The San Francisco 49ers have a 10-11 record against the spread as underdogs in the regular season and playoffs since December 28, 2021.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 1/9/2022 | 1-0 | +151 | @ | -178 | W 27-24 | +3.5 | +6.5 (Y) | 46.5 | +4.5 (O) | 3 | 23 | 449 | 265 | 64.3 | |||
| 2 | | 49ers | 1/16/2022 | 1-0 | +153 | @ | -181 | W 23-17 | +3.5 | +9.5 (Y) | 51 | -11 (U) | 2 | 21 | 341 | 307 | 46.2 | |||
| 3 | | 49ers | 1/22/2022 | 1-0 | +208 | @ | -254 | W 13-10 | +5.5 | +8.5 (Y) | 47 | -24 (U) | 1 | 12 | 212 | 263 | 36.4 | 0.0 | ||
| 4 | | 49ers | 1/30/2022 | 1-0 | +155 | @ | -183 | L 17-20 | +3.5 | +0.5 (Y) | 45.5 | -8.5 (U) | 2 | 16 | 282 | 396 | 33.3 | |||
| 5 | | 49ers | 10/23/2022 | 0-1 | -103 | vs | -118 | L 23-44 | +1 | -20 (N) | 49 | +18 (O) | 2 | 25 | 444 | 529 | 57.1 | |||
| 6 | | 49ers | 10/30/2022 | 1-0 | -107 | @ | -113 | W 31-14 | -1.5 | +15.5 (Y) | 42 | +3 (O) | 4 | 22 | 368 | 223 | 55.6 | |||
| 7 | | 49ers | 1/29/2023 | 0-1 | +131 | @ | -155 | L 7-31 | +3 | -21 (N) | 44.5 | -6.5 (U) | 1 | 11 | 164 | 269 | 25.0 | 0.0 | ||
| 8 | | 49ers | 11/24/2024 | 0-1 | +237 | @ | -292 | L 10-38 | +6 | -22 (N) | 45 | +3 (O) | 1 | 11 | 241 | 325 | 30.0 | 0.0 | ||
| 9 | | 49ers | 12/1/2024 | 0-1 | +265 | @ | -330 | L 10-35 | +6.5 | -18.5 (N) | 45.5 | -0.5 (U) | 1 | 15 | 239 | 372 | 30.0 | 100.0 | ||
| 10 | | 49ers | 12/30/2024 | 0-1 | +183 | vs | -223 | L 34-40 | +3.5 | -2.5 (N) | 50.5 | +23.5 (O) | 5 | 29 | 475 | 439 | 62.5 | 100.0 | ||
| 11 | | 49ers | 1/5/2025 | 0-1 | +188 | @ | -229 | L 24-47 | +4.5 | -18.5 (N) | 43 | +28 (O) | 3 | 26 | 436 | 393 | 38.5 | 50.0 | ||
| 12 | | 49ers | 10/2/2025 | 1-0 | +344 | @ | -444 | W 26-23 | +8.5 | +11.5 (Y) | 43.5 | +5.5 (O) | 2 | 27 | 407 | 456 | 38.9 | 100.0 | ||
| 13 | | 49ers | 10/12/2025 | 0-1 | +158 | @ | -189 | L 19-30 | +3.5 | -7.5 (N) | 47 | +2 (O) | 1 | 17 | 363 | 352 | 43.8 | 0.0 | ||
| 14 | | 49ers | 10/19/2025 | 1-0 | -106 | vs | -112 | W 20-10 | -1.5 | +8.5 (Y) | 46.5 | -16.5 (U) | 2 | 23 | 324 | 292 | 60.0 | |||
| 15 | | 49ers | 10/26/2025 | 0-1 | +135 | @ | -159 | L 15-26 | +3 | -8 (N) | 42 | -1 (U) | 2 | 12 | 223 | 475 | 33.3 | 0.0 | ||
| 16 | | 49ers | 11/9/2025 | 0-1 | +210 | vs | -254 | L 26-42 | +5.5 | -10.5 (N) | 49.5 | +18.5 (O) | 4 | 24 | 393 | 401 | 37.5 | 33.3 | ||
| 17 | | 49ers | 1/3/2026 | 0-1 | +131 | vs | -156 | L 3-13 | +2.5 | -7.5 (N) | 48.5 | -32.5 (U) | 0 | 9 | 173 | 361 | 22.2 | 0.0 | ||
| 18 | | 49ers | 1/11/2026 | 1-0 | +208 | @ | -262 | W 23-19 | +5.5 | +9.5 (Y) | 44.5 | -2.5 (U) | 3 | 20 | 361 | 307 | 54.5 | |||
| 19 | | 49ers | 1/17/2026 | 0-1 | +245 | @ | -304 | L 6-41 | +7 | -28 (N) | 44.5 | +2.5 (O) | 0 | 15 | 236 | 281 | 50.0 | 0.0 | ||
| 20 | | 49ers | 9/10/2026 | 1-0 | +172 | @ | -207 | W 27-7 | +3.5 | +23.5 (Y) | 47.5 | -13.5 (U) | 3 | 23 | 379 | 290 | 58.3 | |||
| 21 | | 49ers | 10/11/2026 | 1-0 | +135 | @ | -164 | W 32-29 | +3 | +6 (Y) | 46.5 | +14.5 (O) | 4 | 14 | 269 | 251 | 33.3 | |||
| Average | 2.3 | 2.2 | 18.8 | 322.8 | 345.1 | 44.4 | 0.0 | |||||||||||||
| Total | 10-11 | 46 | 395 | 6,779 | 7,247 | 44.4 | 30.4 |
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More 49ers Stats
Team Leaders 
PASS
1,196
Purdy
RUSH
286
McCaffrey
REC
326
Evans
Team Rankings
PPG
30.8
3rd
OPP PPG
18.6
3rd
RUSH YDS/G
128.6
8th
PASS YDS/G
239.2
16th
WAS
LV
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 3 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 |
Giants
Bears
Panthers
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
4 | 2 | 0 | .667 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
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