The San Francisco 49ers have a 14-16 record against the AFC in the regular-season and playoffs since January 26, 2020.
| TEAM | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 2/2/2020 | @ | L 20-31 | 2 | 21 | 351 | 397 | 37.5 | 0.0 | ||
| 2 | | 49ers | 9/20/2020 | @ | W 31-13 | 4 | 17 | 359 | 277 | 53.8 | |||
| 3 | | 49ers | 10/11/2020 | vs | L 17-43 | 2 | 19 | 259 | 436 | 20.0 | 0.0 | ||
| 4 | | 49ers | 10/25/2020 | @ | W 33-6 | 4 | 26 | 467 | 241 | 55.6 | |||
| 5 | | 49ers | 12/7/2020 | vs | L 24-34 | 3 | 24 | 402 | 449 | 54.5 | 0.0 | ||
| 6 | | 49ers | 10/24/2021 | vs | L 18-30 | 2 | 13 | 280 | 295 | 9.1 | |||
| 7 | | 49ers | 11/21/2021 | @ | W 30-10 | 3 | 25 | 333 | 200 | 50.0 | 100.0 | ||
| 8 | | 49ers | 12/12/2021 | @ | W 26-23 | 3 | 21 | 355 | 397 | 33.3 | |||
| 9 | | 49ers | 12/23/2021 | @ | L 17-20 | 2 | 22 | 389 | 278 | 37.5 | 50.0 | ||
| 10 | | 49ers | 1/2/2022 | vs | W 23-7 | 2 | 19 | 416 | 222 | 38.5 | 0.0 | ||
| 11 | | 49ers | 9/25/2022 | @ | L 10-11 | 1 | 13 | 267 | 261 | 10.0 | |||
| 12 | | 49ers | 10/23/2022 | vs | L 23-44 | 2 | 25 | 444 | 529 | 57.1 | |||
| 13 | | 49ers | 11/13/2022 | vs | W 22-16 | 2 | 22 | 387 | 238 | 52.9 | 100.0 | ||
| 14 | | 49ers | 12/4/2022 | vs | W 33-17 | 3 | 24 | 351 | 308 | 42.1 | 50.0 | ||
| 15 | | 49ers | 1/1/2023 | @ | W 37-34 | 4 | 27 | 454 | 500 | 50.0 | |||
| 16 | | 49ers | 9/10/2023 | @ | W 30-7 | 3 | 22 | 391 | 239 | 46.2 | 100.0 | ||
| 17 | | 49ers | 10/15/2023 | @ | L 17-19 | 2 | 15 | 215 | 334 | 25.0 | |||
| 18 | | 49ers | 10/29/2023 | vs | L 17-31 | 2 | 24 | 460 | 400 | 55.6 | |||
| 19 | | 49ers | 11/12/2023 | @ | W 34-3 | 4 | 20 | 437 | 221 | 33.3 | 50.0 | ||
| 20 | | 49ers | 12/25/2023 | vs | L 19-33 | 2 | 21 | 429 | 343 | 42.9 | 33.3 | ||
| 21 | | 49ers | 2/11/2024 | @ | L 22-25 | 2 | 23 | 382 | 455 | 25.0 | 100.0 | ||
| 22 | | 49ers | 9/9/2024 | vs | W 32-19 | 2 | 24 | 401 | 266 | 46.2 | |||
| 23 | | 49ers | 9/29/2024 | vs | W 30-13 | 3 | 19 | 431 | 216 | 53.8 | |||
| 24 | | 49ers | 10/20/2024 | vs | L 18-28 | 2 | 19 | 310 | 329 | 18.2 | 100.0 | ||
| 25 | | 49ers | 12/1/2024 | @ | L 10-35 | 1 | 15 | 239 | 372 | 30.0 | 100.0 | ||
| Average | 2.5 | 20.7 | 362.6 | 331.4 | 42.3 | 2.4 | |||||||
| Total | 75 | 621 | 10,877 | 9,943 | 42.3 | 44.0 | |||||||
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PASS
2,151
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922
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820
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PPG
24.6
11th
OPP PPG
20.9
11th
RUSH YDS/G
101.4
25th
PASS YDS/G
256.6
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
11 | 3 | 0 | .786 | |
10 | 4 | 0 | .714 | |
 Dolphins - e | 6 | 8 | 0 | .429 |
 Jets - e | 3 | 11 | 0 | .214 |
| AFC North | W | L | T | PCT |
8 | 6 | 0 | .571 | |
7 | 7 | 0 | .500 | |
 Bengals - e | 4 | 10 | 0 | .286 |
 Browns - e | 3 | 11 | 0 | .214 |
| AFC South | W | L | T | PCT |
10 | 4 | 0 | .714 | |
9 | 5 | 0 | .643 | |
8 | 6 | 0 | .571 | |
 Titans - e | 2 | 12 | 0 | .143 |
| AFC West | W | L | T | PCT |
 Broncos - x | 12 | 2 | 0 | .857 |
10 | 4 | 0 | .714 | |
 Chiefs - e | 6 | 8 | 0 | .429 |
 Raiders - e | 2 | 12 | 0 | .143 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
9 | 5 | 0 | .643 | |
6 | 7 | 1 | .464 | |
 Commanders - e | 4 | 10 | 0 | .286 |
 Giants - e | 2 | 12 | 0 | .143 |
| NFC North | W | L | T | PCT |
10 | 4 | 0 | .714 | |
9 | 4 | 1 | .679 | |
8 | 6 | 0 | .571 | |
 Vikings - e | 6 | 8 | 0 | .429 |
| NFC South | W | L | T | PCT |
7 | 7 | 0 | .500 | |
7 | 7 | 0 | .500 | |
 Falcons - e | 5 | 9 | 0 | .357 |
 Saints - e | 4 | 10 | 0 | .286 |
| NFC West | W | L | T | PCT |
 Rams - x | 11 | 3 | 0 | .786 |
11 | 3 | 0 | .786 | |
10 | 4 | 0 | .714 | |
 Cardinals - e | 3 | 11 | 0 | .214 |
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