Alvin Kamara got the most total touchdowns by a running back in a game in 2020, with 6 touchdowns against the Vikings on December 25.

running back with the most touchdowns in a single game this season
Interpreted as:
running back with the most touchdowns in a single regular-season game this season
12/25/2020Kamara11/1/2020Cook11/29/2020Henry11/26/2020Gibson11/15/2020Kamara10/25/2020Wilson10/4/2020Mixon9/27/2020Burkhead9/20/2020Jones9/13/2020Jacobs1/3/2021Dobbins1/3/2021Mattison1/3/2021Williams1/3/2021Thompson1/3/2021Taylor1/3/2021Wilson1/3/2021Henry1/3/2021Jacobs12/27/2020Johnson12/27/2020Perine12/27/2020Taylor12/27/2020Dillon6433333333222222222222

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