7 quarterbacks were tied for the highest passer rating by a quarterback in a game in 2000, with a 158.3 rating. The first three are Doug Flutie on December 23, 2000, Neil O'Donnell on December 10, 2000 and Peyton Manning on October 22, 2000.

which quarterback has the highest passer rating in a game in 2000
Interpreted as:
Which quarterback has the highest passer rating in a regular-season game in 2000?
12/23/2000Flutie12/10/2000O'Donnell10/22/2000Manning10/22/2000Moon10/8/2000Bishop10/1/2000Warner9/24/2000McNair10/1/2000Green11/19/2000Culpepper12/10/2000Martin11/5/2000Blake10/29/2000King10/22/2000Chandler10/29/2000Brunell9/24/2000Johnson9/25/2000Manning10/29/2000Aikman12/10/2000Brunell12/10/2000McNabb12/24/2000Gannon9/24/2000Stoerner12/3/2000Fiedler9/10/2000Plummer158.3158.3158.3158.3158.3158.3158.3156.3151.1149.3148.1148.0147.9146.4145.8143.3142.1141.4137.5136.2135.8135.7134.5
NAMEDATETMOPPRATECMPATTPCTYDSAVGTDTD%INTINT%SCKSCKY
Doug FlutieDoug Flutie12/23/2000BUFBUF@ SEA
@
158.3202580.036614.6312.000.000
Neil O'DonnellNeil O'Donnell12/10/2000TENTENvs. CIN
vs.
158.366100.09315.5116.700.000
Peyton ManningPeyton Manning10/22/2000INDINDvs. NE
vs.
158.3162080.026813.4315.000.000
Warren MoonWarren Moon10/22/2000KCKCvs. STL
vs.
158.333100.07826.0133.300.000
Michael BishopMichael Bishop10/8/2000NENEvs. IND
vs.
158.311100.04444.01100.000.000
Kurt WarnerKurt Warner10/1/2000STLSTLvs. SD
vs.
158.3243080.039013.0413.300.0214
Steve McNairSteve McNair9/24/2000TENTEN@ PIT
@
158.333100.05518.3133.300.000
Trent GreenTrent Green10/1/2000STLSTLvs. SD
vs.
156.33475.07518.8125.000.000
Daunte CulpepperDaunte Culpepper11/19/2000MINMINvs. CAR
vs.
151.1222975.935712.3310.300.0128
Jamie MartinJamie Martin12/10/2000JAXJAXvs. ARI
vs.
149.32366.77324.3133.300.000
Jeff BlakeJeff Blake11/5/2000NONOvs. SF
vs.
148.1212777.828810.7311.100.0439
Shaun KingShaun King10/29/2000TBTBvs. MIN
vs.
148.0162369.626711.6417.400.016
Chris ChandlerChris Chandler10/22/2000ATLATLvs. NO
vs.
147.9152075.024012.0210.000.0637
Mark BrunellMark Brunell10/29/2000JAXJAX@ DAL
@
146.4202483.32319.6312.500.000
Brad JohnsonBrad Johnson9/24/2000WASWAS@ NYG
@
145.8142070.028914.5210.000.015
Peyton ManningPeyton Manning9/25/2000INDINDvs. JAX
vs.
143.3233663.944012.2411.100.000
Troy AikmanTroy Aikman10/29/2000DALDALvs. JAX
vs.
142.14580.0438.6120.000.000
Mark BrunellMark Brunell12/10/2000JAXJAXvs. ARI
vs.
141.4131872.218210.1211.100.000
Donovan McNabbDonovan McNabb12/10/2000PHIPHI@ CLE
@
137.5233663.939010.8411.100.0540
Rich GannonRich Gannon12/24/2000OAKOAKvs. CAR
vs.
136.2263281.32307.2515.600.000
Clint StoernerClint Stoerner9/24/2000DALDALvs. SF
vs.
135.83560.05310.6120.000.0221
Jay FiedlerJay Fiedler12/3/2000MIAMIA@ BUF
@
135.7132161.921410.2314.300.0214
Jake PlummerJake Plummer9/10/2000ARIARIvs. DAL
vs.
134.5182475.024310.128.300.0219
Troy AikmanTroy Aikman10/22/2000DALDALvs. ARI
vs.
134.491560.015410.3213.300.017
Daunte CulpepperDaunte Culpepper12/24/2000MINMIN@ IND
@
134.271070.0979.7110.000.000

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