The Arizona Cardinals had their lowest point differential in a game versus the Seahawks on December 9, 2012, with a -58-point differential.

Interpreted as:

What is the cardinals biggest loss in a regular-season game ever?

	TEAM	DIFF	DATE	TM		OPP	RESULT	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1	Cardinals	-58	12/9/2012	ARI	@	SEA	L 0-58	0	10	154	493	28.6	0.0
2	Cardinals	-49	12/1/2002	ARI	@	KC	L 0-49	0	10	122	477	31.3	0.0
3	Cardinals	-46	10/12/1941	CHC	@	CHB	L 7-53	1	11
4	Cardinals	-43	12/7/1969	STL	@	NYG	L 6-49	0	10	181	517
5	Cardinals	-42	11/8/1981	STL	vs	PHI	L 10-52	1	13	239	452
6	Cardinals	-42	12/3/1944	C-P	vs	CHB	L 7-49	1	10
7	Cardinals	-41	10/22/2000	ARI	@	DAL	L 7-48	1	15	276	347	20.0	0.0
8	Cardinals	-41	11/24/1977	STL	vs	MIA	L 14-55	2	13	210	503
9	Cardinals	-41	11/26/1939	CHC	vs	CHB	L 7-48
10	Cardinals	-40	12/21/2008	ARI	@	NE	L 7-47	1	8	186	514	23.1	0.0
11	Cardinals	-39	10/25/1953	CHC	vs	PHI	L 17-56	2	12	195	542
12	Cardinals	-39	9/28/1936	CHC	@	DET	L 0-39
13	Cardinals	-38	11/16/2003	ARI	@	CLE	L 6-44	0	10	187	481	30.0
14	Cardinals	-38	9/14/2003	ARI	vs	SEA	L 0-38	0	18	286	323	55.6	0.0
15	Cardinals	-38	11/29/1992	PHX	@	WAS	L 3-41	0	14	308	334	27.3	100.0
16	Cardinals	-38	11/6/1983	STL	@	WAS	L 7-45	1	15	267	374
17	Cardinals	-38	12/20/1981	STL	@	PHI	L 0-38	0	11	211	444
18	Cardinals	-38	11/21/1953	CHC	@	PHI	L 0-38	0	10	111	491
19	Cardinals	-38	9/24/1950	CHC	vs	PHI	L 7-45	1	12	265	439
20	Cardinals	-37	12/16/1989	PHX	vs	DEN	L 0-37	0	7	101	475
21	Cardinals	-37	12/4/1988	PHX	@	NYG	L 7-44	1	7	158	301
22	Cardinals	-37	10/15/1939	CHC	@	CHB	L 7-44
23	Cardinals	-36	12/7/2003	ARI	@	SF	L 14-50	2	18	210	496	21.4	66.7
24	Cardinals	-36	12/16/1979	STL	@	CHI	L 6-42	1	11	113	456
25	Cardinals	-35	11/25/2018	ARI	@	LAC	L 10-45	1	10	149	414	33.3	0.0

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More Cardinals Stats

Team Leaders

PASS

542

Murray

RUSH

125

Benson

REC

182

McBride

Team Rankings

PPG

20.7

19th

OPP PPG

17.0

5th

RUSH YDS/G

111.3

16th

PASS YDS/G

180.7

27th

2025 Division Standings

TEAM	W	L	PCT
49ers	3	0	1.000
Cardinals	2	1	.667
Rams	2	1	.667
Seahawks	2	1	.667

Schedule

DATE	MATCHUP			TIME (ET)
Thu 9/25	SEA	@	ARI	8:15 PM
Sun 10/5	TEN	@	ARI	4:05 PM
Sun 10/12	ARI	@	IND	1:00 PM
Sun 10/19	GB	@	ARI	4:25 PM
Mon 11/3	ARI	@	DAL	8:15 PM

Last Game

49ers

3 - 0 - 0

Final

Cardinals

2 - 1 - 0

Sun 21 Sep 2025

NFL 2025 Leaders

Pass Yards Leaders

860

Herbert

831

Smith

816

Jones

Rush Yards Leaders

338

Taylor

284

Cook

270

Etienne

Rec Yards Leaders

333

Nacua

323

Smith-Njigba

281

Pearsall

Pass TD Leaders

9

Jackson

7

Williams

7

Goff

Rush TD Leaders

4

Cook

4

Hurts

3

Gibbs

Rec TD Leaders

4

Odunze

4

St. Brown

4

Tucker

QB Rating Leaders

141.8

Jackson

120.2

Goff

111.7

Jones

Sack Leaders

4.5

Gary

4.0

Garrett

4.0

Young

NFL 2025 Rankings

PPG Rankings

37.0

34.3

34.0

29.3

27.0

Opp PPG Rankings

14.7

15.7

16.3

16.7

17.0

Total Yards Rankings

420.0

418.7

394.3

393.7

363.7

362.3

Rush Yards Rankings

163.0

157.3

153.3

149.0

141.7

139.3

Pass Yards Rankings

286.7

280.3

280.0

277.0

272.0

262.3

Sack Leaders

12.0

11.0

10.0

9.0

NFL Fantasy 2025

Fantasy RB Rankings

67.1

Taylor

59.5

Cook

46.3

Robinson

Fantasy WR Rankings

48.4

St. Brown

46.7

Odunze

46.2

Tucker

Fantasy TE Rankings

29.2

Kraft

28.5

Henry

27.1

Kincaid

Fantasy K Rankings

45

Shrader

43

Slye

41

Aubrey

NFL 2025 Betting

Best Record ATS

3-0

2-1

Worst Record ATS

1-2

NFL 2025 Division Standings

NFC East	W	L	T	PCT
Eagles	3	0	0	1.000
Commanders	2	1	0	.667
NFC North	W	L	T	PCT
Packers	2	1	0	.667
Vikings	2	1	0	.667
NFC South	W	L	T	PCT
Buccaneers	3	0	0	1.000
Panthers	1	2	0	.333
NFC West	W	L	T	PCT
49ers	3	0	0	1.000
Rams	2	1	0	.667

AFC East	W	L	T	PCT
Bills	3	0	0	1.000
Patriots	1	2	0	.333
AFC North	W	L	T	PCT
Bengals	2	1	0	.667
Steelers	2	1	0	.667
AFC South	W	L	T	PCT
Colts	3	0	0	1.000
Jaguars	2	1	0	.667
AFC West	W	L	T	PCT
Chargers	3	0	0	1.000
Raiders	1	2	0	.333

NFL 2025 Scores & Schedule

Scores

DATE	MATCHUP			SCORE
Wed 9/3	DAL	@	PHI	20-24
Thu 9/4	KC	@	LAC	21-27
Sat 9/6	PIT	@	NYJ	34-32
Sat 9/6	TB	@	ATL	23-20
Sat 9/6	LV	@	NE	20-13

Schedule

DATE	MATCHUP			TIME (ET)
Thu 9/25	SEA	@	ARI	8:15 PM
Sun 9/28	MIN	@	PIT	9:30 AM
Sun 9/28	NO	@	BUF	1:00 PM
Sun 9/28	TEN	@	HOU	1:00 PM
Sun 9/28	CLE	@	DET	1:00 PM

The Arizona Cardinals had their lowest point differential in a game versus the Seahawks on December 9, 2012, with a -58-point differential.

Interpreted as:

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More Cardinals Stats

542

125

182

NFL 2025 Leaders

860

831

816

338

284

270

333

323

281

9

7

7

4

4

3

4

4

4

141.8

120.2

111.7

4.5

4.0

4.0

NFL 2025 Rankings

NFL Fantasy 2025

67.1

59.5

46.3

48.4

46.7

46.2

29.2

28.5

27.1

45

43

41

NFL 2025 Betting

NFL 2025 Division Standings

NFL 2025 Scores & Schedule

Scores

Schedule