James Cook III rushed for the most yards by a running back against the Panthers in 2025, with 216 yards.
Interpreted as:
rb most rushing yards stats vs panthers this year| NAME | RUSH YDS | SEASON | TM | GP | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 216 | 2025 | 1 | 19 | 11.4 | 216.0 | 2 | 0 | 0 | 0 | 0.0 | 0 | ||
| 2 |  | B. Robinson | 176 | 2025 | 2 | 36 | 4.9 | 88.0 | 2 | 78 | 9 | 11 | 8.7 | 39.0 | 0 | |
| 3 |  | B. Irving | 156 | 2025 | 2 | 45 | 3.5 | 78.0 | 0 | 13 | 1 | 2 | 13.0 | 6.5 | 0 | |
| 4 |  | T. Etienne Jr. | 143 | 2025 | 1 | 16 | 8.9 | 143.0 | 0 | 13 | 3 | 3 | 4.3 | 13.0 | 0 | |
| 5 |  | Z. Charbonnet | 110 | 2025 | 1 | 18 | 6.1 | 110.0 | 2 | 12 | 2 | 2 | 6.0 | 12.0 | 0 | |
| 6 |  | C. McCaffrey | 89 | 2025 | 1 | 24 | 3.7 | 89.0 | 1 | 53 | 7 | 7 | 7.6 | 53.0 | 0 | |
| 7 |  | J. Jacobs | 87 | 2025 | 1 | 17 | 5.1 | 87.0 | 1 | 13 | 4 | 5 | 3.3 | 13.0 | 0 | |
| 8 |  | A. Kamara | 83 | 2025 | 1 | 22 | 3.8 | 83.0 | 0 | 32 | 3 | 3 | 10.7 | 32.0 | 0 | |
| 9 |  | B. Corum | 81 | 2025 | 1 | 7 | 11.6 | 81.0 | 1 | 0 | 0 | 0 | 0.0 | 0 | ||
| 10 |  | K. Williams | 72 | 2025 | 1 | 13 | 5.5 | 72.0 | 1 | 0 | 0 | 1 | 0.0 | 0 | ||
| 11 |  | R. White | 68 | 2025 | 2 | 12 | 5.7 | 34.0 | 0 | 33 | 4 | 4 | 8.3 | 16.5 | 0 | |
| 12 |  | K. Walker III | 51 | 2025 | 1 | 15 | 3.4 | 51.0 | 0 | 6 | 2 | 2 | 3.0 | 6.0 | 0 | |
| 13 | | D. Neal | 50 | 2025 | 2 | 11 | 4.5 | 25.0 | 1 | 13 | 4 | 4 | 3.3 | 6.5 | 0 | |
| 14 | | N. Carter | 46 | 2025 | 2 | 7 | 6.6 | 23.0 | 0 | 0 | 0 | 0 | 0.0 | 0 | ||
| 15 |  | B. Robinson | 40 | 2025 | 1 | 7 | 5.7 | 40.0 | 0 | 4 | 1 | 2 | 4.0 | 4.0 | 0 | |
| 16 |  | B. Hall | 38 | 2025 | 1 | 11 | 3.5 | 38.0 | 0 | 14 | 2 | 3 | 7.0 | 14.0 | 0 | |
| 17 |  | R. Stevenson | 38 | 2025 | 1 | 9 | 4.2 | 38.0 | 0 | 3 | 1 | 1 | 3.0 | 3.0 | 0 | |
| 18 |  | J. Conner | 34 | 2025 | 1 | 11 | 3.1 | 34.0 | 1 | 18 | 1 | 1 | 18.0 | 18.0 | 0 | |
| 19 |  | T. Henderson | 32 | 2025 | 1 | 7 | 4.6 | 32.0 | 1 | 14 | 2 | 2 | 7.0 | 14.0 | 0 | |
| 20 |  | J. Williams | 29 | 2025 | 1 | 13 | 2.2 | 29.0 | 0 | 5 | 5 | 8 | 1.0 | 5.0 | 0 | |
| 21 |  | A. Gibson | 27 | 2025 | 1 | 6 | 4.5 | 27.0 | 1 | 0 | 0 | 0 | 0.0 | 0 | ||
| 22 | | E. Wilson | 16 | 2025 | 1 | 6 | 2.7 | 16.0 | 0 | 1 | 1 | 2 | 1.0 | 1.0 | 0 | |
| 23 | | R. Davis | 16 | 2025 | 1 | 9 | 1.8 | 16.0 | 0 | 0 | 0 | 1 | 0.0 | 0 | ||
| 24 |  | D. Achane | 16 | 2025 | 1 | 10 | 1.6 | 16.0 | 0 | 30 | 6 | 7 | 5.0 | 30.0 | 1 | |
| 25 |  | T. Allgeier | 14 | 2025 | 2 | 4 | 3.5 | 7.0 | 1 | 6 | 3 | 4 | 2.0 | 3.0 | 0 | |
StatMuse has game-level data for rushing yards going back to the 1960 season.
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |