The San Francisco 49ers have been beaten twice in Week 2 when winning 2+ games from 2017 through 2026.
| TEAM | DATE | L | W | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/17/2017 | 1 | 0 | @ | L 9-12 | 0 | 11 | 248 | 312 | 16.7 | |||
| 2 | | 49ers | 9/16/2018 | 0 | 1 | vs | W 30-27 | 3 | 23 | 346 | 427 | 27.3 | |||
| 3 | | 49ers | 9/15/2019 | 0 | 1 | @ | W 41-17 | 5 | 27 | 571 | 316 | 55.6 | |||
| 4 | | 49ers | 9/20/2020 | 0 | 1 | @ | W 31-13 | 4 | 17 | 359 | 277 | 53.8 | |||
| 5 | | 49ers | 9/19/2021 | 0 | 1 | @ | W 17-11 | 2 | 23 | 306 | 328 | 42.9 | 100.0 | ||
| 6 | | 49ers | 9/18/2022 | 0 | 1 | vs | W 27-7 | 3 | 25 | 373 | 216 | 40.0 | 66.7 | ||
| 7 | | 49ers | 9/17/2023 | 0 | 1 | @ | W 30-23 | 3 | 21 | 365 | 386 | 22.2 | |||
| 8 | | 49ers | 9/15/2024 | 1 | 0 | @ | L 17-23 | 2 | 24 | 396 | 403 | 20.0 | 33.3 | ||
| 9 | | 49ers | 9/14/2025 | 0 | 1 | @ | W 26-21 | 3 | 23 | 344 | 307 | 53.3 | |||
| 10 | | 49ers | 9/20/2026 | 0 | 1 | vs | W 35-13 | 5 | 23 | 382 | 284 | 71.4 | |||
| Average | 0.2 | 0.8 | 3.0 | 21.7 | 369.0 | 325.6 | 40.0 | 0.2 | |||||||
| Total | 2 | 8 | 30 | 217 | 3,690 | 3,256 | 40.0 | 57.1 |
SF
SEA
DET
CIN
NYJ
PHI
LAR
MIN
NO
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More 49ers Stats
Team Leaders 
PASS
492
Purdy
RUSH
91
McCaffrey
REC
103
Evans
Team Rankings
PPG
31.0
4th
OPP PPG
10.0
3rd
RUSH YDS/G
134.5
8th
PASS YDS/G
246.0
10th
Cardinals
DEN
WAS
ATL
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
2 | 0 | 0 | 1.000 | |
1 | 1 | 0 | .500 | |
1 | 1 | 0 | .500 | |
0 | 2 | 0 | .000 | |
| NFC North | W | L | T | PCT |
2 | 0 | 0 | 1.000 | |
1 | 1 | 0 | .500 | |
1 | 1 | 0 | .500 | |
1 | 1 | 0 | .500 | |
| NFC South | W | L | T | PCT |
1 | 1 | 0 | .500 | |
1 | 1 | 0 | .500 | |
0 | 2 | 0 | .000 | |
0 | 2 | 0 | .000 | |
| NFC West | W | L | T | PCT |
2 | 0 | 0 | 1.000 | |
2 | 0 | 0 | 1.000 | |
1 | 1 | 0 | .500 | |
1 | 1 | 0 | .500 |
Giants
Cowboys
Bears
Packers
Panthers
Buccaneers| AFC East | W | L | T | PCT |
|---|---|---|---|---|
2 | 0 | 0 | 1.000 | |
1 | 1 | 0 | .500 | |
1 | 1 | 0 | .500 | |
0 | 2 | 0 | .000 | |
| AFC North | W | L | T | PCT |
2 | 0 | 0 | 1.000 | |
1 | 1 | 0 | .500 | |
1 | 1 | 0 | .500 | |
1 | 1 | 0 | .500 | |
| AFC South | W | L | T | PCT |
1 | 1 | 0 | .500 | |
0 | 2 | 0 | .000 | |
0 | 2 | 0 | .000 | |
0 | 2 | 0 | .000 | |
| AFC West | W | L | T | PCT |
2 | 0 | 0 | 1.000 | |
2 | 0 | 0 | 1.000 | |
1 | 1 | 0 | .500 | |
0 | 2 | 0 | .000 |
Bills
Patriots
Jets
Ravens
Steelers
Browns
Jaguars
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