DeAndre Hopkins has been targeted the most times by a wide receiver in a Week-4 game, with 22 targets against the Falcons on October 4, 2015.
| NAME | TRG | DATE | TM | OPP | REC | REC YDS | AVG | REC TD | RUSH YDS | ATT | YPC | RUSH TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Hopkins | 22 | 10/4/2015 |  HOU | @ |  ATL | 9 | 157 | 17.4 | 0 | 0 | 0 | 0 | |
| 2 |  | T. Owens | 20 | 10/2/2005 |  PHI | @ |  KC | 11 | 171 | 15.5 | 1 | 0 | 0 | 0 | |
| 3 |  | C. Kupp | 19 | 10/3/2022 |  LAR | @ |  SF | 14 | 122 | 8.7 | 0 | 0 | 0 | 0 | |
| 4 |  | B. Hartline | 19 | 9/30/2012 |  MIA | @ |  ARI | 12 | 253 | 21.1 | 1 | 0 | 0 | 0 | |
| 5 |  | R. Wayne | 19 | 10/3/2010 |  IND | @ |  JAX | 15 | 196 | 13.1 | 0 | 0 | 0 | 0 | |
| 6 | | B. Lloyd | 18 | 10/3/2010 |  DEN | @ |  TEN | 11 | 115 | 10.5 | 0 | 0 | 0 | 0 | |
| 7 | | T. Glenn | 18 | 10/3/1999 |  NE | @ |  CLE | 13 | 214 | 16.5 | 1 | 0 | 0 | 0 | |
| 8 |  | J. Jones | 17 | 10/2/2011 | ATL | @ |  SEA | 11 | 127 | 11.5 | 0 | 0 | 0 | 0 | |
| 9 |  | T. Owens | 17 | 9/28/2008 |  DAL | vs |  WAS | 7 | 71 | 10.1 | 1 | 11 | 2 | 5.5 | 0 |
| 10 | | P. Burress | 17 | 10/2/2005 |  NYG | vs |  STL | 10 | 204 | 20.4 | 2 | 0 | 0 | 0 | |
| 11 |  | A. Cooper | 16 | 10/4/2020 | DAL | vs | CLE | 12 | 134 | 11.2 | 1 | 0 | 0 | 0 | |
| 12 |  | J. Brown | 16 | 10/2/2016 | ARI | vs | LA | 10 | 144 | 14.4 | 0 | 0 | 0 | 0 | |
| 13 | | V. Cruz | 16 | 9/29/2013 | NYG | @ | KC | 10 | 164 | 16.4 | 1 | 0 | 0 | 0 | |
| 14 | | S. Smith | 16 | 10/4/2009 | NYG | @ | KC | 11 | 134 | 12.2 | 2 | 0 | 0 | 0 | |
| 15 | | R. White | 16 | 9/28/2008 | ATL | @ |  CAR | 7 | 90 | 12.9 | 0 | 0 | 0 | 0 | |
| 16 | | D. Bennett | 16 | 10/3/2004 | TEN | @ |  SD | 9 | 109 | 12.1 | 0 | 0 | 0 | 0 | |
| 17 | | T. Holt | 16 | 9/28/2003 | STL | vs | ARI | 12 | 133 | 11.1 | 1 | 0 | 0 | 0 | |
| 18 | | M. Muhammad | 16 | 10/7/2001 | CAR | @ | SF | 8 | 62 | 7.8 | 0 | 0 | 0 | 0 | |
| 19 |  | N. Collins | 15 | 9/29/2024 | HOU | vs | JAX | 12 | 151 | 12.6 | 1 | 0 | 0 | 0 | |
| 20 |  | M. Nabers | 15 | 9/26/2024 | NYG | vs | DAL | 12 | 115 | 9.6 | 0 | -4 | 1 | -4.0 | 0 |
| 21 |  | R. Woods | 15 | 9/29/2019 |  LAR | vs |  TB | 13 | 164 | 12.6 | 0 | 0 | 0 | 0 | |
| 22 | | C. Kupp | 15 | 9/29/2019 | LAR | vs | TB | 9 | 121 | 13.4 | 1 | -2 | 1 | -2.0 | 0 |
| 23 |  | D. Adams | 15 | 9/26/2019 |  GB | vs | PHI | 10 | 180 | 18.0 | 0 | 0 | 0 | 0 | |
| 24 |  | T. Boyd | 15 | 9/30/2018 |  CIN | @ | ATL | 11 | 100 | 9.1 | 0 | 0 | 0 | 0 | |
| 25 |  | C. Davis | 15 | 9/30/2018 | TEN | vs | PHI | 9 | 161 | 17.9 | 1 | 0 | 0 | 0 | |
StatMuse has game-level data for targets going back to the 1999 season.
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 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
 Lions | 15 | 2 | 0 | .882 |
 Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
| Buccaneers | 10 | 7 | 0 | .588 |
| Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
| Rams | 10 | 7 | 0 | .588 |
| Seahawks | 10 | 7 | 0 | .588 |
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