The San Francisco 49ers have a 54-59 record against the AFC in the regular-season and playoffs on the road all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/15/1970 | 1-0 | @ | W 30-20 | 1.000 | 4 | 17 | 376 | 268 | ||||
| 2 | | 49ers | 12/20/1970 | 1-0 | @ | W 38-7 | 1.000 | 5 | 16 | 296 | 358 | ||||
| 3 | | 49ers | 11/28/1971 | 1-0 | @ | W 24-21 | 1.000 | 3 | 20 | 351 | 393 | ||||
| 4 | | 49ers | 9/24/1972 | 0-1 | @ | L 20-27 | .000 | 2 | 10 | 202 | 233 | ||||
| 5 | | 49ers | 9/16/1973 | 0-1 | @ | L 13-21 | .000 | 1 | 16 | 252 | 279 | ||||
| 6 | | 49ers | 9/23/1973 | 1-0 | @ | W 36-34 | 1.000 | 3 | 16 | 347 | 355 | ||||
| 7 | | 49ers | 12/1/1974 | 0-1 | @ | L 0-7 | .000 | 0 | 14 | 192 | 183 | ||||
| 8 | | 49ers | 10/5/1975 | 1-0 | @ | W 20-3 | 1.000 | 2 | 15 | 215 | 212 | ||||
| 9 | | 49ers | 10/26/1975 | 0-1 | @ | L 16-24 | .000 | 2 | 14 | 243 | 306 | ||||
| 10 | | 49ers | 12/5/1976 | 0-1 | @ | L 7-13 | .000 | 1 | 18 | 281 | 267 | ||||
| 11 | | 49ers | 9/19/1977 | 0-1 | @ | L 0-27 | .000 | 0 | 8 | 101 | 308 | ||||
| 12 | | 49ers | 9/3/1978 | 0-1 | @ | L 7-24 | .000 | 1 | 18 | 295 | 393 | ||||
| 13 | | 49ers | 9/17/1978 | 0-1 | @ | L 19-20 | .000 | 2 | 18 | 382 | 332 | ||||
| 14 | | 49ers | 9/30/1979 | 0-1 | @ | L 9-31 | .000 | 1 | 14 | 242 | 317 | ||||
| 15 | | 49ers | 11/4/1979 | 0-1 | @ | L 10-23 | .000 | 1 | 19 | 363 | 309 | ||||
| 16 | | 49ers | 9/21/1980 | 1-0 | @ | W 37-27 | 1.000 | 5 | 24 | 376 | 460 | ||||
| 17 | | 49ers | 11/16/1980 | 0-1 | @ | L 13-17 | .000 | 2 | 20 | 289 | 378 | ||||
| 18 | | 49ers | 11/1/1981 | 1-0 | @ | W 17-14 | 1.000 | 2 | 25 | 330 | 269 | ||||
| 19 | | 49ers | 12/6/1981 | 1-0 | @ | W 21-3 | 1.000 | 3 | 24 | 325 | 345 | ||||
| 20 | | 49ers | 1/24/1982 | 1-0 | @ | W 26-21 | 1.000 | 2 | 20 | 275 | 356 | ||||
| 21 | | 49ers | 9/19/1982 | 0-1 | @ | L 21-24 | .000 | 3 | 20 | 413 | 283 | ||||
| 22 | | 49ers | 12/26/1982 | 1-0 | @ | W 26-13 | 1.000 | 2 | 23 | 370 | 275 | ||||
| 23 | | 49ers | 10/2/1983 | 1-0 | @ | W 33-13 | 1.000 | 3 | 29 | 426 | 295 | ||||
| 24 | | 49ers | 12/11/1983 | 1-0 | @ | W 23-10 | 1.000 | 2 | 19 | 310 | 303 | ||||
| 25 | | 49ers | 10/21/1984 | 1-0 | @ | W 34-21 | 1.000 | 4 | 25 | 517 | 432 | ||||
| Average | .478 | 2.5 | 19.4 | 338.1 | 327.2 | ||||||||||
| Total | 54-59 | .478 | 277 | 2,188 | 38,206 | 36,977 | |||||||||
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Team Leaders 
PASS
2,151
Jones
RUSH
922
McCaffrey
REC
820
McCaffrey
Team Rankings
PPG
24.6
11th
OPP PPG
20.9
11th
RUSH YDS/G
101.4
25th
PASS YDS/G
256.6
6th
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NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
11 | 3 | 0 | .786 | |
10 | 4 | 0 | .714 | |
 Dolphins - e | 6 | 8 | 0 | .429 |
 Jets - e | 3 | 11 | 0 | .214 |
| AFC North | W | L | T | PCT |
8 | 6 | 0 | .571 | |
7 | 7 | 0 | .500 | |
 Bengals - e | 4 | 10 | 0 | .286 |
 Browns - e | 3 | 11 | 0 | .214 |
| AFC South | W | L | T | PCT |
10 | 4 | 0 | .714 | |
9 | 5 | 0 | .643 | |
8 | 6 | 0 | .571 | |
 Titans - e | 2 | 12 | 0 | .143 |
| AFC West | W | L | T | PCT |
 Broncos - x | 12 | 2 | 0 | .857 |
10 | 4 | 0 | .714 | |
 Chiefs - e | 6 | 8 | 0 | .429 |
 Raiders - e | 2 | 12 | 0 | .143 |
Ravens
Jaguars
Texans| NFC East | W | L | T | PCT |
|---|---|---|---|---|
9 | 5 | 0 | .643 | |
6 | 7 | 1 | .464 | |
 Commanders - e | 4 | 10 | 0 | .286 |
 Giants - e | 2 | 12 | 0 | .143 |
| NFC North | W | L | T | PCT |
10 | 4 | 0 | .714 | |
9 | 4 | 1 | .679 | |
8 | 6 | 0 | .571 | |
 Vikings - e | 6 | 8 | 0 | .429 |
| NFC South | W | L | T | PCT |
7 | 7 | 0 | .500 | |
7 | 7 | 0 | .500 | |
 Falcons - e | 5 | 9 | 0 | .357 |
 Saints - e | 4 | 10 | 0 | .286 |
| NFC West | W | L | T | PCT |
 Rams - x | 11 | 3 | 0 | .786 |
11 | 3 | 0 | .786 | |
10 | 4 | 0 | .714 | |
 Cardinals - e | 3 | 11 | 0 | .214 |
Eagles
Cowboys
Packers
Lions
Buccaneers
Panthers
