The San Francisco 49ers have a 5-8 record against the spread against the NFC West at home since July 31, 2022.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/18/2022 | 1-0 | -394 | vs | +306 | W 27-7 | -8.5 | +11.5 (Y) | 39.5 | -5.5 (U) | 3 | 25 | 373 | 216 | 40.0 | 66.7 | ||
| 2 | | 49ers | 10/3/2022 | 1-0 | -125 | vs | +105 | W 24-9 | -2 | +13 (Y) | 42 | -9 (U) | 3 | 13 | 327 | 257 | 41.7 | 0.0 | ||
| 3 | | 49ers | 1/8/2023 | 1-0 | -1057 | vs | +693 | W 38-13 | -14.5 | +10.5 (Y) | 39.5 | +11.5 (O) | 5 | 21 | 311 | 255 | 46.2 | 0.0 | ||
| 4 | | 49ers | 1/14/2023 | 1-0 | -480 | vs | +366 | W 41-23 | -9.5 | +8.5 (Y) | 42 | +22 (O) | 4 | 24 | 505 | 332 | 54.5 | |||
| 5 | | 49ers | 10/1/2023 | 1-0 | -1106 | vs | +692 | W 35-16 | -14.5 | +4.5 (Y) | 44 | +7 (O) | 5 | 30 | 395 | 362 | 60.0 | 100.0 | ||
| 6 | | 49ers | 12/10/2023 | 0-1 | -1099 | vs | +683 | W 28-16 | -14.5 | -2.5 (N) | 44.5 | -0.5 (U) | 4 | 19 | 527 | 324 | 54.5 | |||
| 7 | | 49ers | 1/7/2024 | 0-1 | -246 | vs | +199 | L 20-21 | -5.5 | -6.5 (N) | 40 | +1 (O) | 3 | 20 | 300 | 258 | 50.0 | 100.0 | ||
| 8 | | 49ers | 10/6/2024 | 0-1 | -350 | vs | +278 | L 23-24 | -7.5 | -8.5 (N) | 48.5 | -1.5 (U) | 2 | 22 | 384 | 358 | 54.5 | 0.0 | ||
| 9 | | 49ers | 11/17/2024 | 0-1 | -262 | vs | +214 | L 17-20 | -6 | -9 (N) | 48.5 | -11.5 (U) | 2 | 21 | 277 | 289 | 63.6 | |||
| 10 | | 49ers | 12/12/2024 | 0-1 | -156 | vs | +131 | L 6-12 | -3 | -9 (N) | 48.5 | -30.5 (U) | 0 | 11 | 191 | 302 | 25.0 | |||
| 11 | | 49ers | 9/21/2025 | 0-1 | -123 | vs | +103 | W 16-15 | -1.5 | -0.5 (N) | 44.5 | -13.5 (U) | 1 | 19 | 355 | 260 | 20.0 | 50.0 | ||
| 12 | | 49ers | 11/9/2025 | 0-1 | +210 | vs | -254 | L 26-42 | +5.5 | -10.5 (N) | 49.5 | +18.5 (O) | 4 | 24 | 393 | 401 | 37.5 | 33.3 | ||
| 13 | | 49ers | 1/3/2026 | 0-1 | +131 | vs | -156 | L 3-13 | +2.5 | -7.5 (N) | 48.5 | -32.5 (U) | 0 | 9 | 173 | 361 | 22.2 | 0.0 | ||
| Average | 3.0 | 2.8 | 19.8 | 347.0 | 305.8 | 43.5 | 0.0 | |||||||||||||
| Total | 5-8 | 36 | 258 | 4,511 | 3,975 | 43.5 | 40.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |