The San Francisco 49ers are 43-46 against the AFC in the regular-season and playoffs on the road since December 27, 1982.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/2/1983 | 1-0 |  SF | @ |  NE | W 33-13 | 1.000 | 3 | 29 | 426 | 295 | ||
| 2 | | 49ers | 12/11/1983 | 1-0 | SF | @ |  BUF | W 23-10 | 1.000 | 2 | 19 | 310 | 303 | ||
| 3 | | 49ers | 10/21/1984 | 1-0 | SF | @ |  HOU | W 34-21 | 1.000 | 4 | 25 | 517 | 432 | ||
| 4 | | 49ers | 11/11/1984 | 1-0 | SF | @ |  CLE | W 41-7 | 1.000 | 5 | 23 | 468 | 251 | ||
| 5 | | 49ers | 9/22/1985 | 1-0 | SF | @ |  RAI | W 34-10 | 1.000 | 4 | 17 | 352 | 280 | ||
| 6 | | 49ers | 11/11/1985 | 0-1 | SF | @ |  DEN | L 16-17 | .000 | 1 | 16 | 341 | 336 | ||
| 7 | | 49ers | 9/28/1986 | 1-0 | SF | @ |  MIA | W 31-16 | 1.000 | 4 | 16 | 314 | 437 | ||
| 8 | | 49ers | 12/14/1986 | 1-0 | SF | @ | NE | W 29-24 | 1.000 | 3 | 23 | 400 | 267 | ||
| 9 | | 49ers | 9/13/1987 | 0-1 | SF | @ |  PIT | L 17-30 | .000 | 2 | 24 | 356 | 266 | ||
| 10 | | 49ers | 9/20/1987 | 1-0 | SF | @ |  CIN | W 27-26 | 1.000 | 3 | 16 | 261 | 292 | ||
| 11 | | 49ers | 9/25/1988 | 1-0 | SF | @ |  SEA | W 38-7 | 1.000 | 5 | 27 | 580 | 154 | ||
| 12 | | 49ers | 11/27/1988 | 1-0 | SF | @ |  SD | W 48-10 | 1.000 | 6 | 24 | 475 | 312 | ||
| 13 | | 49ers | 9/10/1989 | 1-0 | SF | @ |  IND | W 30-24 | 1.000 | 3 | 24 | 404 | 344 | ||
| 14 | | 49ers | 10/29/1989 | 1-0 | SF | @ |  NYJ | W 23-10 | 1.000 | 2 | 20 | 399 | 251 | ||
| 15 | | 49ers | 1/28/1990 | 1-0 | SF | @ | DEN | W 55-10 | 1.000 | 8 | 28 | 461 | 167 | ||
| 16 | | 49ers | 10/7/1990 | 1-0 | SF | @ | HOU | W 24-21 | 1.000 | 3 | 17 | 383 | 256 | ||
| 17 | | 49ers | 12/9/1990 | 1-0 | SF | @ | CIN | W 20-17 | 1.000 | 2 | 25 | 372 | 215 | ||
| 18 | | 49ers | 9/29/1991 | 0-1 | SF | @ | RAI | L 6-12 | .000 | 0 | 17 | 339 | 220 | 36.4 | 0.0 |
| 19 | | 49ers | 12/8/1991 | 1-0 | SF | @ | SEA | W 24-22 | 1.000 | 3 | 19 | 329 | 278 | 50.0 | |
| 20 | | 49ers | 9/20/1992 | 1-0 | SF | @ | NYJ | W 31-14 | 1.000 | 4 | 19 | 335 | 311 | 46.2 | 0.0 |
| 21 | | 49ers | 10/11/1992 | 1-0 | SF | @ | NE | W 24-12 | 1.000 | 3 | 24 | 411 | 227 | 37.5 | 0.0 |
| 22 | | 49ers | 9/5/1993 | 1-0 | SF | @ | PIT | W 24-13 | 1.000 | 3 | 21 | 326 | 211 | 41.7 | |
| 23 | | 49ers | 9/13/1993 | 0-1 | SF | @ | CLE | L 13-23 | .000 | 1 | 22 | 396 | 304 | 33.3 | 0.0 |
| 24 | | 49ers | 9/11/1994 | 0-1 | SF | @ |  KC | L 17-24 | .000 | 2 | 23 | 381 | 292 | 54.5 | |
| 25 | | 49ers | 12/11/1994 | 1-0 | SF | @ | SD | W 38-15 | 1.000 | 5 | 27 | 417 | 378 | 40.0 | 50.0 |
| Average | .483 | 2.5 | 19.9 | 350.7 | 330.0 | ||||||||||
| Total | 43-46 | .483 | 225 | 1,768 | 31,215 | 29,370 | |||||||||
More 49ers Stats
Team Rankings
PPG
19.7
23rd
OPP PPG
16.3
2nd
RUSH YDS/G
89.7
26th
PASS YDS/G
280.0
3rd
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HOU 
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NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 3 | 0 | 0 | 1.000 |
 Commanders | 2 | 1 | 0 | .667 |
| NFC North | W | L | T | PCT |
 Packers | 2 | 1 | 0 | .667 |
 Vikings | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 0 | 0 | 1.000 |
 Panthers | 1 | 2 | 0 | .333 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 0 | 0 | 1.000 |
| Seahawks | 3 | 1 | 0 | .750 |
DAL 
NO 
TEN 
DET 
