The San Francisco 49ers have a record of 29-23 against the AFC in the regular-season and playoffs at home since September 11, 2001.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 12/2/2001 | 1-0 |  SF | vs |  BUF | W 35-0 | 1.000 | 5 | 26 | 409 | 191 | 66.7 | 0.0 |
| 2 | | 49ers | 12/16/2001 | 1-0 | SF | vs |  MIA | W 21-0 | 1.000 | 3 | 21 | 285 | 174 | 50.0 | 50.0 |
| 3 | | 49ers | 9/15/2002 | 0-1 | SF | vs |  DEN | L 14-24 | .000 | 2 | 18 | 261 | 299 | 61.5 | |
| 4 | | 49ers | 11/10/2002 | 1-0 | SF | vs |  KC | W 17-13 | 1.000 | 2 | 22 | 323 | 256 | 61.1 | 100.0 |
| 5 | | 49ers | 9/21/2003 | 0-1 | SF | vs |  CLE | L 12-13 | .000 | 0 | 15 | 265 | 251 | 33.3 | 0.0 |
| 6 | | 49ers | 11/17/2003 | 1-0 | SF | vs |  PIT | W 30-14 | 1.000 | 3 | 17 | 423 | 349 | 33.3 | 0.0 |
| 7 | | 49ers | 11/28/2004 | 0-1 | SF | vs | MIA | L 17-24 | .000 | 2 | 16 | 224 | 200 | 31.3 | |
| 8 | | 49ers | 12/26/2004 | 0-1 | SF | vs | BUF | L 7-41 | .000 | 1 | 12 | 189 | 441 | 30.0 | 100.0 |
| 9 | | 49ers | 10/9/2005 | 0-1 | SF | vs |  IND | L 3-28 | .000 | 0 | 12 | 177 | 365 | 21.4 | 100.0 |
| 10 | | 49ers | 1/1/2006 | 1-0 | SF | vs |  HOU | W 20-17 | 1.000 | 2 | 19 | 324 | 284 | 36.8 | |
| 11 | | 49ers | 10/8/2006 | 1-0 | SF | vs |  OAK | W 34-20 | 1.000 | 4 | 18 | 330 | 370 | 45.5 | 0.0 |
| 12 | | 49ers | 10/15/2006 | 0-1 | SF | vs |  SD | L 19-48 | .000 | 2 | 15 | 274 | 421 | 36.4 | 0.0 |
| 13 | | 49ers | 10/7/2007 | 0-1 | SF | vs |  BAL | L 7-9 | .000 | 1 | 6 | 163 | 315 | 25.0 | |
| 14 | | 49ers | 12/15/2007 | 1-0 | SF | vs |  CIN | W 20-13 | 1.000 | 2 | 22 | 337 | 313 | 60.0 | 0.0 |
| 15 | | 49ers | 10/5/2008 | 0-1 | SF | vs |  NE | L 21-30 | .000 | 3 | 12 | 199 | 377 | 11.1 | 0.0 |
| 16 | | 49ers | 12/7/2008 | 1-0 | SF | vs |  NYJ | W 24-14 | 1.000 | 3 | 25 | 375 | 182 | 53.3 | 100.0 |
| 17 | | 49ers | 11/8/2009 | 0-1 | SF | vs |  TEN | L 27-34 | .000 | 3 | 25 | 358 | 315 | 30.8 | 100.0 |
| 18 | | 49ers | 11/29/2009 | 1-0 | SF | vs |  JAX | W 20-3 | 1.000 | 2 | 15 | 284 | 357 | 50.0 | 100.0 |
| 19 | | 49ers | 10/17/2010 | 1-0 | SF | vs | OAK | W 17-9 | 1.000 | 2 | 17 | 349 | 179 | 41.2 | |
| 20 | | 49ers | 10/31/2010 | 1-0 | SF | vs | DEN | W 24-16 | 1.000 | 3 | 16 | 339 | 398 | 38.5 | |
| 21 | | 49ers | 10/30/2011 | 1-0 | SF | vs | CLE | W 20-10 | 1.000 | 2 | 19 | 348 | 290 | 40.0 | 0.0 |
| 22 | | 49ers | 12/19/2011 | 1-0 | SF | vs | PIT | W 20-3 | 1.000 | 2 | 17 | 287 | 389 | 30.8 | |
| 23 | | 49ers | 10/7/2012 | 1-0 | SF | vs | BUF | W 45-3 | 1.000 | 6 | 29 | 621 | 204 | 63.6 | 100.0 |
| 24 | | 49ers | 12/9/2012 | 1-0 | SF | vs | MIA | W 27-13 | 1.000 | 3 | 20 | 321 | 227 | 20.0 | |
| 25 | | 49ers | 2/3/2013 | 0-1 | SF | vs | BAL | L 31-34 | .000 | 3 | 23 | 468 | 367 | 22.2 | 0.0 |
| Average | .558 | 2.5 | 19.5 | 347.4 | 316.8 | 40.8 | 1.3 | ||||||||
| Total | 29-23 | .558 | 129 | 1,014 | 18,065 | 16,475 | 40.8 | 41.3 | |||||||
More 49ers Stats
Team Rankings
PPG
21.2
23rd
OPP PPG
19.6
7th
RUSH YDS/G
85.2
29th
PASS YDS/G
298.2
1st
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ATL 
NYG 
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NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
 Lions | 4 | 1 | 0 | .800 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 4 | 1 | 0 | .800 |
 Panthers | 3 | 3 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 1 | 0 | .800 |
 Seahawks | 4 | 2 | 0 | .667 |
DAL 
NYJ 
CHI 
