The San Francisco 49ers are 13-9 against the spread as favorites against the NFC at home since November 1, 2022.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/27/2022 | 1-0 |  SF | -426 | vs |  NO | +325 | W 13-0 | -8.5 | +4.5 (Y) | 43.5 | -30.5 (U) | 1 | 21 | 317 | 260 | 38.5 | 50.0 |
| 2 | | 49ers | 12/11/2022 | 1-0 | SF | -182 | vs |  TB | +152 | W 35-7 | -3.5 | +24.5 (Y) | 38.5 | +3.5 (O) | 5 | 24 | 404 | 322 | 44.4 | 50.0 |
| 3 | | 49ers | 12/24/2022 | 1-0 | SF | -299 | vs |  WAS | +240 | W 37-20 | -6.5 | +10.5 (Y) | 37 | +20 (O) | 4 | 14 | 371 | 349 | 36.4 | 50.0 |
| 4 | | 49ers | 1/8/2023 | 1-0 | SF | -1057 | vs |  ARI | +693 | W 38-13 | -14.5 | +10.5 (Y) | 39.5 | +11.5 (O) | 5 | 21 | 311 | 255 | 46.2 | 0.0 |
| 5 | | 49ers | 1/14/2023 | 1-0 | SF | -480 | vs |  SEA | +366 | W 41-23 | -9.5 | +8.5 (Y) | 42 | +22 (O) | 4 | 24 | 505 | 332 | 54.5 | |
| 6 | | 49ers | 1/22/2023 | 1-0 | SF | -194 | vs |  DAL | +162 | W 19-12 | -3.5 | +3.5 (Y) | 46.5 | -15.5 (U) | 1 | 21 | 312 | 282 | 50.0 | |
| 7 | | 49ers | 9/21/2023 | 1-0 | SF | -573 | vs |  NYG | +426 | W 30-12 | -10.5 | +7.5 (Y) | 43.5 | -1.5 (U) | 3 | 26 | 441 | 150 | 56.3 | |
| 8 | | 49ers | 10/1/2023 | 1-0 | SF | -1106 | vs | ARI | +692 | W 35-16 | -14.5 | +4.5 (Y) | 44 | +7 (O) | 5 | 30 | 395 | 362 | 60.0 | 100.0 |
| 9 | | 49ers | 10/8/2023 | 1-0 | SF | -182 | vs | DAL | +154 | W 42-10 | -3.5 | +28.5 (Y) | 45.5 | +6.5 (O) | 6 | 25 | 421 | 197 | 54.5 | 0.0 |
| 10 | | 49ers | 11/19/2023 | 0-1 | SF | -831 | vs | TB | +567 | W 27-14 | -13.5 | -0.5 (N) | 41.5 | -0.5 (U) | 3 | 22 | 420 | 287 | 40.0 | 0.0 |
| 11 | | 49ers | 12/10/2023 | 0-1 | SF | -1099 | vs | SEA | +683 | W 28-16 | -14.5 | -2.5 (N) | 44.5 | -0.5 (U) | 4 | 19 | 527 | 324 | 54.5 | |
| 12 | | 49ers | 1/7/2024 | 0-1 | SF | -246 | vs |  LAR | +199 | L 20-21 | -5.5 | -6.5 (N) | 40 | +1 (O) | 3 | 20 | 300 | 258 | 50.0 | 100.0 |
| 13 | | 49ers | 1/20/2024 | 0-1 | SF | -502 | vs |  GB | +377 | W 24-21 | -10.5 | -7.5 (N) | 50.5 | -5.5 (U) | 3 | 19 | 356 | 330 | 62.5 | |
| 14 | | 49ers | 1/28/2024 | 0-1 | SF | -357 | vs |  DET | +282 | W 34-31 | -7.5 | -4.5 (N) | 53.5 | +11.5 (O) | 4 | 23 | 413 | 442 | 50.0 | 0.0 |
| 15 | | 49ers | 10/6/2024 | 0-1 | SF | -350 | vs | ARI | +278 | L 23-24 | -7.5 | -8.5 (N) | 48.5 | -1.5 (U) | 2 | 22 | 384 | 358 | 54.5 | 0.0 |
| 16 | | 49ers | 10/27/2024 | 1-0 | SF | -249 | vs | DAL | +203 | W 30-24 | -5.5 | +0.5 (Y) | 47.5 | +6.5 (O) | 3 | 19 | 469 | 292 | 50.0 | 0.0 |
| 17 | | 49ers | 11/17/2024 | 0-1 | SF | -262 | vs | SEA | +214 | L 17-20 | -6 | -9 (N) | 48.5 | -11.5 (U) | 2 | 21 | 277 | 289 | 63.6 | |
| 18 | | 49ers | 12/8/2024 | 1-0 | SF | -168 | vs |  CHI | +140 | W 38-13 | -3 | +22 (Y) | 44 | +7 (O) | 5 | 22 | 452 | 162 | 50.0 | 100.0 |
| 19 | | 49ers | 12/12/2024 | 0-1 | SF | -156 | vs | LAR | +131 | L 6-12 | -3 | -9 (N) | 48.5 | -30.5 (U) | 0 | 11 | 191 | 302 | 25.0 | |
| 20 | | 49ers | 9/21/2025 | 0-1 | SF | -123 | vs | ARI | +103 | W 16-15 | -1.5 | -0.5 (N) | 44.5 | -13.5 (U) | 1 | 19 | 355 | 260 | 20.0 | 50.0 |
| 21 | | 49ers | 10/19/2025 | 1-0 | SF | -106 | vs |  ATL | -112 | W 20-10 | -1.5 | +8.5 (Y) | 46.5 | -16.5 (U) | 2 | 23 | 324 | 292 | 60.0 | |
| 22 | | 49ers | 11/24/2025 | 1-0 | SF | -386 | vs |  CAR | +307 | W 20-9 | -7.5 | +3.5 (Y) | 49.5 | -20.5 (U) | 2 | 23 | 340 | 230 | 53.8 | 100.0 |
| Average | 2.7 | 3.1 | 21.3 | 376.6 | 288.0 | 49.2 | 3.6 | |||||||||||||
| Total | 13-9 | 68 | 469 | 8,285 | 6,335 | 49.2 | 50.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
23.4
15th
OPP PPG
21.8
11th
RUSH YDS/G
99.2
26th
PASS YDS/G
260.8
4th
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