Calvin Johnson has gained the most yards from scrimmage by a player as a starter in a game, with 329 yards against the Cowboys on October 27, 2013.
Calvin Johnson has gained the most yards from scrimmage by a player as a starter in a game, with 329 yards against the Cowboys on October 27, 2013.
| NAME | DATE | TM | OPP | YDS | RUSH YDS | ATT | RUSH AVG | RUSH TD | REC YDS | REC | TRG | REC AVG | REC TD | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Calvin Johnson | 10/27/2013 |  DET |  vs. | 329 | 0 | 0 | 0 | 329 | 14 | 17 | 23.5 | 1 | |
 | Adrian Peterson | 11/4/2007 |  MIN |  vs. | 315 | 296 | 30 | 9.9 | 3 | 19 | 1 | 2 | 19.0 | 0 |
| Priest Holmes | 11/24/2002 |  KC |  @ | 307 | 197 | 23 | 8.6 | 2 | 110 | 7 | 7 | 15.7 | 1 |
 | Antonio Brown | 11/8/2015 |  PIT |  vs. | 306 | 22 | 2 | 11.0 | 0 | 284 | 17 | 23 | 16.7 | 0 |
 | Julio Jones | 10/2/2016 |  ATL |  vs. | 300 | 0 | 0 | 0 | 300 | 12 | 15 | 25.0 | 1 | |
 | Jerry Rice | 12/18/1995 |  SF | vs. | 299 | 10 | 1 | 10.0 | 0 | 289 | 14 | 20.6 | 3 | |
 | Le'Veon Bell | 12/11/2016 | PIT |  @ | 298 | 236 | 38 | 6.2 | 3 | 62 | 4 | 5 | 15.5 | 0 |
| Jerome Harrison | 12/20/2009 |  CLE | @ | 298 | 286 | 34 | 8.4 | 3 | 12 | 2 | 3 | 6.0 | 0 |
| Jamal Lewis | 9/14/2003 |  BAL | vs. | 295 | 295 | 30 | 9.8 | 2 | 0 | 0 | 1 | 0 | |
| Jimmy Smith | 9/10/2000 |  JAX | @ | 291 | 0 | 0 | 0 | 291 | 15 | 21 | 19.4 | 3 | |
| Jamaal Charles | 9/23/2012 | KC |  @ | 288 | 233 | 33 | 7.1 | 1 | 55 | 6 | 8 | 9.2 | 0 |
 | Terrell Owens | 12/17/2000 | SF |  vs. | 288 | 5 | 1 | 5.0 | 0 | 283 | 20 | 22 | 14.2 | 1 |
 | Marshall Faulk | 10/15/2000 |  STL | vs. | 286 | 208 | 25 | 8.3 | 1 | 78 | 7 | 10 | 11.1 | 0 |
| Chris Johnson | 9/20/2009 |  TEN |  vs. | 284 | 197 | 16 | 12.3 | 2 | 87 | 9 | 11 | 9.7 | 1 |
 | Saquon Barkley | 12/22/2019 |  NYG |  @ | 279 | 189 | 22 | 8.6 | 1 | 90 | 4 | 4 | 22.5 | 1 |
| Corey Dillon | 10/22/2000 |  CIN |  vs. | 278 | 278 | 22 | 12.6 | 2 | 0 | 0 | 0 | 0 | |
| Priest Holmes | 12/9/2001 | KC | @ | 277 | 168 | 28 | 6.0 | 1 | 109 | 5 | 7 | 21.8 | 1 |
 | Todd Gurley | 12/24/2017 | LAR | @ | 276 | 118 | 22 | 5.4 | 0 | 158 | 10 | 13 | 15.8 | 2 |
| Tiki Barber | 12/28/2002 | NYG |  vs. | 276 | 203 | 32 | 6.3 | 0 | 73 | 8 | 11 | 9.1 | 0 |
| Corey Dillon | 12/4/1997 | CIN | vs. | 276 | 246 | 39 | 6.3 | 4 | 30 | 2 | 15.0 | 0 | |
| Andre Johnson | 11/18/2012 | HOU | vs. | 273 | 0 | 0 | 0 | 273 | 14 | 19 | 19.5 | 1 | |
| Shaun Alexander | 11/11/2001 | SEA | vs. | 273 | 266 | 35 | 7.6 | 3 | 7 | 1 | 1 | 7.0 | 0 |
 | Doug Martin | 11/4/2012 |  TB | @ | 272 | 251 | 25 | 10.0 | 4 | 21 | 4 | 5 | 5.3 | 0 |
 | LaDainian Tomlinson | 12/1/2002 | SD | vs. | 271 | 220 | 37 | 5.9 | 3 | 51 | 11 | 14 | 4.6 | 0 |
 | Tyreek Hill | 11/29/2020 | KC | @ | 269 | 0 | 0 | 0 | 269 | 13 | 15 | 20.7 | 3 |