11/22/1998 | @ | 14 | 29 | 48.3 | 164 | 5.7 | 1 | 2 | 48.6 | 3.4 | 6.9 | 0 | 0 | ||
| 3 | | P. Manning | 9/12/1999 | vs | 21 | 33 | 63.6 | 284 | 8.6 | 2 | 2 | 85.9 | 6.1 | 6.1 | 0 | 0 | ||
| 4 | | P. Manning | 1/2/2000 | @ | 18 | 29 | 62.1 | 163 | 5.6 | 0 | 0 | 77.2 | 0.0 | 0.0 | 0 | 0 | ||
| 5 | | P. Manning | 10/1/2000 | @ | 16 | 27 | 59.3 | 187 | 6.9 | 2 | 1 | 89.6 | 7.4 | 3.7 | 1 | 3 | ||
| 6 | | P. Manning | 12/11/2000 | vs | 13 | 24 | 54.2 | 132 | 5.5 | 0 | 0 | 70.1 | 0.0 | 0.0 | 2 | 16 | ||
| 7 | | P. Manning | 9/23/2001 | vs | 23 | 29 | 79.3 | 421 | 14.5 | 4 | 2 | 129.6 | 13.8 | 6.9 | 1 | 3 | ||
| 8 | | P. Manning | 11/4/2001 | @ | 17 | 27 | 63.0 | 199 | 7.4 | 1 | 0 | 97.6 | 3.7 | 0.0 | 4 | 38 | ||
| 9 | | P. Manning | 11/23/2003 | @ | 26 | 42 | 61.9 | 229 | 5.5 | 0 | 0 | 76.4 | 0.0 | 0.0 | 1 | 6 | ||
| 10 | | P. Manning | 11/12/2006 | vs | 27 | 39 | 69.2 | 236 | 6.1 | 1 | 0 | 93.5 | 2.6 | 0.0 | 0 | 0 | ||
| 11 | | P. Manning | 1/3/2010 | @ | 14 | 18 | 77.8 | 95 | 5.3 | 0 | 1 | 65.5 | 0.0 | 5.6 | 0 | 0 | ||
| 12 |  | P. Manning | 12/7/2014 | vs | 14 | 20 | 70.0 | 173 | 8.7 | 0 | 2 | 56.9 | 0.0 | 10.0 | 0 | 0 | ||
| Average | 18.6 | 29.8 | 62.3 | 209.8 | 7.0 | 1.1 | 1.0 | 81.4 | 3.6 | 3.4 | 0.8 | 5.5 | ||||||
| Total | 223 | 358 | 62.3 | 2,518 | 7.0 | 13 | 12 | 81.4 | 3.6 | 3.4 | 9 | 66 |
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More Colts Stats
Team Leaders 
PASS
166
Jones
RUSH
98
Taylor
REC
61
Pierce
Team Rankings
PPG
23.0
18th
OPP PPG
41.0
31st
RUSH YDS/G
102.0
20th
PASS YDS/G
166.0
26th
Jaguars
Titans
Texans
KC
WAS
PIT
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| NFC North | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
| NFC South | W | L | T | PCT |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| NFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 |
Giants
Eagles
Cowboys
Vikings
Bears
Lions
Packers
Falcons
Buccaneers
Saints
Panthers
49ers
Cardinals
Seahawks
Rams| AFC East | W | L | T | PCT |
|---|---|---|---|---|
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| AFC North | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
| AFC South | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| AFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 |
Jets
Patriots
Dolphins
Ravens
Bengals
Browns
Raiders
Chargers