Calvin Johnson has gained the most yards from scrimmage by a player as a starter in a game, with 329 yards against the Cowboys on October 27, 2013.

who has the highest scrimmage yards with 5 game start
Interpreted as:
Who has the highest scrimmage yards with 5 regular-season game start?
10/27/2013Johnson11/4/2007Peterson11/24/2002Holmes11/8/2015Brown10/2/2016Jones12/18/1995Rice12/11/2016Bell12/20/2009Harrison9/14/2003Lewis9/10/2000Smith9/23/2012Charles12/17/2000Owens10/15/2000Faulk9/20/2009Johnson12/22/2019Barkley10/22/2000Dillon12/9/2001Holmes12/24/2017Gurley12/28/2002Barber12/4/1997Dillon11/18/2012Johnson11/11/2001Alexander11/4/2012Martin329315307306300299298298295291288288286284279278277276276276273273272
NAMEDATETMOPPYDSRUSH YDSATTRUSH AVGRUSH TDREC YDSRECTRGREC AVGREC TD
Calvin JohnsonCalvin Johnson10/27/2013DETDETvs. DAL
vs.
329000329141723.51
Adrian PetersonAdrian Peterson11/4/2007MINMINvs. SD
vs.
315296309.93191219.00
Priest HolmesPriest Holmes11/24/2002KCKC@ SEA
@
307197238.621107715.71
Antonio BrownAntonio Brown11/8/2015PITPITvs. OAK
vs.
30622211.00284172316.70
Julio JonesJulio Jones10/2/2016ATLATLvs. CAR
vs.
300000300121525.01
Jerry RiceJerry Rice12/18/1995SFSFvs. MIN
vs.
29910110.002891420.63
Le'Veon BellLe'Veon Bell12/11/2016PITPIT@ BUF
@
298236386.23624515.50
Jerome HarrisonJerome Harrison12/20/2009CLECLE@ KC
@
298286348.4312236.00
Jamal LewisJamal Lewis9/14/2003BALBALvs. CLE
vs.
295295309.820010
Jimmy SmithJimmy Smith9/10/2000JAXJAX@ BAL
@
291000291152119.43
Jamaal CharlesJamaal Charles9/23/2012KCKC@ NO
@
288233337.1155689.20
Terrell OwensTerrell Owens12/17/2000SFSFvs. CHI
vs.
288515.00283202214.21
Marshall FaulkMarshall Faulk10/15/2000STLSTLvs. ATL
vs.
286208258.317871011.10
Chris JohnsonChris Johnson9/20/2009TENTENvs. HOU
vs.
2841971612.32879119.71
Saquon BarkleySaquon Barkley12/22/2019NYGNYG@ WAS
@
279189228.61904422.51
Corey DillonCorey Dillon10/22/2000CINCINvs. DEN
vs.
2782782212.620000
Priest HolmesPriest Holmes12/9/2001KCKC@ OAK
@
277168286.011095721.81
Todd GurleyTodd Gurley12/24/2017LARLAR@ TEN
@
276118225.40158101315.82
Tiki BarberTiki Barber12/28/2002NYGNYGvs. PHI
vs.
276203326.30738119.10
Corey DillonCorey Dillon12/4/1997CINCINvs. TEN
vs.
276246396.3430215.00
Andre JohnsonAndre Johnson11/18/2012HOUHOUvs. JAX
vs.
273000273141919.51
Shaun AlexanderShaun Alexander11/11/2001SEASEAvs. OAK
vs.
273266357.637117.00
Doug MartinDoug Martin11/4/2012TBTB@ OAK
@
2722512510.0421455.30
LaDainian TomlinsonLaDainian Tomlinson12/1/2002SDSDvs. DEN
vs.
271220375.935111144.60
Tyreek HillTyreek Hill11/29/2020KCKC@ TB
@
269000269131520.73

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