The San Francisco 49ers were 109-88 against the AFC in the regular-season and playoffs before December 2, 2019.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/27/1970 | 1-0 |  SF | vs |  CLE | W 34-31 | 1.000 | 5 | 24 | 435 | 448 | ||
| 2 | | 49ers | 10/25/1970 | 1-0 | SF | vs |  DEN | W 19-14 | 1.000 | 1 | 16 | 362 | 283 | ||
| 3 | | 49ers | 11/15/1970 | 1-0 | SF | @ |  HOU | W 30-20 | 1.000 | 4 | 17 | 376 | 268 | ||
| 4 | | 49ers | 12/20/1970 | 1-0 | SF | @ |  OAK | W 38-7 | 1.000 | 5 | 16 | 296 | 358 | ||
| 5 | | 49ers | 10/31/1971 | 1-0 | SF | vs |  NE | W 27-10 | 1.000 | 3 | 13 | 247 | 246 | ||
| 6 | | 49ers | 11/28/1971 | 1-0 | SF | @ |  NYJ | W 24-21 | 1.000 | 3 | 20 | 351 | 393 | ||
| 7 | | 49ers | 12/6/1971 | 0-1 | SF | vs |  KC | L 17-26 | .000 | 2 | 18 | 331 | 427 | ||
| 8 | | 49ers | 9/17/1972 | 1-0 | SF | vs |  SD | W 34-3 | 1.000 | 4 | 18 | 295 | 258 | ||
| 9 | | 49ers | 9/24/1972 | 0-1 | SF | @ |  BUF | L 20-27 | .000 | 2 | 10 | 202 | 233 | ||
| 10 | | 49ers | 11/12/1972 | 1-0 | SF | vs |  BAL | W 24-21 | 1.000 | 3 | 19 | 310 | 297 | ||
| 11 | | 49ers | 9/16/1973 | 0-1 | SF | @ |  MIA | L 13-21 | .000 | 1 | 16 | 252 | 279 | ||
| 12 | | 49ers | 9/23/1973 | 1-0 | SF | @ | DEN | W 36-34 | 1.000 | 3 | 16 | 347 | 355 | ||
| 13 | | 49ers | 12/15/1973 | 0-1 | SF | vs |  PIT | L 14-37 | .000 | 2 | 16 | 239 | 308 | ||
| 14 | | 49ers | 9/29/1974 | 0-1 | SF | vs |  CIN | L 3-21 | .000 | 0 | 14 | 226 | 373 | ||
| 15 | | 49ers | 10/27/1974 | 0-1 | SF | vs | OAK | L 24-35 | .000 | 3 | 20 | 372 | 297 | ||
| 16 | | 49ers | 12/1/1974 | 0-1 | SF | @ | CLE | L 0-7 | .000 | 0 | 14 | 192 | 183 | ||
| 17 | | 49ers | 10/5/1975 | 1-0 | SF | @ | KC | W 20-3 | 1.000 | 2 | 15 | 215 | 212 | ||
| 18 | | 49ers | 10/26/1975 | 0-1 | SF | @ | NE | L 16-24 | .000 | 2 | 14 | 243 | 306 | ||
| 19 | | 49ers | 12/7/1975 | 0-1 | SF | vs | HOU | L 13-27 | .000 | 1 | 11 | 200 | 279 | ||
| 20 | | 49ers | 10/3/1976 | 1-0 | SF | vs | NYJ | W 17-6 | 1.000 | 2 | 16 | 247 | 261 | ||
| 21 | | 49ers | 12/5/1976 | 0-1 | SF | @ | SD | L 7-13 | .000 | 1 | 18 | 281 | 267 | ||
| 22 | | 49ers | 9/19/1977 | 0-1 | SF | @ | PIT | L 0-27 | .000 | 0 | 8 | 101 | 308 | ||
| 23 | | 49ers | 9/25/1977 | 0-1 | SF | vs | MIA | L 15-19 | .000 | 2 | 13 | 280 | 361 | ||
| 24 | | 49ers | 9/3/1978 | 0-1 | SF | @ | CLE | L 7-24 | .000 | 1 | 18 | 295 | 393 | ||
| 25 | | 49ers | 9/17/1978 | 0-1 | SF | @ | HOU | L 19-20 | .000 | 2 | 18 | 382 | 332 | ||
| Average | .553 | 2.6 | 19.7 | 344.0 | 318.7 | ||||||||||
| Total | 109-88 | .553 | 521 | 3,884 | 67,766 | 62,792 | |||||||||
More 49ers Stats
Team Rankings
PPG
19.7
23rd
OPP PPG
16.3
3rd
RUSH YDS/G
89.7
26th
PASS YDS/G
280.0
3rd
Cardinals 
Seahawks 
JAX 
ATL 
HOU 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 3 | 0 | 0 | 1.000 |
 Commanders | 2 | 1 | 0 | .667 |
| NFC North | W | L | T | PCT |
 Packers | 2 | 1 | 0 | .667 |
 Vikings | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 0 | 0 | 1.000 |
 Panthers | 1 | 2 | 0 | .333 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 0 | 0 | 1.000 |
 Rams | 2 | 1 | 0 | .667 |
Colts 
DAL 
NO 
TEN 
DET 
