The San Francisco 49ers have a 21-18 record against the spread against the NFC West since January 26, 2020.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/13/2020 | 0-1 | -312 | vs | +245 | L 20-24 | -6.5 | -10.5 (N) | 48 | -4 (U) | 2 | 18 | 366 | 404 | 18.2 | 0.0 | ||
| 2 | | 49ers | 10/18/2020 | 1-0 | +115 | vs | -135 | W 24-16 | +2.5 | +10.5 (Y) | 51.5 | -11.5 (U) | 3 | 24 | 390 | 311 | 38.5 | 100.0 | ||
| 3 | | 49ers | 11/1/2020 | 0-1 | -102 | @ | -116 | L 27-37 | +1 | -9 (N) | 54.5 | +9.5 (O) | 4 | 24 | 351 | 350 | 46.2 | 100.0 | ||
| 4 | | 49ers | 11/29/2020 | 1-0 | +196 | @ | -236 | W 23-20 | +5 | +8 (Y) | 44.5 | -1.5 (U) | 2 | 18 | 345 | 308 | 21.4 | 100.0 | ||
| 5 | | 49ers | 12/26/2020 | 1-0 | +213 | @ | -266 | W 20-12 | +6 | +14 (Y) | 49 | -17 (U) | 3 | 22 | 398 | 350 | 22.2 | |||
| 6 | | 49ers | 1/3/2021 | 1-0 | +270 | vs | -338 | L 23-26 | +7 | +4 (Y) | 45.5 | +3.5 (O) | 2 | 17 | 328 | 280 | 40.0 | 100.0 | ||
| 7 | | 49ers | 10/3/2021 | 0-1 | -137 | vs | +115 | L 21-28 | -2.5 | -9.5 (N) | 52 | -3 (U) | 3 | 23 | 457 | 234 | 14.3 | 75.0 | ||
| 8 | | 49ers | 10/10/2021 | 0-1 | +208 | @ | -257 | L 10-17 | +5.5 | -1.5 (N) | 48.5 | -21.5 (U) | 1 | 19 | 338 | 304 | 27.3 | 20.0 | ||
| 9 | | 49ers | 11/7/2021 | 0-1 | -247 | vs | +199 | L 17-31 | -5.5 | -19.5 (N) | 44.5 | +3.5 (O) | 2 | 22 | 337 | 437 | 40.0 | |||
| 10 | | 49ers | 11/15/2021 | 1-0 | +154 | vs | -184 | W 31-10 | +3.5 | +24.5 (Y) | 50 | -9 (U) | 4 | 20 | 335 | 278 | 57.1 | 50.0 | ||
| 11 | | 49ers | 12/5/2021 | 0-1 | -143 | @ | +122 | L 23-30 | -2.5 | -9.5 (N) | 44.5 | +8.5 (O) | 3 | 17 | 365 | 327 | 30.0 | 50.0 | ||
| 12 | | 49ers | 1/9/2022 | 1-0 | +151 | @ | -178 | W 27-24 | +3.5 | +6.5 (Y) | 46.5 | +4.5 (O) | 3 | 23 | 449 | 265 | 64.3 | |||
| 13 | | 49ers | 1/30/2022 | 1-0 | +155 | @ | -183 | L 17-20 | +3.5 | +0.5 (Y) | 45.5 | -8.5 (U) | 2 | 16 | 282 | 396 | 33.3 | |||
| 14 | | 49ers | 9/18/2022 | 1-0 | -394 | vs | +306 | W 27-7 | -8.5 | +11.5 (Y) | 39.5 | -5.5 (U) | 3 | 25 | 373 | 216 | 40.0 | 66.7 | ||
| 15 | | 49ers | 10/3/2022 | 1-0 | -125 | vs | +105 | W 24-9 | -2 | +13 (Y) | 42 | -9 (U) | 3 | 13 | 327 | 257 | 41.7 | 0.0 | ||
| 16 | | 49ers | 10/30/2022 | 1-0 | -107 | @ | -113 | W 31-14 | -1.5 | +15.5 (Y) | 42 | +3 (O) | 4 | 22 | 368 | 223 | 55.6 | |||
| 17 | | 49ers | 11/21/2022 | 1-0 | -442 | @ | +341 | W 38-10 | -9.5 | +18.5 (Y) | 43 | +5 (O) | 5 | 21 | 387 | 314 | 54.5 | |||
| 18 | | 49ers | 12/15/2022 | 1-0 | -181 | @ | +152 | W 21-13 | -3 | +5 (Y) | 42.5 | -8.5 (U) | 3 | 15 | 381 | 277 | 46.2 | |||
| 19 | | 49ers | 1/8/2023 | 1-0 | -1057 | vs | +693 | W 38-13 | -14.5 | +10.5 (Y) | 39.5 | +11.5 (O) | 5 | 21 | 311 | 255 | 46.2 | 0.0 | ||
| 20 | | 49ers | 1/14/2023 | 1-0 | -480 | vs | +366 | W 41-23 | -9.5 | +8.5 (Y) | 42 | +22 (O) | 4 | 24 | 505 | 332 | 54.5 | |||
| 21 | | 49ers | 9/17/2023 | 0-1 | -343 | @ | +273 | W 30-23 | -7.5 | -0.5 (N) | 45 | +8 (O) | 3 | 21 | 365 | 386 | 22.2 | |||
| 22 | | 49ers | 10/1/2023 | 1-0 | -1106 | vs | +692 | W 35-16 | -14.5 | +4.5 (Y) | 44 | +7 (O) | 5 | 30 | 395 | 362 | 60.0 | 100.0 | ||
| 23 | | 49ers | 11/23/2023 | 1-0 | -334 | @ | +260 | W 31-13 | -7 | +11 (Y) | 43 | +1 (O) | 4 | 23 | 377 | 220 | 45.5 | |||
| 24 | | 49ers | 12/10/2023 | 0-1 | -1099 | vs | +683 | W 28-16 | -14.5 | -2.5 (N) | 44.5 | -0.5 (U) | 4 | 19 | 527 | 324 | 54.5 | |||
| 25 | | 49ers | 12/17/2023 | 1-0 | -771 | @ | +529 | W 45-29 | -12.5 | +3.5 (Y) | 48 | +26 (O) | 6 | 24 | 406 | 436 | 57.1 | |||
| Average | 1.4 | 2.9 | 20.7 | 363.8 | 322.5 | 41.2 | 0.0 | |||||||||||||
| Total | 21-18 | 114 | 809 | 14,188 | 12,577 | 41.2 | 52.2 | |||||||||||||
StatMuse has team, game-level data for spread records going back to the 1979 season.
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PASS
2,167
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RUSH
1,202
McCaffrey
REC
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McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
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NFL 2025 Rankings
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NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |