The San Francisco 49ers had their highest point differential in a game versus the Lions on October 1, 1961, with a 49-point differential.
Interpreted as:
What was the highest win margin in a regular-season game for the 49ers ever?| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 49 | 10/1/1961 | @ | W 49-0 | 7 | 23 | 317 | 291 | ||||
| 2 | | 49ers | 48 | 12/27/1987 | vs | W 48-0 | 7 | 23 | 427 | 145 | ||||
| 3 | | 49ers | 45 | 10/9/2011 | vs | W 48-3 | 6 | 28 | 418 | 272 | 28.6 | 100.0 | ||
| 4 | | 49ers | 44 | 12/8/1984 | vs | W 51-7 | 6 | 29 | 521 | 265 | ||||
| 5 | | 49ers | 42 | 10/7/2012 | vs | W 45-3 | 6 | 29 | 621 | 204 | 63.6 | 100.0 | ||
| 6 | | 49ers | 42 | 9/7/2003 | vs | W 49-7 | 5 | 23 | 391 | 127 | 50.0 | 0.0 | ||
| 7 | | 49ers | 42 | 11/12/1989 | vs | W 45-3 | 6 | 30 | 515 | 192 | ||||
| 8 | | 49ers | 41 | 12/14/1987 | vs | W 41-0 | 5 | 20 | 331 | 263 | ||||
| 9 | | 49ers | 40 | 10/21/1973 | vs | W 40-0 | 5 | 21 | 424 | 82 | ||||
| 10 | | 49ers | 39 | 10/16/1994 | @ | W 42-3 | 6 | 16 | 281 | 254 | 46.2 | 60.0 | ||
| 11 | | 49ers | 39 | 10/18/1992 | vs | W 56-17 | 8 | 29 | 590 | 297 | 60.0 | |||
| 12 | | 49ers | 38 | 10/27/2019 | vs | W 51-13 | 7 | 24 | 388 | 230 | 50.0 | |||
| 13 | | 49ers | 38 | 1/6/2002 | @ | W 38-0 | 5 | 22 | 407 | 126 | 35.7 | 50.0 | ||
| 14 | | 49ers | 38 | 12/19/1993 | @ | W 55-17 | 7 | 26 | 565 | 288 | 71.4 | 100.0 | ||
| 15 | | 49ers | 38 | 11/9/1992 | @ | W 41-3 | 5 | 16 | 303 | 304 | 50.0 | |||
| 16 | | 49ers | 38 | 12/23/1991 | vs | W 52-14 | 7 | 30 | 486 | 404 | 37.5 | |||
| 17 | | 49ers | 38 | 11/27/1988 | @ | W 48-10 | 6 | 24 | 475 | 312 | ||||
| 18 | | 49ers | 37 | 10/16/1966 | @ | W 44-7 | 6 | 29 | 504 | 215 | ||||
| 19 | | 49ers | 36 | 12/7/2003 | vs | W 50-14 | 7 | 30 | 496 | 210 | 50.0 | 0.0 | ||
| 20 | | 49ers | 36 | 12/4/1994 | vs | W 50-14 | 6 | 28 | 476 | 248 | 53.3 | 0.0 | ||
| 21 | | 49ers | 35 | 10/4/2009 | vs | W 35-0 | 5 | 13 | 228 | 177 | 30.8 | |||
| 22 | | 49ers | 35 | 12/2/2001 | vs | W 35-0 | 5 | 26 | 409 | 191 | 66.7 | 0.0 | ||
| 23 | | 49ers | 35 | 9/14/1998 | @ | W 45-10 | 6 | 28 | 504 | 322 | 58.3 | |||
| 24 | | 49ers | 35 | 11/22/1993 | vs | W 42-7 | 6 | 25 | 455 | 261 | 61.5 | |||
| 25 | | 49ers | 35 | 10/29/1972 | @ | W 49-14 | 7 | 19 | 348 | 152 | ||||
RAM
CHI
STL
WASMore 49ers Stats
Team Leaders 
PASS
262
Purdy
RUSH
48
McCaffrey
REC
111
Robinson
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
