Peyton Manning has the most passing touchdowns by a quarterback in a home, Week-1 game, with 7 touchdowns against the Ravens on September 5, 2013.
| NAME | TD | DATE | TM | OPP | CMP | ATT | PCT | YDS | AVG | INT | RTG | TD% | INT% | SCK | SCKY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | P. Manning | 7 | 9/5/2013 |  DEN | vs |  BAL | 27 | 42 | 64.3 | 462 | 11.0 | 0 | 141.1 | 16.7 | 0.0 | 3 | 17 |
| 2 |  | D. Brees | 6 | 9/13/2009 |  NO | vs |  DET | 26 | 34 | 76.5 | 358 | 10.5 | 1 | 137.0 | 17.6 | 2.9 | 0 | 0 |
| 3 |  | J. Winston | 5 | 9/12/2021 | NO | vs |  GB | 14 | 20 | 70.0 | 148 | 7.4 | 0 | 130.8 | 25.0 | 0.0 | 0 | 0 |
| 4 |  | D. Culpepper | 5 | 9/12/2004 |  MIN | vs |  DAL | 17 | 23 | 73.9 | 242 | 10.5 | 0 | 147.1 | 21.7 | 0.0 | 2 | 0 |
| 5 |  | D. Marino | 5 | 9/4/1994 |  MIA | vs |  NE | 23 | 42 | 54.8 | 473 | 11.3 | 1 | 124.3 | 11.9 | 2.4 | 2 | 17 |
| 6 | | S. DeBerg | 5 | 9/13/1987 |  TB | vs |  ATL | 24 | 34 | 70.6 | 333 | 9.8 | 1 | 129.0 | 14.7 | 2.9 | 0 | 0 |
| 7 | | M. Malone | 5 | 9/8/1985 |  PIT | vs |  IND | 21 | 30 | 70.0 | 287 | 9.6 | 1 | 126.0 | 16.7 | 3.3 | 0 | 0 |
| 8 |  | N. Van Brocklin | 5 | 9/28/1951 |  LA | vs |  NYY | 27 | 41 | 65.9 | 554 | 13.5 | 2 | 128.3 | 12.2 | 4.9 | ||
| 9 |  | B. Mayfield | 4 | 9/8/2024 | TB | vs |  WAS | 24 | 30 | 80.0 | 289 | 9.6 | 0 | 146.4 | 13.3 | 0.0 | 1 | 9 |
| 10 |  | C. Wentz | 4 | 9/11/2022 | WAS | vs |  JAX | 27 | 41 | 65.9 | 313 | 7.6 | 2 | 101.0 | 9.8 | 4.9 | 1 | 8 |
| 11 |  | T. Brady | 4 | 9/9/2021 | TB | vs | DAL | 32 | 50 | 64.0 | 379 | 7.6 | 2 | 97.0 | 8.0 | 4.0 | 0 | 0 |
| 12 |  | D. Prescott | 4 | 9/8/2019 | DAL | vs |  NYG | 25 | 32 | 78.1 | 405 | 12.7 | 0 | 158.3 | 12.5 | 0.0 | 0 | 0 |
| 13 |  | M. Stafford | 4 | 9/10/2017 | DET | vs |  ARI | 29 | 41 | 70.7 | 292 | 7.1 | 1 | 113.1 | 9.8 | 2.4 | 1 | 7 |
| 14 | | D. Brees | 4 | 9/11/2016 | NO | vs |  OAK | 28 | 42 | 66.7 | 423 | 10.1 | 0 | 131.3 | 9.5 | 0.0 | 1 | 4 |
| 15 |  | A. Luck | 4 | 9/11/2016 | IND | vs | DET | 31 | 47 | 66.0 | 385 | 8.2 | 0 | 119.5 | 8.5 | 0.0 | 2 | 17 |
| 16 |  | T. Brady | 4 | 9/10/2015 | NE | vs | PIT | 25 | 32 | 78.1 | 288 | 9.0 | 0 | 143.8 | 12.5 | 0.0 | 2 | 7 |
| 17 |  | P. Rivers | 4 | 9/9/2013 |  SD | vs |  HOU | 14 | 29 | 48.3 | 195 | 6.7 | 1 | 95.5 | 13.8 | 3.4 | 2 | 12 |
| 18 |  | T. Romo | 4 | 9/9/2007 | DAL | vs | NYG | 15 | 24 | 62.5 | 345 | 14.4 | 1 | 128.5 | 16.7 | 4.2 | 1 | 9 |
| 19 | | D. McNabb | 4 | 9/12/2004 |  PHI | vs | NYG | 26 | 36 | 72.2 | 330 | 9.2 | 0 | 137.5 | 11.1 | 0.0 | 2 | 17 |
| 20 | | J. Harrington | 4 | 9/7/2003 | DET | vs | ARI | 17 | 30 | 56.7 | 195 | 6.5 | 0 | 116.0 | 13.3 | 0.0 | 0 | 0 |
| 21 |  | B. Favre | 4 | 9/12/1999 | GB | vs | OAK | 28 | 47 | 59.6 | 333 | 7.1 | 3 | 83.0 | 8.5 | 6.4 | 3 | 15 |
| 22 | | B. Johnson | 4 | 9/6/1998 | MIN | vs | TB | 15 | 25 | 60.0 | 189 | 7.6 | 1 | 106.5 | 16.0 | 4.0 | 1 | 8 |
| 23 | | D. Bledsoe | 4 | 8/31/1997 | NE | vs | SD | 26 | 39 | 66.7 | 340 | 8.7 | 0 | 128.2 | 10.3 | 0.0 | 0 | 0 |
| 24 |  | S. Young | 4 | 9/5/1994 |  SF | vs | RAI | 19 | 32 | 59.4 | 308 | 9.6 | 1 | 118.2 | 12.5 | 3.1 | 2 | 16 |
| 25 |  | J. Kelly | 4 | 9/5/1993 |  BUF | vs | NE | 13 | 22 | 59.1 | 167 | 7.6 | 1 | 103.6 | 18.2 | 4.5 | 1 | 10 |
Results may be incomplete. StatMuse has complete game-level data for passing touchdowns going back to the 1950 season.
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18.3
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112.2
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224.0
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
| Eagles | 14 | 3 | 0 | .824 |
| Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
| Lions | 15 | 2 | 0 | .882 |
| Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
| Buccaneers | 10 | 7 | 0 | .588 |
| Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
 Rams | 10 | 7 | 0 | .588 |
 Seahawks | 10 | 7 | 0 | .588 |
